Annotation Details for CACNA1C
Basic Information Top
Gene Symbol: | CACNA1C ( CACH2,CACN2,CACNL1A1,CCHL1A1,CaV1.2,MGC120730,TS ) |
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Gene Full Name: | calcium channel, voltage-dependent, L type, alpha 1C subunit |
Band: | 12p13.33 |
Quick Links | Entrez ID:775; OMIM: 114205; Uniprot ID:CAC1C_HUMAN; ENSEMBL ID: ENSG00000151067; HGNC ID: 1390 |
Relate to Another Database: | SFARIGene; denovo-db |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0005737 | IDA | - | cytoplasm | 11206130 |
GO:0005886 | IDA | - | plasma membrane | 11206130 |
GO:0005886 | TAS | - | plasma membrane | - |
GO:0005891 | IDA | - | voltage-gated calcium channel complex | 12130699 |
GO:0014069 | IDA | - | postsynaptic density | 14140941 |
GO:0016021 | IDA | - | integral component of membrane | 8392192 |
GO:0030018 | ISS | - | Z disc | - |
GO:1990454 | IDA | - | L-type voltage-gated calcium channel complex | 15454078 |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0005245 | IDA | - | voltage-gated calcium channel activity | 8392192 |
GO:0005245 | IMP | - | voltage-gated calcium channel activity | 24728418 |
GO:0005245 | TAS | - | voltage-gated calcium channel activity | - |
GO:0005515 | IPI | - | protein binding | 11438518 |
GO:0008331 | IDA | - | high voltage-gated calcium channel activity | 15454078 |
GO:0008331 | TAS | contributes_to | high voltage-gated calcium channel activity | 11576544 |
GO:0046872 | IEA | - | metal ion binding | - |
GO:0051393 | IPI | - | alpha-actinin binding | 17110593 |
GO:0086007 | IMP | - | voltage-gated calcium channel activity involved in cardiac muscle cell action potential | 15454078 |
GO:0086007 | IMP | contributes_to | voltage-gated calcium channel activity involved in cardiac muscle cell action potential | 17224476 |
GO:0086056 | IMP | - | voltage-gated calcium channel activity involved in AV node cell action potential | 26253506 |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0002520 | IMP | - | immune system development | 15454078 |
GO:0007204 | IDA | - | positive regulation of cytosolic calcium ion concentration | 12130699 |
GO:0007507 | IMP | - | heart development | 15454078 |
GO:0010881 | TAS | - | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 11576544 |
GO:0035115 | IMP | - | embryonic forelimb morphogenesis | 15454078 |
GO:0035585 | TAS | - | calcium-mediated signaling using extracellular calcium source | 11576544 |
GO:0043010 | IMP | - | camera-type eye development | 15454078 |
GO:0050796 | TAS | - | regulation of insulin secretion | - |
GO:0060402 | TAS | - | calcium ion transport into cytosol | 19095005 |
GO:0061337 | IMP | - | cardiac conduction | 24728418 |
GO:0061337 | TAS | - | cardiac conduction | - |
GO:0061577 | IDA | - | calcium ion transmembrane transport via high voltage-gated calcium channel | 15454078 |
GO:0070588 | IDA | - | calcium ion transmembrane transport | 15454078 |
GO:0070588 | IMP | - | calcium ion transmembrane transport | 24728418 |
GO:0086002 | IMP | - | cardiac muscle cell action potential involved in contraction | 15454078 |
GO:0086012 | IMP | - | membrane depolarization during cardiac muscle cell action potential | 15454078 |
GO:0086045 | IMP | - | membrane depolarization during AV node cell action potential | 26253506 |
GO:0086064 | TAS | - | cell communication by electrical coupling involved in cardiac conduction | 11576544 |
GO:0086091 | IMP | - | regulation of heart rate by cardiac conduction | 15454078 |
GO:0098911 | IMP | - | regulation of ventricular cardiac muscle cell action potential | 15454078 |
GO:0098912 | IMP | - | membrane depolarization during atrial cardiac muscle cell action potential | 17224476 |
Gene Symbol | Interactant | Interaction ID | References | Description |
---|---|---|---|---|
SRI | CACNA1C | 112595 | 9668070 | Reconstituted Complex |
SRI | CACNA1C | 107229 | 9668070 | Reconstituted Complex |
PCBD1 | CACNA1C | 107229 | 11461190 | Two-hybrid |
PCBD1 | CACNA1C | 111125 | 11461190 | Two-hybrid |
RYR2 | CACNA1C | 107229 | 11576544 | Reconstituted Complex |
RYR2 | CACNA1C | 112174 | 11576544 | Reconstituted Complex |
CABP1 | CACNA1C | 107229 | 15140941 | Affinity Capture-Western; Reconstituted Complex |
CABP1 | CACNA1C | 114863 | 15140941 | Affinity Capture-Western; Reconstituted Complex |
CACNB3 | CACNA1C | 107229 | 15170217 | Co-crystal Structure |
CACNB3 | CACNA1C | 107238 | 15170217 | Co-crystal Structure |
HDAC4 | CACNA1C | 107229 | 21464227 | Reconstituted Complex |
HDAC4 | CACNA1C | 115106 | 21464227 | Reconstituted Complex |
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No data |
No data |
No data |
Gene Symbol | Poly Names | Gene overview in SZGene |
---|---|---|
CACNA1C | rs1006737 | Gene overview in SZGene |
- MGI ID: MGI:103013
- Data Attributes: MGI curated and HomoloGene calculated
- ZFIN ID: ZDB-GENE-020129-1