AutismKB 2.0

Annotation Details for CACNA1C


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Basic Information Top
Gene Symbol:CACNA1C ( CACH2,CACN2,CACNL1A1,CCHL1A1,CaV1.2,MGC120730,TS )
Gene Full Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Band: 12p13.33
Quick LinksEntrez ID:775; OMIM: 114205; Uniprot ID:CAC1C_HUMAN; ENSEMBL ID: ENSG00000151067; HGNC ID: 1390
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm11206130
GO:0005886IDA-plasma membrane11206130
GO:0005886TAS-plasma membrane-
GO:0005891IDA-voltage-gated calcium channel complex12130699
GO:0014069IDA-postsynaptic density14140941
GO:0016021IDA-integral component of membrane8392192
GO:0030018ISS-Z disc-
GO:1990454IDA-L-type voltage-gated calcium channel complex15454078
GO ID Evidence Qualifier GO_term References
GO:0005245IDA-voltage-gated calcium channel activity8392192
GO:0005245IMP-voltage-gated calcium channel activity24728418
GO:0005245TAS-voltage-gated calcium channel activity-
GO:0005515IPI-protein binding11438518
GO:0008331IDA-high voltage-gated calcium channel activity15454078
GO:0008331TAScontributes_tohigh voltage-gated calcium channel activity11576544
GO:0046872IEA-metal ion binding-
GO:0051393IPI-alpha-actinin binding17110593
GO:0086007IMP-voltage-gated calcium channel activity involved in cardiac muscle cell action potential15454078
GO:0086007IMPcontributes_tovoltage-gated calcium channel activity involved in cardiac muscle cell action potential17224476
GO:0086056IMP-voltage-gated calcium channel activity involved in AV node cell action potential26253506
GO ID Evidence Qualifier GO_term References
GO:0002520IMP-immune system development15454078
GO:0007204IDA-positive regulation of cytosolic calcium ion concentration12130699
GO:0007507IMP-heart development15454078
GO:0010881TAS-regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion11576544
GO:0035115IMP-embryonic forelimb morphogenesis15454078
GO:0035585TAS-calcium-mediated signaling using extracellular calcium source11576544
GO:0043010IMP-camera-type eye development15454078
GO:0050796TAS-regulation of insulin secretion-
GO:0060402TAS-calcium ion transport into cytosol19095005
GO:0061337IMP-cardiac conduction24728418
GO:0061337TAS-cardiac conduction-
GO:0061577IDA-calcium ion transmembrane transport via high voltage-gated calcium channel15454078
GO:0070588IDA-calcium ion transmembrane transport15454078
GO:0070588IMP-calcium ion transmembrane transport24728418
GO:0086002IMP-cardiac muscle cell action potential involved in contraction15454078
GO:0086012IMP-membrane depolarization during cardiac muscle cell action potential15454078
GO:0086045IMP-membrane depolarization during AV node cell action potential26253506
GO:0086064TAS-cell communication by electrical coupling involved in cardiac conduction11576544
GO:0086091IMP-regulation of heart rate by cardiac conduction15454078
GO:0098911IMP-regulation of ventricular cardiac muscle cell action potential15454078
GO:0098912IMP-membrane depolarization during atrial cardiac muscle cell action potential17224476
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SRICACNA1C1125959668070 Reconstituted Complex
SRICACNA1C1072299668070 Reconstituted Complex
PCBD1CACNA1C10722911461190 Two-hybrid
PCBD1CACNA1C11112511461190 Two-hybrid
RYR2CACNA1C10722911576544 Reconstituted Complex
RYR2CACNA1C11217411576544 Reconstituted Complex
CABP1CACNA1C10722915140941 Affinity Capture-Western; Reconstituted Complex
CABP1CACNA1C11486315140941 Affinity Capture-Western; Reconstituted Complex
CACNB3CACNA1C10722915170217 Co-crystal Structure
CACNB3CACNA1C10723815170217 Co-crystal Structure
HDAC4CACNA1C10722921464227 Reconstituted Complex
HDAC4CACNA1C11510621464227 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
CACNA1Crs1006737 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:103013
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-020129-1'