AutismKB 2.0

Annotation Details for MAP3K12


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Basic Information Top
Gene Symbol:MAP3K12 ( DLK,MEKK12,MUK,ZPK,ZPKP1 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 12
Band: 12q13.13
Quick LinksEntrez ID:7786; OMIM: 600447; Uniprot ID:M3K12_HUMAN; ENSEMBL ID: ENSG00000139625; HGNC ID: 6851
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737TAS-cytoplasm8663324
GO:0005829ISS-cytosol-
GO:0005886ISS-plasma membrane-
GO:0016020ISS-membrane9353328
GO:0030424IEA-axon-
GO:0030426IEA-growth cone-
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity8637721
GO:0004674IBA-protein serine/threonine kinase activity-
GO:0004674ISS-protein serine/threonine kinase activity9353328
GO:0004709IEA-MAP kinase kinase kinase activity-
GO:0004871IBA-signal transducer activity-
GO:0005515IPI-protein binding16169070
GO:0005524IEA-ATP binding-
GO:0019901IPI-protein kinase binding14697235
GO:0042803ISS-protein homodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0000165IBA-MAPK cascade-
GO:0000186IEA-activation of MAPKK activity-
GO:0006468IDA-protein phosphorylation14697235
GO:0006468ISS-protein phosphorylation-
GO:0007254ISS-JNK cascade9353328
GO:0016572ISS-histone phosphorylation-
GO:0018105ISS-peptidyl-serine phosphorylation-
GO:0018107ISS-peptidyl-threonine phosphorylation-
GO:0035556TAS-intracellular signal transduction7983011
GO:0046777ISS-protein autophosphorylation9353328
GO:2000672IEA-negative regulation of motor neuron apoptotic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP3K12EGFR10827620029029 Affinity Capture-Western; PCA
MAP3K12EGFR11356620029029 Affinity Capture-Western; PCA
MAP3K12FTL11356616169070 Two-hybrid
MAP3K12FTL10878916169070 Two-hybrid
MAP3K12MAP2K711356610187804 Affinity Capture-Western; Biochemical Activity
MAP3K12MAP2K711159510187804 Affinity Capture-Western; Biochemical Activity
MAP3K12RGS111356616169070 Two-hybrid
MAP3K12RGS111192816169070 Two-hybrid
MAPK8IP2MAP3K1211356610490659 Affinity Capture-Western; Reconstituted Complex
MAPK8IP2MAP3K1211708610490659 Affinity Capture-Western; Reconstituted Complex
MAPK8IP1MAP3K1211356610490659 Affinity Capture-Western; Reconstituted Complex
MAPK8IP1MAP3K1211486410490659 Affinity Capture-Western; Reconstituted Complex
MBIPMAP3K1211356610801814 Affinity Capture-Western; Two-hybrid
MBIPMAP3K1211961210801814 Affinity Capture-Western; Two-hybrid
TSC22D1MAP3K1211356616169070 Two-hybrid
TSC22D1MAP3K1211437416169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346881
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2436'