AutismKB 2.0

Annotation Details for CXCR4


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Basic Information Top
Gene Symbol:CXCR4 ( CD184,D2S201E,FB22,HM89,HSY3RR,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM )
Gene Full Name: chemokine (C-X-C motif) receptor 4
Band: 2q22.1
Quick LinksEntrez ID:7852; OMIM: 162643; Uniprot ID:CXCR4_HUMAN; ENSEMBL ID: ENSG00000121966; HGNC ID: 2561
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737TAS-cytoplasm10415069
GO:0005764IDA-lysosome21540189
GO:0005769IDA-early endosome21540189
GO:0005770IDA-late endosome21540189
GO:0005886IDA-plasma membrane21540189
GO:0005886TAS-plasma membrane-
GO:0009986IDA-cell surface10521508
GO:0016021IEA-integral component of membrane-
GO:0030054IEA-cell junction-
GO:0031252IDA-cell leading edge12421915
GO:0031410IDA-cytoplasmic vesicle10521508
GO:0043234IMP-protein complex25612609
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0001618IEA-virus receptor activity-
GO:0003779IDA-actin binding12421915
GO:0004930TAS-G-protein coupled receptor activity8276799
GO:0005515IPI-protein binding10644702
GO:0015026TAS-coreceptor activity10754293
GO:0016494NAS-C-X-C chemokine receptor activity9468539
GO:0019957IPI-C-C chemokine binding25612609
GO:0031625IPI-ubiquitin protein ligase binding19116316
GO:0032027IDA-myosin light chain binding12421915
GO:0043130IDA-ubiquitin binding20228059
GO ID Evidence Qualifier GO_term References
GO:0000187TAS-activation of MAPK activity10570282
GO:0001666IEP-response to hypoxia15174142
GO:0002407TAS-dendritic cell chemotaxis16621978
GO:0006915TAS-apoptotic process10942389
GO:0006954TAS-inflammatory response8276799
GO:0007186IDA-G-protein coupled receptor signaling pathway10644702
GO:0007204TAS-positive regulation of cytosolic calcium ion concentration10228019
GO:0009615TAS-response to virus10583963
GO:0019064TAS-fusion of virus membrane with host plasma membrane-
GO:0019722IMP-calcium-mediated signaling19064997
GO:0030260TAS-entry into host cell-
GO:0043217ISS-myelin maintenance-
GO:0048714ISS-positive regulation of oligodendrocyte differentiation-
GO:0050920IMP-regulation of chemotaxis19106094
GO:0070098IEA-chemokine-mediated signaling pathway-
GO:0071345IDA-cellular response to cytokine stimulus21540189
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CXCR4ADRBK210666611668182 Affinity Capture-Western
CXCR4ADRBK211360711668182 Affinity Capture-Western
CXCR4CD410735810816381 Affinity Capture-Western
CXCR4CD411360710816381 Affinity Capture-Western
CXCR4CCR511360712429730 Reconstituted Complex
CXCR4CCR510763912429730 Reconstituted Complex
CXCR4JAK211360710506573 Affinity Capture-Western
CXCR4JAK210992010506573 Affinity Capture-Western
CXCR4JAK311360710506573 Affinity Capture-Western
CXCR4JAK310992110506573 Affinity Capture-Western
CXCR4PTK211171911668182 Affinity Capture-Western
CXCR4PTK211360711668182 Affinity Capture-Western
CXCR4PTPN611174210506573 Affinity Capture-Western
CXCR4PTPN611360710506573 Affinity Capture-Western
CXCR4UBC11360711641392 14602072 17947233 Affinity Capture-Western
CXCR4UBC11316411641392 14602072 17947233 Affinity Capture-Western
SOCS3CXCR411448812163560 Affinity Capture-Western
SOCS3CXCR411360712163560 Affinity Capture-Western
USP14CXCR411360719106094 Affinity Capture-Western; Reconstituted Complex
USP14CXCR411455119106094 Affinity Capture-Western; Reconstituted Complex
ITCHCXCR411360719116316 Affinity Capture-Western; FRET; Reconstituted Complex
ITCHCXCR412374719116316 Affinity Capture-Western; FRET; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109563
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010614-1'