AutismKB 2.0

Annotation Details for ITCH


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ITCH ( AIF4,AIP4,NAPP1,dJ468O1.1 )
Gene Full Name: itchy E3 ubiquitin protein ligase homolog (mouse)
Band: 20q11.22
Quick LinksEntrez ID:83737; OMIM: 606409; Uniprot ID:ITCH_HUMAN; ENSEMBL ID: ENSG00000078747; HGNC ID: 13890
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane14602072
GO:0005938IEA-cell cortex-
GO:0016020IDA-membrane19946888
GO:0031410IEA-cytoplasmic vesicle-
GO:0070062IDA-extracellular exosome23533145
GO ID Evidence Qualifier GO_term References
GO:0004842IDA-ubiquitin-protein transferase activity17592138
GO:0004842NAS-ubiquitin-protein transferase activity10940313
GO:0005515IPI-protein binding9647693
GO:0016874IEA-ligase activity-
GO:0019787TAS-ubiquitin-like protein transferase activity-
GO:0043021IPI-ribonucleoprotein complex binding19881509
GO:0045236IPI-CXCR chemokine receptor binding19116316
GO:0061630IDA-ubiquitin protein ligase activity15678106
GO:0061630TAS-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0001558NAS-regulation of cell growth9462742
GO:0002669IEA-positive regulation of T cell anergy-
GO:0006511IDA-ubiquitin-dependent protein catabolic process15678106
GO:0006511NAS-ubiquitin-dependent protein catabolic process9462742
GO:0006915IEA-apoptotic process-
GO:0006954NAS-inflammatory response9462742
GO:0007219TAS-Notch signaling pathway-
GO:0016567IDA-protein ubiquitination17592138
GO:0032088ISS-negative regulation of NF-kappaB transcription factor activity-
GO:0032480TAS-negative regulation of type I interferon production-
GO:0035519IDA-protein K29-linked ubiquitination17028573
GO:0042787IEA-protein ubiquitination involved in ubiquitin-dependent protein catabolic process-
GO:0043066IMP-negative regulation of apoptotic process20068034
GO:0045087IEA-innate immune response-
GO:0045732IEA-positive regulation of protein catabolic process-
GO:0046329ISS-negative regulation of JNK cascade-
GO:0046642IEA-negative regulation of alpha-beta T cell proliferation-
GO:0046718TAS-viral entry into host cell12450395
GO:0050687IMP-negative regulation of defense response to virus19881509
GO:0051607IEA-defense response to virus-
GO:0070423TAS-nucleotide-binding oligomerization domain containing signaling pathway-
GO:0070534IDA-protein K63-linked ubiquitination18718448
GO:0070936IDA-protein K48-linked ubiquitination19881509
GO:0090085ISS-regulation of protein deubiquitination-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITCHARR310690017947233 Affinity Capture-Western
ITCHARR312374717947233 Affinity Capture-Western
ITCHARRB110690118544533 Affinity Capture-Western
ITCHARRB112374718544533 Affinity Capture-Western
ITCHARRB212374717947233 18544533 Affinity Capture-Western; Reconstituted Complex
ITCHARRB210690217947233 18544533 Affinity Capture-Western; Reconstituted Complex
ITCHATN11237479647693 Reconstituted Complex; Two-hybrid
ITCHATN11081569647693 Reconstituted Complex; Two-hybrid
ITCHDTX110817318628966 Reconstituted Complex
ITCHDTX112374718628966 Reconstituted Complex
ITCHERBB412374717463226 18334649 Affinity Capture-Western; Far Western; Reconstituted Complex
ITCHERBB410837817463226 18334649 Affinity Capture-Western; Far Western; Reconstituted Complex
ITCHEWSR110843116055720 Affinity Capture-MS
ITCHEWSR112374716055720 Affinity Capture-MS
ITCHMLANA10860415703212 Affinity Capture-Western; Reconstituted Complex
ITCHMLANA12374715703212 Affinity Capture-Western; Reconstituted Complex
ITCHFYN10881016387660 Affinity Capture-Western; Reconstituted Complex
ITCHFYN12374716387660 Affinity Capture-Western; Reconstituted Complex
ITCHSFN10907215778465 Affinity Capture-MS
ITCHSFN12374715778465 Affinity Capture-MS
ITCHHNRNPL10943216055720 Affinity Capture-MS
ITCHHNRNPL12374716055720 Affinity Capture-MS
ITCHJUN10992816901904 Reconstituted Complex
ITCHJUN12374716901904 Reconstituted Complex
ITCHSMAD311026315051726 Reconstituted Complex
ITCHSMAD312374715051726 Reconstituted Complex
ITCHSMAD711026715946939 Affinity Capture-Western
ITCHSMAD712374715946939 Affinity Capture-Western
ITCHNEDD911081615051726 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ITCHNEDD912374715051726 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ITCHNFE211085018718448 Affinity Capture-Western; Biochemical Activity
ITCHNFE212374718718448 Affinity Capture-Western; Biochemical Activity
ITCHPOLR2A11142616055720 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
ITCHPOLR2A12374716055720 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
