AutismKB 2.0

Annotation Details for CASP2


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Basic Information Top
Gene Symbol:CASP2 ( CASP-2,ICH-1L,ICH-1L/1S,ICH1,NEDD2 )
Gene Full Name: caspase 2, apoptosis-related cysteine peptidase
Band: 7q34
Quick LinksEntrez ID:835; OMIM: 600639; Uniprot ID:CASP2_HUMAN; ENSEMBL ID: ENSG00000106144; HGNC ID: 1503
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634TAS-nucleus18309324
GO:0005737IBA-cytoplasm-
GO:0005739IEA-mitochondrion-
GO:0005829TAS-cytosol-
GO:0016020IEA-membrane-
GO ID Evidence Qualifier GO_term References
GO:0004197IDA-cysteine-type endopeptidase activity9044836
GO:0004197NAS-cysteine-type endopeptidase activity11156409
GO:0005515IPI-protein binding9560245
GO:0019899ISS-enzyme binding11076957
GO:0019904IPI-protein domain specific binding9044836
GO:0042802IPI-identical protein binding22531785
GO:0097200IBA-cysteine-type endopeptidase activity involved in execution phase of apoptosis-
GO ID Evidence Qualifier GO_term References
GO:0001554IEA-luteolysis-
GO:0003407IEA-neural retina development-
GO:0006915NAS-apoptotic process11156409
GO:0006919TAS-activation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0006977IMP-DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest21726810
GO:0007420IEA-brain development-
GO:0007568IEA-aging-
GO:0008630TAS-intrinsic apoptotic signaling pathway in response to DNA damage18309324
GO:0016485IDA-protein processing9044836
GO:0035234IEA-ectopic germ cell programmed cell death-
GO:0042981TAS-regulation of apoptotic process-
GO:0043065IDA-positive regulation of apoptotic process10980123
GO:0043066NAS-negative regulation of apoptotic process11156409
GO:0043525IEA-positive regulation of neuron apoptotic process-
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0097190TAS-apoptotic signaling pathway18309324
GO:0097192IEA-extrinsic apoptotic signaling pathway in absence of ligand-
GO:0097194TAS-execution phase of apoptosis18309324
GO:2001235IEA-positive regulation of apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CASP2XIAP10728511832478 Phenotypic Suppression
CASP2XIAP10682811832478 Phenotypic Suppression
CASP2BCL210728511832478 Phenotypic Suppression
CASP2BCL210706811832478 Phenotypic Suppression
CASP2BCL2L110728511832478 Phenotypic Suppression
CASP2BCL2L110707011832478 Phenotypic Suppression
CASP2BID10728511399776 11832478 Biochemical Activity
CASP2BID10710611399776 11832478 Biochemical Activity
CASP8CASP21072858962078 11832478 Biochemical Activity
CASP8CASP21072918962078 11832478 Biochemical Activity
CASP10CASP21072858962078 Biochemical Activity
CASP10CASP21072938962078 Biochemical Activity
TNFRSF1ACASP21072858985253 Affinity Capture-Western
TNFRSF1ACASP21129868985253 Affinity Capture-Western
CRADDCASP21142758985253 11156409 15073321 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
CRADDCASP21072858985253 11156409 15073321 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
NOL3CASP21072859560245 Affinity Capture-Western
NOL3CASP21144779560245 Affinity Capture-Western
CASP14CASP21072859792675 Affinity Capture-Western
CASP14CASP21171169792675 Affinity Capture-Western
NOD1CASP211566410329646 Affinity Capture-Western
NOD1CASP210728510329646 Affinity Capture-Western
NLRP1CASP210728511076957 Affinity Capture-Western
NLRP1CASP211652911076957 Affinity Capture-Western
CASP3CASP210728511399776 Biochemical Activity
CASP3CASP210728611399776 Biochemical Activity
CASP7CASP210728511399776 Biochemical Activity
CASP7CASP210729011399776 Biochemical Activity
CASP2CASP210728511832478 Biochemical Activity
CASP9CASP210728511832478 Phenotypic Suppression
CASP9CASP210729211832478 Phenotypic Suppression
CCND3CASP210728512011445 Two-hybrid
CCND3CASP210733612011445 Two-hybrid
LRDDCASP212064515073321 16360037 Affinity Capture-Western
LRDDCASP210728515073321 16360037 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97295
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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