AutismKB 2.0

Annotation Details for KDM5C


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Basic Information Top
Gene Symbol:KDM5C ( DXS1272E,JARID1C,MRXJ,MRXSJ,SMCX,XE169 )
Gene Full Name: lysine (K)-specific demethylase 5C
Band: Xp11.22
Quick LinksEntrez ID:8242; OMIM: 314690; Uniprot ID:KDM5C_HUMAN; ENSEMBL ID: ENSG00000126012; HGNC ID: 11114
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus18078810
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0016706IEA-oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors-
GO:0032452TAS-histone demethylase activity-
GO:0032453IDA-histone demethylase activity (H3-K4 specific)17320160
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006351IEA-transcription, DNA-templated-
GO:0009636IEA-response to toxic substance-
GO:0034720IDA-histone H3-K4 demethylation17320160
GO:0045892ISS-negative regulation of transcription, DNA-templated-
GO:0048511IEA-rhythmic process-
GO:0055114IEA-oxidation-reduction process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KDM5CE2F610820817468742 Affinity Capture-MS
KDM5CE2F611387017468742 Affinity Capture-MS
KDM5CHDAC111387017468742 Affinity Capture-MS
KDM5CHDAC110931517468742 Affinity Capture-MS
KDM5CHDAC211387017468742 Affinity Capture-MS
KDM5CHDAC210931617468742 Affinity Capture-MS
KDM5CSMAD311387018078810 Affinity Capture-Western
KDM5CSMAD311026318078810 Affinity Capture-Western
KDM5CMAX11387017468742 Affinity Capture-MS
KDM5CMAX11031917468742 Affinity Capture-MS
KDM5CREST11387017468742 Affinity Capture-MS
KDM5CREST11191017468742 Affinity Capture-MS
KDM5CRING111387017468742 Affinity Capture-MS
KDM5CRING111194717468742 Affinity Capture-MS
KDM5CRNF211197217468742 Affinity Capture-MS
KDM5CRNF211387017468742 Affinity Capture-MS
KDM5CUBE2D111387019346402 Biochemical Activity
KDM5CUBE2D111316919346402 Biochemical Activity
HIST2H3AKDM5C11387017320160 17320161 17468742 Biochemical Activity; Reconstituted Complex
HIST2H3AKDM5C13061617320160 17320161 17468742 Biochemical Activity; Reconstituted Complex
CBX3KDM5C11387017468742 Affinity Capture-MS
CBX3KDM5C11646317468742 Affinity Capture-MS
NCOR1KDM5C11387017468742 Affinity Capture-MS
NCOR1KDM5C11497317468742 Affinity Capture-MS
KDM5CKDM5C11387018078810 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99781
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018