Gene Symbol:	CACNA1C ( CACH2,CACN2,CACNL1A1,CCHL1A1,CaV1.2,MGC120730,TS )
Gene Full Name:	calcium channel, voltage-dependent, L type, alpha 1C subunit
Band:	12p13.33
Quick Links	Entrez ID:775; OMIM: 114205; Uniprot ID:CAC1C_HUMAN; ENSEMBL ID: ENSG00000151067; HGNC ID: 1390
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005737	IDA	-	cytoplasm	11206130
GO:0005886	IDA	-	plasma membrane	11206130
GO:0005886	TAS	-	plasma membrane	-
GO:0005891	IDA	-	voltage-gated calcium channel complex	12130699
GO:0014069	IDA	-	postsynaptic density	14140941
GO:0016021	IDA	-	integral component of membrane	8392192
GO:0030018	ISS	-	Z disc	-
GO:1990454	IDA	-	L-type voltage-gated calcium channel complex	15454078

GO ID	Evidence	Qualifier	GO_term	References
GO:0005245	IDA	-	voltage-gated calcium channel activity	8392192
GO:0005245	IMP	-	voltage-gated calcium channel activity	24728418
GO:0005245	TAS	-	voltage-gated calcium channel activity	-
GO:0005515	IPI	-	protein binding	11438518
GO:0008331	IDA	-	high voltage-gated calcium channel activity	15454078
GO:0008331	TAS	contributes_to	high voltage-gated calcium channel activity	11576544
GO:0046872	IEA	-	metal ion binding	-
GO:0051393	IPI	-	alpha-actinin binding	17110593
GO:0086007	IMP	-	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	15454078
GO:0086007	IMP	contributes_to	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	17224476
GO:0086056	IMP	-	voltage-gated calcium channel activity involved in AV node cell action potential	26253506

GO ID	Evidence	Qualifier	GO_term	References
GO:0002520	IMP	-	immune system development	15454078
GO:0007204	IDA	-	positive regulation of cytosolic calcium ion concentration	12130699
GO:0007507	IMP	-	heart development	15454078
GO:0010881	TAS	-	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	11576544
GO:0035115	IMP	-	embryonic forelimb morphogenesis	15454078
GO:0035585	TAS	-	calcium-mediated signaling using extracellular calcium source	11576544
GO:0043010	IMP	-	camera-type eye development	15454078
GO:0050796	TAS	-	regulation of insulin secretion	-
GO:0060402	TAS	-	calcium ion transport into cytosol	19095005
GO:0061337	IMP	-	cardiac conduction	24728418
GO:0061337	TAS	-	cardiac conduction	-
GO:0061577	IDA	-	calcium ion transmembrane transport via high voltage-gated calcium channel	15454078
GO:0070588	IDA	-	calcium ion transmembrane transport	15454078
GO:0070588	IMP	-	calcium ion transmembrane transport	24728418
GO:0086002	IMP	-	cardiac muscle cell action potential involved in contraction	15454078
GO:0086012	IMP	-	membrane depolarization during cardiac muscle cell action potential	15454078
GO:0086045	IMP	-	membrane depolarization during AV node cell action potential	26253506
GO:0086064	TAS	-	cell communication by electrical coupling involved in cardiac conduction	11576544
GO:0086091	IMP	-	regulation of heart rate by cardiac conduction	15454078
GO:0098911	IMP	-	regulation of ventricular cardiac muscle cell action potential	15454078
GO:0098912	IMP	-	membrane depolarization during atrial cardiac muscle cell action potential	17224476

Gene Symbol	Interactant	Interaction ID	References	Description
SRI	CACNA1C	112595	9668070	Reconstituted Complex
SRI	CACNA1C	107229	9668070	Reconstituted Complex
PCBD1	CACNA1C	107229	11461190	Two-hybrid
PCBD1	CACNA1C	111125	11461190	Two-hybrid
RYR2	CACNA1C	107229	11576544	Reconstituted Complex
RYR2	CACNA1C	112174	11576544	Reconstituted Complex
CABP1	CACNA1C	107229	15140941	Affinity Capture-Western; Reconstituted Complex
CABP1	CACNA1C	114863	15140941	Affinity Capture-Western; Reconstituted Complex
CACNB3	CACNA1C	107229	15170217	Co-crystal Structure
CACNB3	CACNA1C	107238	15170217	Co-crystal Structure
HDAC4	CACNA1C	107229	21464227	Reconstituted Complex
HDAC4	CACNA1C	115106	21464227	Reconstituted Complex

AutismKB 2.0

Annotation Details for CACNA1C