AutismKB 2.0

Annotation Details for MLL2


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Basic Information Top
Gene Symbol:MLL2 ( AAD10,ALR,CAGL114,KMT2B,KMT2D,MLL4,TNRC21 )
Gene Full Name: myeloid/lymphoid or mixed-lineage leukemia 2
Band: 12q12-q14
Quick LinksEntrez ID:8085; OMIM: 602113; Uniprot ID:MLL2_HUMAN; ENSEMBL ID: ENSG00000167548; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634NAS-nucleus9247308
GO:0005654TAS-nucleoplasm-
GO:0035097IPI-histone methyltransferase complex14992727
GO:0044666IDA-MLL3/4 complex17500065
GO ID Evidence Qualifier GO_term References
GO:0003677NAS-DNA binding9247308
GO:0005515IPI-protein binding12482968
GO:0018024TAS-histone-lysine N-methyltransferase activity-
GO:0042800TAS-histone methyltransferase activity (H3-K4 specific)-
GO:0044212IDA-transcription regulatory region DNA binding16603732
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001555ISS-oocyte growth-
GO:0006342ISS-chromatin silencing-
GO:0006351IEA-transcription, DNA-templated-
GO:0006355NAS-regulation of transcription, DNA-templated9247308
GO:0008284IMP-positive regulation of cell proliferation16603732
GO:0033148IMP-positive regulation of intracellular estrogen receptor signaling pathway16603732
GO:0043627IDA-response to estrogen16603732
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter16603732
GO:0048477ISS-oogenesis-
GO:0051568ISS-histone H3-K4 methylation17178841
GO:1904837TAS-beta-catenin-TCF complex assembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MLL2CTNNB111375816510874 16510875 Reconstituted Complex
MLL2CTNNB110788016510874 16510875 Reconstituted Complex
MLL2E2F211375816951254 Affinity Capture-Western
MLL2E2F210820216951254 Affinity Capture-Western
MLL2E2F311375816951254 Affinity Capture-Western
MLL2E2F310820316951254 Affinity Capture-Western
MLL2E2F510820716951254 Affinity Capture-Western
MLL2E2F511375816951254 Affinity Capture-Western
MLL2E2F610820816951254 Affinity Capture-Western
MLL2E2F611375816951254 Affinity Capture-Western
MLL2MEF2D11037318026121 Affinity Capture-Western
MLL2MEF2D11375818026121 Affinity Capture-Western
MLL2POLR2A11375816199523 Reconstituted Complex
MLL2POLR2A11142616199523 Reconstituted Complex
MLL2RBBP511375815960974 17925232 Affinity Capture-Western
MLL2RBBP511186415960974 17925232 Affinity Capture-Western
MLL2KDM6A11375817761849 Affinity Capture-MS
MLL2KDM6A11324617761849 Affinity Capture-MS
WDR5MLL211375815960974 17925232 Affinity Capture-Western
WDR5MLL211627215960974 17925232 Affinity Capture-Western
SRRM1MLL211554416159877 Affinity Capture-MS
SRRM1MLL211375816159877 Affinity Capture-MS
PAXIP1MLL211375817925232 Affinity Capture-MS; Affinity Capture-Western
PAXIP1MLL211662517925232 Affinity Capture-MS; Affinity Capture-Western
ASH2LMLL211375817925232 Affinity Capture-Western
ASH2LMLL211452817925232 Affinity Capture-Western
CXXC1MLL211904518082152 Affinity Capture-Western
CXXC1MLL211375818082152 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2682319
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060223-2'