AutismKB 2.0

Annotation Details for SESN2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SESN2 ( DKFZp761M0212,DKFZp761M02121,HI95,SES2,SEST2 )
Gene Full Name: sestrin 2
Band: 1p35.3
Quick LinksEntrez ID:83667; OMIM: 607767; Uniprot ID:SESN2_HUMAN; ENSEMBL ID: ENSG00000130766; HGNC ID: 20746
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005737IDA-cytoplasm15105503
GO:0005739IEA-mitochondrion-
GO:0005829TAS-cytosol-
GO:0031588ISScolocalizes_withnucleotide-activated protein kinase complex-
GO:0031932ISScolocalizes_withTORC2 complex-
GO:0061700IDAcolocalizes_withGATOR2 complex25263562
GO:1990316IDAcolocalizes_withATG1/ULK1 kinase complex25040165
GO ID Evidence Qualifier GO_term References
GO:0005092IEA-GDP-dissociation inhibitor activity-
GO:0005515IPI-protein binding15105503
GO:0016684IDA-oxidoreductase activity, acting on peroxide as acceptor26612684
GO:0032542IDA-sulfiredoxin activity15105503
GO:0032542IDANOTsulfiredoxin activity19113821
GO:0070728IDA-leucine binding26449471
GO ID Evidence Qualifier GO_term References
GO:0001932IDA-regulation of protein phosphorylation25040165
GO:0006635IEA-fatty acid beta-oxidation-
GO:0009749IEA-response to glucose-
GO:0016239IMP-positive regulation of macroautophagy23274085
GO:0030308ISS-negative regulation of cell growth-
GO:0030330IMP-DNA damage response, signal transduction by p53 class mediator18692468
GO:0032042IEA-mitochondrial DNA metabolic process-
GO:0032868IEA-response to insulin-
GO:0034198IMP-cellular response to amino acid starvation25263562
GO:0034599ISS-cellular response to oxidative stress-
GO:0036091IMP-positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress23274085
GO:0042149IMP-cellular response to glucose starvation25263562
GO:0043491IEA-protein kinase B signaling-
GO:0046323IEA-glucose import-
GO:0070328IEA-triglyceride homeostasis-
GO:0071230IMP-cellular response to amino acid stimulus25457612
GO:0071233IMP-cellular response to leucine26586190
GO:0072593IMP-reactive oxygen species metabolic process15105503
GO:0090526IEA-regulation of gluconeogenesis involved in cellular glucose homeostasis-
GO:0098869IDA-cellular oxidant detoxification26612684
GO:0098869IDANOTcellular oxidant detoxification19113821
GO:0098869IMP-cellular oxidant detoxification15105503
GO:1900182IMP-positive regulation of protein localization to nucleus23274085
GO:1901031IEA-regulation of response to reactive oxygen species-
GO:1902010IMP-negative regulation of translation in response to endoplasmic reticulum stress24947615
GO:1904262IMP-negative regulation of TORC1 signaling18692468
GO:1904504IEA-positive regulation of lipophagy-
GO:1990253IMP-cellular response to leucine starvation26449471
GO:2000479IEA-regulation of cAMP-dependent protein kinase activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SESN2PRDX112372415105503 Affinity Capture-Western
SESN2PRDX111108915105503 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2651874
  • Data Attributes: MGI curated and HomoloGene calculated
No data