Gene Symbol:	CASP2 ( CASP-2,ICH-1L,ICH-1L/1S,ICH1,NEDD2 )
Gene Full Name:	caspase 2, apoptosis-related cysteine peptidase
Band:	7q34
Quick Links	Entrez ID:835; OMIM: 600639; Uniprot ID:CASP2_HUMAN; ENSEMBL ID: ENSG00000106144; HGNC ID: 1503
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	TAS	-	nucleus	18309324
GO:0005737	IBA	-	cytoplasm	-
GO:0005739	IEA	-	mitochondrion	-
GO:0005829	TAS	-	cytosol	-
GO:0016020	IEA	-	membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0004197	IDA	-	cysteine-type endopeptidase activity	9044836
GO:0004197	NAS	-	cysteine-type endopeptidase activity	11156409
GO:0005515	IPI	-	protein binding	9560245
GO:0019899	ISS	-	enzyme binding	11076957
GO:0019904	IPI	-	protein domain specific binding	9044836
GO:0042802	IPI	-	identical protein binding	22531785
GO:0097200	IBA	-	cysteine-type endopeptidase activity involved in execution phase of apoptosis	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001554	IEA	-	luteolysis	-
GO:0003407	IEA	-	neural retina development	-
GO:0006915	NAS	-	apoptotic process	11156409
GO:0006919	TAS	-	activation of cysteine-type endopeptidase activity involved in apoptotic process	-
GO:0006977	IMP	-	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	21726810
GO:0007420	IEA	-	brain development	-
GO:0007568	IEA	-	aging	-
GO:0008630	TAS	-	intrinsic apoptotic signaling pathway in response to DNA damage	18309324
GO:0016485	IDA	-	protein processing	9044836
GO:0035234	IEA	-	ectopic germ cell programmed cell death	-
GO:0042981	TAS	-	regulation of apoptotic process	-
GO:0043065	IDA	-	positive regulation of apoptotic process	10980123
GO:0043066	NAS	-	negative regulation of apoptotic process	11156409
GO:0043525	IEA	-	positive regulation of neuron apoptotic process	-
GO:0071260	IEP	-	cellular response to mechanical stimulus	19593445
GO:0097190	TAS	-	apoptotic signaling pathway	18309324
GO:0097192	IEA	-	extrinsic apoptotic signaling pathway in absence of ligand	-
GO:0097194	TAS	-	execution phase of apoptosis	18309324
GO:2001235	IEA	-	positive regulation of apoptotic signaling pathway	-

Gene Symbol	Interactant	Interaction ID	References	Description
CASP2	XIAP	107285	11832478	Phenotypic Suppression
CASP2	XIAP	106828	11832478	Phenotypic Suppression
CASP2	BCL2	107285	11832478	Phenotypic Suppression
CASP2	BCL2	107068	11832478	Phenotypic Suppression
CASP2	BCL2L1	107285	11832478	Phenotypic Suppression
CASP2	BCL2L1	107070	11832478	Phenotypic Suppression
CASP2	BID	107285	11399776 11832478	Biochemical Activity
CASP2	BID	107106	11399776 11832478	Biochemical Activity
CASP8	CASP2	107285	8962078 11832478	Biochemical Activity
CASP8	CASP2	107291	8962078 11832478	Biochemical Activity
CASP10	CASP2	107285	8962078	Biochemical Activity
CASP10	CASP2	107293	8962078	Biochemical Activity
TNFRSF1A	CASP2	107285	8985253	Affinity Capture-Western
TNFRSF1A	CASP2	112986	8985253	Affinity Capture-Western
CRADD	CASP2	114275	8985253 11156409 15073321	Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
CRADD	CASP2	107285	8985253 11156409 15073321	Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
NOL3	CASP2	107285	9560245	Affinity Capture-Western
NOL3	CASP2	114477	9560245	Affinity Capture-Western
CASP14	CASP2	107285	9792675	Affinity Capture-Western
CASP14	CASP2	117116	9792675	Affinity Capture-Western
NOD1	CASP2	115664	10329646	Affinity Capture-Western
NOD1	CASP2	107285	10329646	Affinity Capture-Western
NLRP1	CASP2	107285	11076957	Affinity Capture-Western
NLRP1	CASP2	116529	11076957	Affinity Capture-Western
CASP3	CASP2	107285	11399776	Biochemical Activity
CASP3	CASP2	107286	11399776	Biochemical Activity
CASP7	CASP2	107285	11399776	Biochemical Activity
CASP7	CASP2	107290	11399776	Biochemical Activity
CASP2	CASP2	107285	11832478	Biochemical Activity
CASP9	CASP2	107285	11832478	Phenotypic Suppression
CASP9	CASP2	107292	11832478	Phenotypic Suppression
CCND3	CASP2	107285	12011445	Two-hybrid
CCND3	CASP2	107336	12011445	Two-hybrid
LRDD	CASP2	120645	15073321 16360037	Affinity Capture-Western
LRDD	CASP2	107285	15073321 16360037	Affinity Capture-Western

AutismKB 2.0

Annotation Details for CASP2

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics