AutismKB 2.0

Annotation Details for ACTN4


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Basic Information Top
Gene Symbol:ACTN4 ( ACTININ-4,DKFZp686K23158,FSGS,FSGS1 )
Gene Full Name: actinin, alpha 4
Band: 19q13.2
Quick LinksEntrez ID:81; OMIM: 604638; Uniprot ID:ACTN4_HUMAN; ENSEMBL ID: ENSG00000130402; HGNC ID: 166
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001725IEA-stress fiber-
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space16502470
GO:0005622IDA-intracellular21784188
GO:0005634IDA-nucleus9508771
GO:0005737IDA-cytoplasm9508771
GO:0005829IDA-cytosol-
GO:0005903IEA-brush border-
GO:0005911IEA-cell-cell junction-
GO:0005925IDA-focal adhesion21423176
GO:0015629IDAcolocalizes_withactin cytoskeleton25918384
GO:0016604IDA-nuclear body-
GO:0030018IEA-Z disc-
GO:0030529IDA-intracellular ribonucleoprotein complex17289661
GO:0030863IEA-cortical cytoskeleton-
GO:0031093TAS-platelet alpha granule lumen-
GO:0031143TAS-pseudopodium1629252
GO:0043005IEA-neuron projection-
GO:0043234IDA-protein complex11948184
GO:0048471IDA-perinuclear region of cytoplasm15619032
GO:0070062IDA-extracellular exosome19199708
GO ID Evidence Qualifier GO_term References
GO:0000977IDA-RNA polymerase II regulatory region sequence-specific DNA binding25411248
GO:0001882IDA-nucleoside binding12411747
GO:0003723IDA-RNA binding22658674
GO:0003779TAS-actin binding8104223
GO:0005178TAS-integrin binding8104223
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding15619032
GO:0030374IMP-ligand-dependent nuclear receptor transcription coactivator activity22351778
GO:0031490IDA-chromatin DNA binding25411248
GO:0035257IPI-nuclear hormone receptor binding22351778
GO:0042803IPI-protein homodimerization activity22351778
GO:0042803TAS-protein homodimerization activity15841212
GO:0042974IPI-retinoic acid receptor binding22351778
GO:0044325IPI-ion channel binding19943616
GO:0047485IEA-protein N-terminus binding-
GO:0051015IDA-actin filament binding12411747
GO:0051015IMP-actin filament binding25918384
GO ID Evidence Qualifier GO_term References
GO:0001666IEA-response to hypoxia-
GO:0002576TAS-platelet degranulation-
GO:0015031IEA-protein transport-
GO:0030050IMP-vesicle transport along actin filament25918384
GO:0030335IMP-positive regulation of cell migration25918384
GO:0032417NAS-positive regulation of sodium:proton antiporter activity11948184
GO:0035357IDA-peroxisome proliferator activated receptor signaling pathway22351778
GO:0042981NAS-regulation of apoptotic process16807302
GO:0048384IDA-retinoic acid receptor signaling pathway22351778
GO:0048549IEA-positive regulation of pinocytosis-
GO:0051017IEA-actin filament bundle assembly-
GO:0051271IEA-negative regulation of cellular component movement-
GO:0051272IDA-positive regulation of cellular component movement9508771
GO:0051272IMP-positive regulation of cellular component movement15048094
GO:0070830IEA-bicellular tight junction assembly-
GO:1900025IMP-negative regulation of substrate adhesion-dependent cell spreading25918384
GO:1901224IMP-positive regulation of NIK/NF-kappaB signaling25411248
GO:1902396IEA-protein localization to bicellular tight junction-
GO:1903506IMP-regulation of nucleic acid-templated transcription22351778
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TRIM3ACTN410659610673389 Affinity Capture-Western; Two-hybrid
TRIM3ACTN411585810673389 Affinity Capture-Western; Two-hybrid
PDLIM1ACTN410659610753915 16189514 Reconstituted Complex; Two-hybrid
PDLIM1ACTN411457210753915 16189514 Reconstituted Complex; Two-hybrid
CAMK2AACTN410659611160423 Two-hybrid
CAMK2AACTN410726511160423 Two-hybrid
CAMK2BACTN410659611160423 Two-hybrid
CAMK2BACTN410726611160423 Two-hybrid
GSNACTN410659611733011 Reconstituted Complex
GSNACTN410918911733011 Reconstituted Complex
COL17A1ACTN410659611739652 Affinity Capture-Western; Two-hybrid
COL17A1ACTN410770411739652 Affinity Capture-Western; Two-hybrid
SLC9A3R2ACTN410659611948184 Affinity Capture-Western; Reconstituted Complex
SLC9A3R2ACTN411475411948184 Affinity Capture-Western; Reconstituted Complex
MAGI1ACTN410659612042308 Affinity Capture-Western; Reconstituted Complex
MAGI1ACTN411465512042308 Affinity Capture-Western; Reconstituted Complex
USP6NLACTN410659615152255 Affinity Capture-Western
USP6NLACTN411506315152255 Affinity Capture-Western
MYOZ2ACTN411972616189514 Two-hybrid
MYOZ2ACTN410659616189514 Two-hybrid
MYOZ1ACTN410659616189514 Two-hybrid
MYOZ1ACTN412184916189514 Two-hybrid
MEF2AACTN410659616980305 Affinity Capture-Western; Reconstituted Complex
MEF2AACTN411036916980305 Affinity Capture-Western; Reconstituted Complex
HDAC7ACTN411961316980305 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HDAC7ACTN410659616980305 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
UBTFACTN411319020197409 Affinity Capture-Western
UBTFACTN410659620197409 Affinity Capture-Western
INO80ACTN412007620197409 Affinity Capture-Western; Reconstituted Complex
INO80ACTN410659620197409 Affinity Capture-Western; Reconstituted Complex
STAT1ACTN410659620936779 Two-hybrid
STAT1ACTN411264920936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
LRRC7ACTN425890811160423 LRRC7 (Densin-180) interacts with ACTN4 (alpha-Actinin 4). This interaction was modeled on a demonstrated interaction between rat LRCC7 and human ACTN4.
PDLIM1ACTN419369810753915 CLP-36 interacts with alpha-actinin 4.
CAMK2AACTN425890711160423 CAMK2A (CaMKII-alpha) interacts with ACTN4 (alpha-Actinin 4).
CAMK2BACTN425890611160423 CAMK2B (CaMKII-beta) interacts with ACTN4 (alpha-Actinin 4).
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1890773
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-940'