AutismKB 2.0

Annotation Details for AXIN1


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Basic Information Top
Gene Symbol:AXIN1 ( AXIN,MGC52315 )
Gene Full Name: axin 1
Band: 16p13.3
Quick LinksEntrez ID:8312; OMIM: 603816; Uniprot ID:AXN1_HUMAN; ENSEMBL ID: ENSG00000103126; HGNC ID: 903
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus12072559
GO:0005737IDA-cytoplasm12072559
GO:0005829TAS-cytosol-
GO:0016328IDA-lateral plasma membrane12072559
GO:0030877IDA-beta-catenin destruction complex9601641
GO:0031410ISS-cytoplasmic vesicle-
GO:0048471IDA-perinuclear region of cytoplasm19038973
GO:0071944IDA-cell periphery19038973
GO ID Evidence Qualifier GO_term References
GO:0004871IDA-signal transducer activity9601641
GO:0005096IBA-GTPase activator activity-
GO:0005515IPI-protein binding9601641
GO:0008013IDA-beta-catenin binding10644691
GO:0019899IPI-enzyme binding19759537
GO:0019901ISS-protein kinase binding-
GO:0030159IEA-receptor signaling complex scaffold activity-
GO:0031625IPI-ubiquitin protein ligase binding16601693
GO:0032947IDA-protein complex scaffold9601641
GO:0032947IMP-protein complex scaffold16601693
GO:0042802ISS-identical protein binding-
GO:0042803ISS-protein homodimerization activity-
GO:0046332IPI-SMAD binding18593713
GO:0070016ISS-armadillo repeat domain binding-
GO:0070411IPI-I-SMAD binding16601693
GO ID Evidence Qualifier GO_term References
GO:0001743IBA-optic placode formation-
GO:0001934IDA-positive regulation of protein phosphorylation9601641
GO:0006915IEA-apoptotic process-
GO:0007257IBA-activation of JUN kinase activity-
GO:0007368IBA-determination of left/right symmetry-
GO:0010800NAS-positive regulation of peptidyl-threonine phosphorylation18593713
GO:0016055TAS-Wnt signaling pathway-
GO:0016579TAS-protein deubiquitination-
GO:0021797IBA-forebrain anterior/posterior pattern specification-
GO:0021881IBA-Wnt-activated signaling pathway involved in forebrain neuron fate commitment-
GO:0030178IDA-negative regulation of Wnt signaling pathway10644691
GO:0030910IBA-olfactory placode formation-
GO:0031122IBA-cytoplasmic microtubule organization-
GO:0031398NAS-positive regulation of protein ubiquitination18593713
GO:0032147IDA-activation of protein kinase activity9601641
GO:0033138NAS-positive regulation of peptidyl-serine phosphorylation18593713
GO:0034244IBA-negative regulation of transcription elongation from RNA polymerase II promoter-
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043623IDA-cellular protein complex assembly16601693
GO:0045599IBA-negative regulation of fat cell differentiation-
GO:0045732IC-positive regulation of protein catabolic process16188939
GO:0045732IDA-positive regulation of protein catabolic process9601641
GO:0045893IMP-positive regulation of transcription, DNA-templated16601693
GO:0046330ISS-positive regulation of JNK cascade-
GO:0048048IBA-embryonic eye morphogenesis-
GO:0048320IBA-axial mesoderm formation-
GO:0051443IMP-positive regulation of ubiquitin-protein transferase activity16601693
GO:0055001IBA-muscle cell development-
GO:0060070IC-canonical Wnt signaling pathway9601641
GO:0060272IBA-embryonic skeletal joint morphogenesis-
GO:0060823IBA-canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation-
GO:0090090IMP-negative regulation of canonical Wnt signaling pathway22899650
GO:0090263TAS-positive regulation of canonical Wnt signaling pathway-
GO:1904885TAS-beta-catenin destruction complex assembly-
GO:1904886TAS-beta-catenin destruction complex disassembly-
GO:2000060ISS-positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
AXIN1APC1139099734785 16199882 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AXIN1APC1068219734785 16199882 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AXIN1CRMP111390916169070 Two-hybrid
AXIN1CRMP110779016169070 Two-hybrid
AXIN1CSNK1A111390911884395 Affinity Capture-Western; Phenotypic Suppression
AXIN1CSNK1A110783611884395 Affinity Capture-Western; Phenotypic Suppression
AXIN1CSNK1E11390911884395 Affinity Capture-Western; Phenotypic Suppression
AXIN1CSNK1E10783811884395 Affinity Capture-Western; Phenotypic Suppression
AXIN1CTNNB11139099734785 12421363 12805222 16199882 18632848 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AXIN1CTNNB11078809734785 12421363 12805222 16199882 18632848 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AXIN1DAB211390912805222 Reconstituted Complex
AXIN1DAB210797112805222 Reconstituted Complex
AXIN1DAXX11390917210684 Affinity Capture-Western; Two-hybrid
AXIN1DAXX10798517210684 Affinity Capture-Western; Two-hybrid
AXIN1DVL110818810428961 18632848 Affinity Capture-Western
AXIN1DVL111390910428961 18632848 Affinity Capture-Western
AXIN1DVL211390910829020 Affinity Capture-Western
AXIN1DVL210818910829020 Affinity Capture-Western
AXIN1DVL311390912805222 Affinity Capture-Western
AXIN1DVL310819012805222 Affinity Capture-Western
AXIN1EEF1A111390916169070 Two-hybrid
AXIN1EEF1A110823716169070 Two-hybrid
AXIN1GAK10885316169070 Two-hybrid
AXIN1GAK11390916169070 Two-hybrid
AXIN1GSK3B1091879734785 12511557 16199882 18632848 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AXIN1GSK3B1139099734785 12511557 16199882 18632848 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AXIN1LRP511390911336703 18632848 Affinity Capture-Western
AXIN1LRP511022011336703 18632848 Affinity Capture-Western
AXIN1MAP3K111037810829020 11884395 Affinity Capture-Western
AXIN1MAP3K111390910829020 11884395 Affinity Capture-Western
AXIN1PPP2R5A11151711297546 Affinity Capture-Western; Reconstituted Complex
AXIN1PPP2R5A11390911297546 Affinity Capture-Western; Reconstituted Complex
AXIN1TSC111309912511557 Affinity Capture-Western
AXIN1TSC111390912511557 Affinity Capture-Western
AXIN1TSC211310012511557 Affinity Capture-Western
AXIN1TSC211390912511557 Affinity Capture-Western
AXIN1UBC11390918632848 Affinity Capture-Western
AXIN1UBC11316418632848 Affinity Capture-Western
AXIN1SUMO111318818632848 Reconstituted Complex
AXIN1SUMO111390918632848 Reconstituted Complex
AXIN1ANP32A11379116169070 Two-hybrid
AXIN1ANP32A11390916169070 Two-hybrid
AXIN1AXIN111390911884395 16169070 18632848 Affinity Capture-Western; Two-hybrid
UTP14AAXIN111602616169070 Two-hybrid
UTP14AAXIN111390916169070 Two-hybrid
SMYD2AXIN112127417353931 Affinity Capture-MS
SMYD2AXIN111390917353931 Affinity Capture-MS
FAM123BAXIN112655617510365 Reconstituted Complex
FAM123BAXIN111390917510365 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1096327
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000403-1'