AutismKB 2.0

Annotation Details for LRP8


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Basic Information Top
Gene Symbol:LRP8 ( APOER2,HSZ75190,MCI1 )
Gene Full Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Band: 1p32.3
Quick LinksEntrez ID:7804; OMIM: 602600; Uniprot ID:LRP8_HUMAN; ENSEMBL ID: ENSG00000157193; HGNC ID: 6700
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IEA-extracellular region-
GO:0005875IEA-microtubule associated complex-
GO:0005886TAS-plasma membrane-
GO:0005901IDA-caveola11369809
GO:0014069IEA-postsynaptic density-
GO:0016020IDA-membrane19946888
GO:0016021IC-integral component of membrane11152697
GO:0030424IEA-axon-
GO:0030425IEA-dendrite-
GO:0043025IEA-neuronal cell body-
GO:0043235IDA-receptor complex23382219
GO ID Evidence Qualifier GO_term References
GO:0004888TAS-transmembrane signaling receptor activity8626535
GO:0005041TAS-low-density lipoprotein receptor activity-
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding12950167
GO:0008035IEA-high-density lipoprotein particle binding-
GO:0019894IEA-kinesin binding-
GO:0030229IDA-very-low-density lipoprotein particle receptor activity8626535
GO:0034185IC-apolipoprotein binding8626535
GO:0038025ISS-reelin receptor activity-
GO ID Evidence Qualifier GO_term References
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter-
GO:0001523TAS-retinoid metabolic process-
GO:0006508NAS-proteolysis11152697
GO:0006629NAS-lipid metabolic process11152697
GO:0006897IDA-endocytosis8626535
GO:0006898IEA-receptor-mediated endocytosis-
GO:0007165TAS-signal transduction10380922
GO:0019221NAS-cytokine-mediated signaling pathway11152697
GO:0021541ISS-ammon gyrus development-
GO:0021987IEA-cerebral cortex development-
GO:0032793ISS-positive regulation of CREB transcription factor activity-
GO:0038026ISS-reelin-mediated signaling pathway-
GO:0042493IEA-response to drug-
GO:0050731ISS-positive regulation of peptidyl-tyrosine phosphorylation-
GO:0050804ISS-modulation of synaptic transmission-
GO:0061003ISS-positive regulation of dendritic spine morphogenesis-
GO:0061098ISS-positive regulation of protein tyrosine kinase activity-
GO:0071363IEA-cellular response to growth factor stimulus-
GO:0071397IEA-cellular response to cholesterol-
GO:1900006ISS-positive regulation of dendrite development-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LRP8APBA210681810827173 Two-hybrid
LRP8APBA211357910827173 Two-hybrid
LRP8APOE10684512950167 Reconstituted Complex
LRP8APOE11357912950167 Reconstituted Complex
LRP8APOH11357912807892 Affinity Capture-Western
LRP8APOH10684712807892 Affinity Capture-Western
LRP8DAB111357910827173 Two-hybrid
LRP8DAB110797010827173 Two-hybrid
LRP8DLG411357910827173 Two-hybrid
LRP8DLG410808610827173 Two-hybrid
LRP8LRPAP111357912899622 Reconstituted Complex
LRP8LRPAP111022112899622 Reconstituted Complex
LRP8RELN11357912670700 12899622 Affinity Capture-Western; Reconstituted Complex
LRP8RELN11163012670700 12899622 Affinity Capture-Western; Reconstituted Complex
LRP8SCN3A11223310827173 Two-hybrid
LRP8SCN3A11357910827173 Two-hybrid
ANAPC10LRP811566510827173 Two-hybrid
ANAPC10LRP811357910827173 Two-hybrid
GIPC1LRP811597810827173 Two-hybrid
GIPC1LRP811357910827173 Two-hybrid
MAPK8IP2LRP811357910827173 Two-hybrid
MAPK8IP2LRP811708610827173 Two-hybrid
SYNJ2BPLRP812061410827173 Two-hybrid
SYNJ2BPLRP811357910827173 Two-hybrid
ITGB1BP1LRP811468910827173 Two-hybrid
ITGB1BP1LRP811357910827173 Two-hybrid
MAPK8IP1LRP811486410827173 Two-hybrid
MAPK8IP1LRP811357910827173 Two-hybrid
NOS1APLRP811507110827173 Two-hybrid
NOS1APLRP811357910827173 Two-hybrid
SNX17LRP811512812169628 Affinity Capture-Western; Reconstituted Complex
SNX17LRP811357912169628 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
LRP8rs17108177, rs3737983, rs3820198, rs5174 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
LRP8rs11578993, rs1288480, rs1288489, rs1288516, rs1572262, rs2782491, rs2782497, rs3820198, rs5174, rs6694764, rs915191 Gene overview in PDGene
No data
Animal Model Top
No data