AutismKB 2.0

Annotation Details for HMGA2


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Basic Information Top
Gene Symbol:HMGA2 ( BABL,HMGI-C,HMGIC,LIPO,STQTL9 )
Gene Full Name: high mobility group AT-hook 2
Band: 12q14.3
Quick LinksEntrez ID:8091; OMIM: 600698; Uniprot ID:HMGA2_HUMAN; ENSEMBL ID: ENSG00000149948; HGNC ID: 5009
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000228ISS-nuclear chromosome-
GO:0005634IDA-nucleus16791210
GO:0005654TAS-nucleoplasm-
GO:0032993IDA-protein-DNA complex19465398
GO:0035985IDA-senescence-associated heterochromatin focus16901784
GO:0071141IDA-SMAD protein complex18832382
GO ID Evidence Qualifier GO_term References
GO:0000975IDA-regulatory region DNA binding17426251
GO:0000989IDAcontributes_totranscription factor activity, transcription factor binding18832382
GO:0001047IDA-core promoter binding14627817
GO:0001077IDA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding18832382
GO:0001078IDA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding14627817
GO:0003677NAS-DNA binding8198613
GO:0003680IDA-AT DNA binding14627817
GO:0003680IMP-AT DNA binding18832382
GO:0003906IDA-DNA-(apurinic or apyrimidinic site) lyase activity19465398
GO:0004677IDA-DNA-dependent protein kinase activity19549901
GO:0005515IPI-protein binding16293633
GO:0008134IPI-transcription factor binding14645522
GO:0008301IDA-DNA binding, bending20108983
GO:0008301IMP-DNA binding, bending14627817
GO:0031492IDA-nucleosomal DNA binding17078040
GO:0035497IDA-cAMP response element binding14645522
GO:0035500IDA-MH2 domain binding18832382
GO:0035501IDA-MH1 domain binding18832382
GO:0046332IPI-SMAD binding18832382
GO:0051575IDA-5'-deoxyribose-5-phosphate lyase activity19465398
GO:0070742IMP-C2H2 zinc finger domain binding14645522
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter14627817
GO:0001837IMP-epithelial to mesenchymal transition18832382
GO:0002062IDA-chondrocyte differentiation21484705
GO:0003131IMP-mesodermal-endodermal cell signaling17624332
GO:0006284IDA-base-excision repair19465398
GO:0006325TAS-chromatin organization19551524
GO:0006355IMP-regulation of transcription, DNA-templated7606786
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0007095IDA-mitotic G2 DNA damage checkpoint16061642
GO:0007275TAS-multicellular organism development7606786
GO:0009615IEP-response to virus17005673
GO:0010564IDA-regulation of cell cycle process14645522
GO:0010628IDA-positive regulation of gene expression18832382
GO:0030261IEA-chromosome condensation-
GO:0031052IDA-chromosome breakage19549901
GO:0031507IDA-heterochromatin assembly16901784
GO:0035978IDA-histone H2A-S139 phosphorylation16061642
GO:0035986IDA-senescence-associated heterochromatin focus assembly16901784
GO:0035987IMP-endodermal cell differentiation17624332
GO:0035988IDA-chondrocyte proliferation21484705
GO:0040008IEA-regulation of growth-
GO:0042769IDA-DNA damage response, detection of DNA damage19465398
GO:0043065IDA-positive regulation of apoptotic process16061642
GO:0043066IDA-negative regulation of apoptotic process19465398
GO:0043392IDA-negative regulation of DNA binding14645522
GO:0043922IDA-negative regulation by host of viral transcription17005673
GO:0045444IMP-fat cell differentiation7606786
GO:0045869IDA-negative regulation of single stranded viral RNA replication via double stranded DNA intermediate17005673
GO:0045892IDA-negative regulation of transcription, DNA-templated18832382
GO:0045892IMP-negative regulation of transcription, DNA-templated16901784
GO:0045893IDA-positive regulation of transcription, DNA-templated15225648
GO:0045893IMP-positive regulation of transcription, DNA-templated17624332
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter14645522
GO:0048333IMP-mesodermal cell differentiation17624332
GO:0048762IMP-mesenchymal cell differentiation7606786
GO:0048863IEP-stem cell differentiation17078040
GO:0051301IEA-cell division-
GO:0071158IDA-positive regulation of cell cycle arrest16061642
GO:0090402IDA-oncogene-induced cell senescence16901784
GO:2000036IMP-regulation of stem cell population maintenance17624332
GO:2000036TAS-regulation of stem cell population maintenance19551524
GO:2000648IDA-positive regulation of stem cell proliferation21484705
GO:2000648IMP-positive regulation of stem cell proliferation17624332
GO:2000679IDA-positive regulation of transcription regulatory region DNA binding18832382
GO:2000685IDA-positive regulation of cellular response to X-ray16061642
GO:2000774IMP-positive regulation of cellular senescence16901784
GO:2001022IDA-positive regulation of response to DNA damage stimulus16061642
GO:2001033IDA-negative regulation of double-strand break repair via nonhomologous end joining19549901
GO:2001038IDA-regulation of cellular response to drug16061642
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HMGA2SMAD111026118425117 Affinity Capture-Western
HMGA2SMAD111376318425117 Affinity Capture-Western
HMGA2SMAD511376318425117 Affinity Capture-Western
HMGA2SMAD511026518425117 Affinity Capture-Western
HMGA2SMAD911376318425117 Affinity Capture-Western
HMGA2SMAD911026818425117 Affinity Capture-Western
HMGA2NFKB111085712693954 Far Western; Reconstituted Complex
HMGA2NFKB111376312693954 Far Western; Reconstituted Complex
HMGA2NPM111376316293633 Far Western
HMGA2NPM111092916293633 Far Western
HMGA2PRKCA11376310889043 Biochemical Activity
HMGA2PRKCA11156410889043 Biochemical Activity
HMGA2RB111376316766265 Affinity Capture-Western; Far Western; Reconstituted Complex
HMGA2RB111186016766265 Affinity Capture-Western; Far Western; Reconstituted Complex
HMGA2RELA11376312693954 Reconstituted Complex
HMGA2RELA11190212693954 Reconstituted Complex
PIAS3HMGA211376311390395 Affinity Capture-Western; Two-hybrid
PIAS3HMGA211567311390395 Affinity Capture-Western; Two-hybrid
PRMT6HMGA211376316293633 Biochemical Activity; Far Western
PRMT6HMGA212046916293633 Biochemical Activity; Far Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:101761
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-3148'