AutismKB 2.0

Annotation Details for DERL1


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Basic Information Top
Gene Symbol:DERL1 ( DER-1,DER1,FLJ13784,FLJ42092,MGC3067,PRO2577 )
Gene Full Name: Der1-like domain family, member 1
Band: 8q24.13
Quick LinksEntrez ID:79139; OMIM: 608813; Uniprot ID:DERL1_HUMAN; ENSEMBL ID: ENSG00000136986; HGNC ID: 28454
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005769IEA-early endosome-
GO:0005770IEA-late endosome-
GO:0005783IDA-endoplasmic reticulum15215855
GO:0005783IMP-endoplasmic reticulum16449189
GO:0005785IDAcolocalizes_withsignal recognition particle receptor complex26565908
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0016020IDA-membrane19946888
GO:0016021IDA-integral component of membrane15215855
GO:0030176IDA-integral component of endoplasmic reticulum membrane15215856
GO:0034098TAScolocalizes_withVCP-NPL4-UFD1 AAA ATPase complex16186510
GO:0036502IDA-Derlin-1-VIMP complex15215856
GO:0036513IDA-Derlin-1 retrotranslocation complex15215856
GO:0043657IEA-host cell-
GO:0048500IDAcolocalizes_withsignal recognition particle26565908
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding25239945
GO:0004252IEA-serine-type endopeptidase activity-
GO:0004872NAS-receptor activity15215856
GO:0005515IPI-protein binding15215856
GO:0031625IPI-ubiquitin protein ligase binding24019521
GO:0042288IDA-MHC class I protein binding15215855
GO:0051117IPI-ATPase binding16186510
GO:1990381IPI-ubiquitin-specific protease binding17000876
GO ID Evidence Qualifier GO_term References
GO:0006457TAS-protein folding-
GO:0006986IMP-response to unfolded protein15215855
GO:0016567TAS-protein ubiquitination-
GO:0019060TAS-intracellular transport of viral protein in host cell15215856
GO:0030433IDA-ubiquitin-dependent ERAD pathway15215856
GO:0030433IMP-ubiquitin-dependent ERAD pathway18555783
GO:0030433TAS-ubiquitin-dependent ERAD pathway22013210
GO:0030968IDA-endoplasmic reticulum unfolded protein response15215856
GO:0030970IDA-retrograde protein transport, ER to cytosol15215856
GO:0030970IMP-retrograde protein transport, ER to cytosol15215855
GO:0031398IDA-positive regulation of protein ubiquitination24089527
GO:0031648IMP-protein destabilization25239945
GO:0032092IMP-positive regulation of protein binding24089527
GO:0036503IMP-ERAD pathway25239945
GO:0045184TAS-establishment of protein localization15215856
GO:0051260IDA-protein homooligomerization16186510
GO:0055085TAS-transmembrane transport-
GO:0071712IMP-ER-associated misfolded protein catabolic process24089527
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DERL1AMFR12255916186510 17872946 18216283 Affinity Capture-Western
DERL1AMFR10676416186510 17872946 18216283 Affinity Capture-Western
DERL1CD3D12255917872946 Affinity Capture-Western
DERL1CD3D10735317872946 Affinity Capture-Western
DERL1HLA-A12255915215855 Affinity Capture-Western
DERL1HLA-A10935015215855 Affinity Capture-Western
DERL1SEL1L11230016186509 Affinity Capture-Western
DERL1SEL1L12255916186509 Affinity Capture-Western
DERL1VCP12255916186509 16186510 16289116 17872946 18199748 Affinity Capture-Western; Reconstituted Complex
DERL1VCP11325816186509 16186510 16289116 17872946 18199748 Affinity Capture-Western; Reconstituted Complex
DERL1RNF10312255918675248 Affinity Capture-Western
DERL1RNF10311360118675248 Affinity Capture-Western
DERL1HERPUD112255916289116 Affinity Capture-Western; Co-fractionation
DERL1HERPUD111506016289116 Affinity Capture-Western; Co-fractionation
DERL1DERL212255916186509 Affinity Capture-Western
DERL1DERL211921616186509 Affinity Capture-Western
DERL1SELS12093415215856 16186509 16186510 16289116 17872946 Affinity Capture-Western; Reconstituted Complex
DERL1SELS12255915215856 16186509 16186510 16289116 17872946 Affinity Capture-Western; Reconstituted Complex
SYVN1DERL112255916186510 16289116 Affinity Capture-Western; Reconstituted Complex
SYVN1DERL112408516186510 16289116 Affinity Capture-Western; Reconstituted Complex
SVIPDERL112255917872946 Affinity Capture-Western; Co-fractionation
SVIPDERL112922217872946 Affinity Capture-Western; Co-fractionation
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1915069
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2793'