AutismKB 2.0

Annotation Details for LRRK1


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Basic Information Top
Gene Symbol:LRRK1 ( FLJ23119,FLJ27465,KIAA1790,RIPK6,Roco1 )
Gene Full Name: leucine-rich repeat kinase 1
Band: 15q26.3
Quick LinksEntrez ID:79705; OMIM: 610986; Uniprot ID:LRRK1_HUMAN; ENSEMBL ID: ENSG00000154237; HGNC ID: 18608
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IBA-cytoplasm-
GO:0005739IDA-mitochondrion-
GO:0005829IDA-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0004674IBA-protein serine/threonine kinase activity-
GO:0004871IBA-signal transducer activity-
GO:0005515IPI-protein binding19712061
GO:0005524IEA-ATP binding-
GO:0005525IEA-GTP binding-
GO:0042802IPI-identical protein binding19712061
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006468IBA-protein phosphorylation-
GO:0007264IEA-small GTPase mediated signal transduction-
GO:0035556IBA-intracellular signal transduction-
GO:0036035IEA-osteoclast development-
GO:0045453IEA-bone resorption-
GO:0050731IEA-positive regulation of peptidyl-tyrosine phosphorylation-
GO:0050732IEA-negative regulation of peptidyl-tyrosine phosphorylation-
GO:0090263IGI-positive regulation of canonical Wnt signaling pathway22899650
GO:1902533IEA-positive regulation of intracellular signal transduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LRRK1LYZ12282317353931 Affinity Capture-MS
LRRK1LYZ11024717353931 Affinity Capture-MS
LRRK1S100A811218717353931 Affinity Capture-MS
LRRK1S100A812282317353931 Affinity Capture-MS
LRRK1PAK411558617353931 Affinity Capture-MS
LRRK1PAK412282317353931 Affinity Capture-MS
LRRK1RIMS112282317353931 Affinity Capture-MS
LRRK1RIMS111664617353931 Affinity Capture-MS
C9orf163LRRK112282317353931 Affinity Capture-MS
C9orf163LRRK112764217353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
LRRK1rs11247253, rs11630691, rs11853661, rs11857803, rs17161161, rs2278953, rs2412000, rs2924835, rs2925203, rs3764739, rs41319544, rs41339845, rs41372244, rs41381646, rs4965778, rs55739947, rs55798315, rs56215707, rs7169323 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:2142227
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-101019-2'