ITCHPOLR2B12374716055720 Affinity Capture-MS
ITCHPOLR2B11142716055720 Affinity Capture-MS
ITCHPOLR2C12374716055720 Affinity Capture-MS
ITCHPOLR2C11142816055720 Affinity Capture-MS
ITCHPOLR2E12374716055720 Affinity Capture-MS
ITCHPOLR2E11143016055720 Affinity Capture-MS
ITCHSCNN1A11224111244092 Far Western
ITCHSCNN1A12374711244092 Far Western
ITCHSCNN1B11224211244092 Far Western
ITCHSCNN1B12374711244092 Far Western
ITCHSH3GL211235314684745 Affinity Capture-Western
ITCHSH3GL212374714684745 Affinity Capture-Western
ITCHSMARCC112374716055720 Affinity Capture-MS
ITCHSMARCC111248316055720 Affinity Capture-MS
ITCHSMARCC212374716055720 Affinity Capture-MS
ITCHSMARCC211248516055720 Affinity Capture-MS
ITCHSMARCE111248916055720 Affinity Capture-MS
ITCHSMARCE112374716055720 Affinity Capture-MS
ITCHTP5312374718559494 Affinity Capture-Western
ITCHTP5311301018559494 Affinity Capture-Western
ITCHTP7311301415678106 17110958 17592138 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
ITCHTP7312374715678106 17110958 17592138 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
ITCHUBC11316417038327 17719543 Affinity Capture-Western; Reconstituted Complex
ITCHUBC12374717038327 17719543 Affinity Capture-Western; Reconstituted Complex
ITCHUBE2L312374717719543 Reconstituted Complex
ITCHUBE2L311318017719543 Reconstituted Complex
ITCHSF111336816055720 Affinity Capture-MS
ITCHSF112374716055720 Affinity Capture-MS
ITCHCXCR411360719116316 Affinity Capture-Western; FRET; Reconstituted Complex
ITCHCXCR412374719116316 Affinity Capture-Western; FRET; Reconstituted Complex
ITCHUSP9X11386717038327 Affinity Capture-Western; Reconstituted Complex
ITCHUSP9X12374717038327 Affinity Capture-Western; Reconstituted Complex
ITCHARID1A11389416055720 Affinity Capture-MS
ITCHARID1A12374716055720 Affinity Capture-MS
ITCHNUMB11420212682059 18628966 Affinity Capture-Western; Reconstituted Complex
ITCHNUMB12374712682059 18628966 Affinity Capture-Western; Reconstituted Complex
ITCHC19orf211426416055720 Affinity Capture-MS
ITCHC19orf212374716055720 Affinity Capture-MS
ITCHRIPK111427419131965 Affinity Capture-Western
ITCHRIPK112374719131965 Affinity Capture-Western
ITCHCFLAR11436418559494 Affinity Capture-Western
ITCHCFLAR12374718559494 Affinity Capture-Western
ITCHUSP1312374719615732 Affinity Capture-MS
ITCHUSP1311446519615732 Affinity Capture-MS
ITCHHGS11459314602072 Affinity Capture-Western
ITCHHGS12374714602072 Affinity Capture-Western
ITCHN4BP111503617592138 Affinity Capture-Western; Reconstituted Complex
ITCHN4BP112374717592138 Affinity Capture-Western; Reconstituted Complex
ITCHUBAP2L12374716055720 Affinity Capture-MS; Reconstituted Complex
ITCHUBAP2L11522716055720 Affinity Capture-MS; Reconstituted Complex
ITCHYAP112374717110958 Affinity Capture-Western
ITCHYAP111568417110958 Affinity Capture-Western
ITCHNUDT2112374716055720 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
ITCHNUDT2111623716055720 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
ITCHCPSF612374716055720 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
ITCHCPSF611623816055720 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
ITCHHNRNPUL111628116055720 Affinity Capture-MS
ITCHHNRNPUL112374716055720 Affinity Capture-MS
ITCHSPG2011673416055720 Affinity Capture-MS
ITCHSPG2012374716055720 Affinity Capture-MS
ITCHWBP212374716055720 Affinity Capture-MS
ITCHWBP211710216055720 Affinity Capture-MS
ITCHCBLC11715612226085 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ITCHCBLC12374712226085 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ITCHDAZAP112374716055720 Affinity Capture-MS
ITCHDAZAP111773016055720 Affinity Capture-MS
ITCHPABPC111793916055720 Affinity Capture-MS
ITCHPABPC112374716055720 Affinity Capture-MS
ITCHRNF1111794119131965 Affinity Capture-Western
ITCHRNF1112374719131965 Affinity Capture-Western
ITCHUBAP212093816055720 Affinity Capture-MS
ITCHUBAP212374716055720 Affinity Capture-MS
ITCHRPAP312374716055720 Affinity Capture-MS
ITCHRPAP312278316055720 Affinity Capture-MS
ITCHCPSF712295716055720 Affinity Capture-MS
ITCHCPSF712374716055720 Affinity Capture-MS
ITCHRPAP212374716055720 Affinity Capture-MS
ITCHRPAP212295916055720 Affinity Capture-MS
ITCHITCH12374716055720 17038327 17592138 18718449 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
Gene Symbol Interactant Interaction ID References Description
ITCHATN12090249647693 Atrophin-1 interacts with AIP4.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1202301
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved