AutismKB 2.0

Annotation Details for FZD1


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Basic Information Top
Gene Symbol:FZD1 ( DKFZp564G072,FLJ95923 )
Gene Full Name: frizzled homolog 1 (Drosophila)
Band: 7q21.13
Quick LinksEntrez ID:8321; OMIM: 603408; Uniprot ID:FZD1_HUMAN; ENSEMBL ID: ENSG00000157240; HGNC ID: 4038
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0009986IDA-cell surface19643732
GO:0016021IEA-integral component of membrane-
GO:1990909IC-Wnt signalosome10557084
GO ID Evidence Qualifier GO_term References
GO:0004930IEA-G-protein coupled receptor activity-
GO:0005102IPI-receptor binding14739301
GO:0005109IPI-frizzled binding19188438
GO:0005515IPI-protein binding19277043
GO:0017147IPI-Wnt-protein binding10557084
GO:0017147NAS-Wnt-protein binding23461676
GO:0030165IPI-PDZ domain binding19388021
GO:0042813IDA-Wnt-activated receptor activity10557084
GO:0042813NAS-Wnt-activated receptor activity23461676
GO:0042813TAS-Wnt-activated receptor activity24449494
GO ID Evidence Qualifier GO_term References
GO:0001934IEA-positive regulation of protein phosphorylation-
GO:0003149IEA-membranous septum morphogenesis-
GO:0003150IEA-muscular septum morphogenesis-
GO:0003151IEA-outflow tract morphogenesis-
GO:0007186IEA-G-protein coupled receptor signaling pathway-
GO:0007267IDA-cell-cell signaling10557084
GO:0030182ISS-neuron differentiation-
GO:0030514IEA-negative regulation of BMP signaling pathway-
GO:0030855IEA-epithelial cell differentiation-
GO:0035414IEA-negative regulation of catenin import into nucleus-
GO:0035425IDA-autocrine signaling10557084
GO:0042493IMP-response to drug19421142
GO:0044338IMP-canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation20039315
GO:0044339IMP-canonical Wnt signaling pathway involved in osteoblast differentiation20039315
GO:0045892IEA-negative regulation of transcription, DNA-templated-
GO:0045893IDA-positive regulation of transcription, DNA-templated18929644
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity10557084
GO:0060022IEA-hard palate development-
GO:0060070IDA-canonical Wnt signaling pathway10557084
GO:0060070IGI-canonical Wnt signaling pathway11433302
GO:0060070NAS-canonical Wnt signaling pathway23461676
GO:0060071TAS-Wnt signaling pathway, planar cell polarity pathway-
GO:0090179IEA-planar cell polarity pathway involved in neural tube closure-
GO:0099054TAS-presynapse assembly24449494
GO:1903204IEA-negative regulation of oxidative stress-induced neuron death-
GO:1904886TAS-beta-catenin destruction complex disassembly-
GO:1904953NAS-Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation23461676
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FZD1DLG411391712067714 Two-hybrid
FZD1DLG410808612067714 Two-hybrid
FZD1WNT5A11331110557084 Affinity Capture-Western
FZD1WNT5A11391710557084 Affinity Capture-Western
WNT3AFZD112459910557084 Affinity Capture-Western
WNT3AFZD111391710557084 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1196625
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990415-219'