AutismKB 2.0

Annotation Details for CDK5RAP3


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Basic Information Top
Gene Symbol:CDK5RAP3 ( C53,HSF-27,IC53,LZAP,MST016,OK/SW-cl.114 )
Gene Full Name: CDK5 regulatory subunit associated protein 3
Band: 17q21.32
Quick LinksEntrez ID:80279; OMIM: 608202; Uniprot ID:CK5P3_HUMAN; ENSEMBL ID: ENSG00000108465; HGNC ID: 18673
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16173922
GO:0005730IDA-nucleolus-
GO:0005730IDANOTnucleolus16173922
GO:0005737IDA-cytoplasm15790566
GO:0005813IDA-centrosome19223857
GO:0005829IDA-cytosol-
GO:0005874IDAcolocalizes_withmicrotubule23478299
GO:0012505IBA-endomembrane system-
GO:0016020IDA-membrane19946888
GO:0043234IDA-protein complex20531390
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding16173922
GO:0019901IPI-protein kinase binding19223857
GO:0019901NAS-protein kinase binding10721722
GO:0030332IPI-cyclin binding15790566
GO:0044389IDA-ubiquitin-like protein ligase binding20531390
GO:0051019IPI-mitogen-activated protein kinase binding21283629
GO:0051059IPI-NF-kappaB binding17785205
GO:0097371IPI-MDM2/MDM4 family protein binding16173922
GO ID Evidence Qualifier GO_term References
GO:0000079ISS-regulation of cyclin-dependent protein serine/threonine kinase activity-
GO:0001933IMP-negative regulation of protein phosphorylation17785205
GO:0007095IMP-mitotic G2 DNA damage checkpoint15790566
GO:0007420NAS-brain development10915792
GO:0008283IDA-cell proliferation12054757
GO:0010921IMP-regulation of phosphatase activity21283629
GO:0030262IMP-apoptotic nuclear changes23478299
GO:0030968IMP-endoplasmic reticulum unfolded protein response23152784
GO:0031398IDA-positive regulation of protein ubiquitination16173922
GO:0032088IMP-negative regulation of NF-kappaB transcription factor activity17785205
GO:0043407IMP-negative regulation of MAP kinase activity21283629
GO:0044387IMP-negative regulation of protein kinase activity by regulation of protein phosphorylation21283629
GO:0044818IMP-mitotic G2/M transition checkpoint19223857
GO:0045664NAS-regulation of neuron differentiation10721722
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0071569IDA-protein ufmylation23152784
GO:0071901IMP-negative regulation of protein serine/threonine kinase activity19223857
GO:1900182IDA-positive regulation of protein localization to nucleus16173922
GO:1901798IDA-positive regulation of signal transduction by p53 class mediator16173922
GO:1903363IDA-negative regulation of cellular protein catabolic process16173922
GO:2000060IDANOTpositive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process16173922
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CDK5RAP3ARL110689317353931 Affinity Capture-MS
CDK5RAP3ARL112321317353931 Affinity Capture-MS
CDK5RAP3CRMP110779016169070 Two-hybrid
CDK5RAP3CRMP112321316169070 Two-hybrid
CDK5RAP3IGHA110971417353931 Affinity Capture-MS
CDK5RAP3IGHA112321317353931 Affinity Capture-MS
CDK5RAP3IGKC10973417353931 Affinity Capture-MS
CDK5RAP3IGKC12321317353931 Affinity Capture-MS
CDK5RAP3KHK12321317353931 Affinity Capture-MS
CDK5RAP3KHK10999617353931 Affinity Capture-MS
CDK5RAP3CDK5R112321310915792 Reconstituted Complex
CDK5RAP3CDK5R111437610915792 Reconstituted Complex
CDK5RAP3SMNDC111557417353931 Affinity Capture-MS
CDK5RAP3SMNDC112321317353931 Affinity Capture-MS
CDK5RAP3KIAA077611695317353931 Affinity Capture-MS
CDK5RAP3KIAA077612321317353931 Affinity Capture-MS
CDK5RAP3UFC111957717353931 Affinity Capture-MS
CDK5RAP3UFC112321317353931 Affinity Capture-MS
CDK5RAP3UFM111961617353931 Affinity Capture-MS
CDK5RAP3UFM112321317353931 Affinity Capture-MS
CDK5RAP3DDRGK112244117353931 Affinity Capture-MS
CDK5RAP3DDRGK112321317353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1933126
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040625-90'