AutismKB 2.0

Annotation Details for CUBN


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Basic Information Top
Gene Symbol:CUBN ( FLJ90055,FLJ90747,IFCR,MGA1,gp280 )
Gene Full Name: cubilin (intrinsic factor-cobalamin receptor)
Band: 10p13
Quick LinksEntrez ID:8029; OMIM: 602997; Uniprot ID:CUBN_HUMAN; ENSEMBL ID: ENSG00000107611; HGNC ID: 2548
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005765IEA-lysosomal membrane-
GO:0005783IEA-endoplasmic reticulum-
GO:0005794IEA-Golgi apparatus-
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0005905IEA-clathrin-coated pit-
GO:0010008TAS-endosome membrane-
GO:0016020TAS-membrane9478979
GO:0016324IDA-apical plasma membrane14576052
GO:0030139IDA-endocytic vesicle14576052
GO:0031232NAS-extrinsic component of external side of plasma membrane11994745
GO:0031526NAS-brush border membrane11994745
GO:0043202TAS-lysosomal lumen-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0004872TAS-receptor activity10080186
GO:0005215TAS-transporter activity9478979
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding14576052
GO:0031419IEA-cobalamin binding-
GO:0042803IDA-protein homodimerization activity10552972
GO ID Evidence Qualifier GO_term References
GO:0001894NAS-tissue homeostasis11994745
GO:0006898NAS-receptor-mediated endocytosis11994745
GO:0008203IEA-cholesterol metabolic process-
GO:0009235TAS-cobalamin metabolic process-
GO:0015889TAS-cobalamin transport10080186
GO:0034384TAS-high-density lipoprotein particle clearance-
GO:0042359TAS-vitamin D metabolic process-
GO:0042953IEA-lipoprotein transport-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CUBNGC10890811717447 Affinity Capture-Western
CUBNGC11372411717447 Affinity Capture-Western
CUBNGIF1137249572993 Reconstituted Complex
CUBNGIF1089619572993 Reconstituted Complex
CUBNSCGB1A111372411278724 Reconstituted Complex
CUBNSCGB1A111320311278724 Reconstituted Complex
RRP1BCUBN11372419710015 Affinity Capture-MS
RRP1BCUBN11670819710015 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1931256
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060228-6'