AutismKB 2.0

Annotation Details for CAMK2A


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Basic Information Top
Gene Symbol:CAMK2A ( CAMKA,KIAA0968 )
Gene Full Name: calcium/calmodulin-dependent protein kinase II alpha
Band: 5q32
Quick LinksEntrez ID:815; OMIM: 114078; Uniprot ID:KCC2A_HUMAN; ENSEMBL ID: ENSG00000070808; HGNC ID: 1460
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus21630459
GO:0005654TAS-nucleoplasm-
GO:0005737IBA-cytoplasm-
GO:0005739ISS-mitochondrion-
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0014069IEA-postsynaptic density-
GO:0030054IEA-cell junction-
GO:0030666TAS-endocytic vesicle membrane-
GO:0042734IEA-presynaptic membrane-
GO:0043005IBA-neuron projection-
GO ID Evidence Qualifier GO_term References
GO:0004674ISS-protein serine/threonine kinase activity-
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004683IBA-calmodulin-dependent protein kinase activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding17052756
GO:0005516IEA-calmodulin binding-
GO:0005524IEA-ATP binding-
GO:0009931IEA-calcium-dependent protein serine/threonine kinase activity-
GO:0016301IDA-kinase activity17052756
GO:0035254ISS-glutamate receptor binding-
GO:0042803IPI-protein homodimerization activity20668654
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000082ISS-G1/S transition of mitotic cell cycle-
GO:0000165TAS-MAPK cascade-
GO:0002931ISS-response to ischemia-
GO:0006468IDA-protein phosphorylation17052756
GO:0006816ISS-calcium ion transport-
GO:0007223TAS-Wnt signaling pathway, calcium modulating pathway-
GO:0007399IBA-nervous system development-
GO:0010666ISS-positive regulation of cardiac muscle cell apoptotic process-
GO:0018105IBA-peptidyl-serine phosphorylation-
GO:0018105ISS-peptidyl-serine phosphorylation-
GO:0018107IBA-peptidyl-threonine phosphorylation-
GO:0030154IBA-cell differentiation-
GO:0035556IBA-intracellular signal transduction-
GO:0038166IDA-angiotensin-activated signaling pathway20584908
GO:0043547IEA-positive regulation of GTPase activity-
GO:0046777ISS-protein autophosphorylation-
GO:0046928ISS-regulation of neurotransmitter secretion-
GO:0048168ISS-regulation of neuronal synaptic plasticity-
GO:0048813IEA-dendrite morphogenesis-
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity17052756
GO:0051928ISS-positive regulation of calcium ion transport-
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:1900034TAS-regulation of cellular response to heat-
GO:1902108ISS-regulation of mitochondrial membrane permeability involved in apoptotic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CAMK2AACTN410659611160423 Two-hybrid
CAMK2AACTN410726511160423 Two-hybrid
CAMK2AATF11069568663317 Biochemical Activity
CAMK2AATF11072658663317 Biochemical Activity
CAMK2ACALM310725917353931 Affinity Capture-MS
CAMK2ACALM310726517353931 Affinity Capture-MS
CREB1CAMK2A1077758663317 Biochemical Activity
CREB1CAMK2A1072658663317 Biochemical Activity
GRIN2BCAMK2A10916111459059 Reconstituted Complex
GRIN2BCAMK2A10726511459059 Reconstituted Complex
PARK2CAMK2A11110511679592 Affinity Capture-Western
PARK2CAMK2A10726511679592 Affinity Capture-Western
CDK5R1CAMK2A11437612223541 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDK5R1CAMK2A10726512223541 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABCAMK2A11336112619878 Biochemical Activity
YWHABCAMK2A10726512619878 Biochemical Activity
RIMS1CAMK2A11664612871946 Biochemical Activity
RIMS1CAMK2A10726512871946 Biochemical Activity
DLG1CAMK2A10808312933808 Affinity Capture-Western; Biochemical Activity
DLG1CAMK2A10726512933808 Affinity Capture-Western; Biochemical Activity
DLG3CAMK2A10808517353931 Affinity Capture-MS
DLG3CAMK2A10726517353931 Affinity Capture-MS
CHMP5CAMK2A11957917353931 Affinity Capture-MS
CHMP5CAMK2A10726517353931 Affinity Capture-MS
CAMK2BCAMK2A10726617353931 Affinity Capture-MS
CAMK2BCAMK2A10726517353931 Affinity Capture-MS
CAMK2DCAMK2A10726717353931 Affinity Capture-MS
CAMK2DCAMK2A10726517353931 Affinity Capture-MS
HDAC5CAMK2A11533118292392 Affinity Capture-Western
HDAC5CAMK2A10726518292392 Affinity Capture-Western
YWHAQCAMK2A11616818292392 Affinity Capture-Western
YWHAQCAMK2A10726518292392 Affinity Capture-Western
GIT1CAMK2A11878918292392 Affinity Capture-Western
GIT1CAMK2A10726518292392 Affinity Capture-Western
PLCG1CAMK2A11135118292392 Affinity Capture-Western
PLCG1CAMK2A10726518292392 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
CAMK2AACTN425890711160423 CAMK2A (CaMKII-alpha) interacts with ACTN4 (alpha-Actinin 4).
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88256
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-051113-72'