AutismKB 2.0

Annotation Details for CDC73


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Basic Information Top
Gene Symbol:CDC73 ( C1orf28,FLJ23316,HPTJT,HRPT2,HYX )
Gene Full Name: cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Band: 1q31.2
Quick LinksEntrez ID:79577; OMIM: 607393; Uniprot ID:CDC73_HUMAN; ENSEMBL ID: ENSG00000134371; HGNC ID: 16783
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000784IDA-nuclear chromosome, telomeric region19135898
GO:0005634IDA-nucleus15923622
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0016593IDA-Cdc73/Paf1 complex16307923
GO ID Evidence Qualifier GO_term References
GO:0000993IDA-RNA polymerase II core binding15923622
GO:0001076IBA-transcription factor activity, RNA polymerase II transcription factor binding-
GO:0005515IPI-protein binding15923622
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter18987311
GO:0001558IEA-regulation of cell growth-
GO:0001711ISS-endodermal cell fate commitment-
GO:0006366TAS-transcription from RNA polymerase II promoter-
GO:0006368TAS-transcription elongation from RNA polymerase II promoter-
GO:0006378IMP-mRNA polyadenylation21329879
GO:0007049IEA-cell cycle-
GO:0008285IDA-negative regulation of cell proliferation16989776
GO:0010390IDA-histone monoubiquitination16307923
GO:0016055IEA-Wnt signaling pathway-
GO:0016567TAS-protein ubiquitination-
GO:0019827ISS-stem cell population maintenance-
GO:0030177IDA-positive regulation of Wnt signaling pathway16630820
GO:0031442IMP-positive regulation of mRNA 3'-end processing19136632
GO:0031648IMP-protein destabilization18987311
GO:0032968IDA-positive regulation of transcription elongation from RNA polymerase II promoter20178742
GO:0033523IDA-histone H2B ubiquitination16307923
GO:0034402IBA-recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0045638IDA-negative regulation of myeloid cell differentiation20541477
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter20178742
GO:0048147IMP-negative regulation of fibroblast proliferation18987311
GO:0050680IMP-negative regulation of epithelial cell proliferation18987311
GO:0071222ISS-cellular response to lipopolysaccharide-
GO:1904837TAS-beta-catenin-TCF complex assembly-
GO:2000134IDA-negative regulation of G1/S transition of mitotic cell cycle16989776
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CDC73ANXA612272416169070 Two-hybrid
CDC73ANXA610680616169070 Two-hybrid
CDC73CDK912272417643375 Affinity Capture-MS
CDC73CDK910745917643375 Affinity Capture-MS
CDC73GC12272416169070 Two-hybrid
CDC73GC10890816169070 Two-hybrid
CDC73HSPA412272416169070 Two-hybrid
CDC73HSPA410954016169070 Two-hybrid
CDC73KCNH212272416169070 Two-hybrid
CDC73KCNH210995916169070 Two-hybrid
CDC73POLR2A12272415632063 Affinity Capture-Western
CDC73POLR2A11142615632063 Affinity Capture-Western
CDC73RANBP212272415632063 Affinity Capture-MS
CDC73RANBP211183915632063 Affinity Capture-MS
CDC73CTR912272415632063 18469135 Affinity Capture-MS; Affinity Capture-Western
CDC73CTR911500415632063 18469135 Affinity Capture-MS; Affinity Capture-Western
CDC73WWC112272416169070 Two-hybrid
CDC73WWC111688416169070 Two-hybrid
CDC73PAF112272415632063 18469135 Affinity Capture-MS; Affinity Capture-Western
CDC73PAF112008115632063 18469135 Affinity Capture-MS; Affinity Capture-Western
CDC73MEPCE12112217643375 Affinity Capture-MS
CDC73MEPCE12272417643375 Affinity Capture-MS
CDC73C1orf12812272416169070 Two-hybrid
CDC73C1orf12812136316169070 Two-hybrid
LEO1CDC7312581715632063 18469135 Affinity Capture-MS; Affinity Capture-Western
LEO1CDC7312272415632063 18469135 Affinity Capture-MS; Affinity Capture-Western
No data
Gene Symbol Interactant Interaction ID References Description
CDC73C1orf1280958116169070 -
CDC73C1orf1281371716169070 -
CDC73KIDINS2200958116169070 -
CDC73KIDINS2201723516169070 -
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2384876
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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