AutismKB 2.0

Annotation Details for NR4A3


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Basic Information Top
Gene Symbol:NR4A3 ( CHN,CSMF,MINOR,NOR1,TEC )
Gene Full Name: nuclear receptor subfamily 4, group A, member 3
Band: 9q22
Quick LinksEntrez ID:8013; OMIM: 600542; Uniprot ID:NR4A3_HUMAN; ENSEMBL ID: ENSG00000119508; HGNC ID: 7982
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634NAS-nucleus8634690
GO:0005654TAS-nucleoplasm-
GO:0005667IEA-transcription factor complex-
GO:0042629IEA-mast cell granule-
GO ID Evidence Qualifier GO_term References
GO:0000978IEA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0001046ISS-core promoter sequence-specific DNA binding-
GO:0001077IDA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding20558821
GO:0001223IEA-transcription coactivator binding-
GO:0003677NAS-DNA binding8634690
GO:0003707IEA-steroid hormone receptor activity-
GO:0004887TAS-thyroid hormone receptor activity8570200
GO:0005515IPI-protein binding12543801
GO:0008270IEA-zinc ion binding-
GO:0019901IPI-protein kinase binding25852083
GO:0035035IEA-histone acetyltransferase binding-
GO:0035259IEA-glucocorticoid receptor binding-
GO:0042803ISS-protein homodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter-
GO:0001707IEA-mesoderm formation-
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0007369ISS-gastrulation-
GO:0007411IEA-axon guidance-
GO:0008150ND-biological_process-
GO:0009444ISS-pyruvate oxidation-
GO:0010613ISS-positive regulation of cardiac muscle hypertrophy-
GO:0010828IDA-positive regulation of glucose transport24022864
GO:0021766IEA-hippocampus development-
GO:0030522IEA-intracellular receptor signaling pathway-
GO:0030534IEA-adult behavior-
GO:0031100IEA-animal organ regeneration-
GO:0032765ISS-positive regulation of mast cell cytokine production-
GO:0035726ISS-common myeloid progenitor cell proliferation-
GO:0038097ISS-positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway-
GO:0042542IEA-response to hydrogen peroxide-
GO:0043303ISS-mast cell degranulation-
GO:0043401IEA-steroid hormone mediated signaling pathway-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0044320ISS-cellular response to leptin stimulus-
GO:0045333ISS-cellular respiration-
GO:0045444ISS-fat cell differentiation-
GO:0045787IEA-positive regulation of cell cycle-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter20558821
GO:0046321ISS-positive regulation of fatty acid oxidation-
GO:0048660IDA-regulation of smooth muscle cell proliferation25852083
GO:0048661ISS-positive regulation of smooth muscle cell proliferation-
GO:0048752IEA-semicircular canal morphogenesis-
GO:0050679ISS-positive regulation of epithelial cell proliferation-
GO:0050885IEA-neuromuscular process controlling balance-
GO:0060005IEA-vestibular reflex-
GO:0061469ISS-regulation of type B pancreatic cell proliferation-
GO:0071376ISS-cellular response to corticotropin-releasing hormone stimulus-
GO:0071870ISS-cellular response to catecholamine stimulus-
GO:0097009ISS-energy homeostasis-
GO:1900625IMP-positive regulation of monocyte aggregation20558821
GO:1903208ISS-negative regulation of hydrogen peroxide-induced neuron death-
GO:2000108IEA-positive regulation of leukocyte apoptotic process-
GO:2000253ISS-positive regulation of feeding behavior-
GO:2000505ISS-regulation of energy homeostasis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NR4A3SIX311371311173923 12543801 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NR4A3SIX311238711173923 12543801 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRIM28NR4A311545719321449 Reconstituted Complex
TRIM28NR4A311371319321449 Reconstituted Complex
KDM5BNR4A311598419336002 Affinity Capture-MS
KDM5BNR4A311371319336002 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
NR4A3rs1131339, rs1405209 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1352457
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070824-4'