AutismKB 2.0

Annotation Details for PPP1R1B


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Basic Information Top
Gene Symbol:PPP1R1B ( DARPP-32,DARPP32,FLJ20940 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 1B
Band: 17q12
Quick LinksEntrez ID:84152; OMIM: 604399; Uniprot ID:PPR1B_HUMAN; ENSEMBL ID: ENSG00000131771; HGNC ID: 9287
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005737IBA-cytoplasm-
GO:0005829TAS-cytosol-
GO:0043025IEA-neuronal cell body-
GO ID Evidence Qualifier GO_term References
GO:0004860TAS-protein kinase inhibitor activity10604473
GO:0004862TAS-cAMP-dependent protein kinase inhibitor activity-
GO:0004864IDA-protein phosphatase inhibitor activity10807923
GO:0004864TAS-protein phosphatase inhibitor activity10604473
GO:0004865IBA-protein serine/threonine phosphatase inhibitor activity-
GO:0005515IPI-protein binding25416956
GO:0019888TAS-protein phosphatase regulator activity-
GO:0031748IEA-D1 dopamine receptor binding-
GO:0031749IEA-D2 dopamine receptor binding-
GO:0031750IEA-D3 dopamine receptor binding-
GO:0031751IEA-D4 dopamine receptor binding-
GO:0031752IEA-D5 dopamine receptor binding-
GO ID Evidence Qualifier GO_term References
GO:0001975IEA-response to amphetamine-
GO:0006351IEA-transcription, DNA-templated-
GO:0007165TAS-signal transduction10604473
GO:0007621IEA-negative regulation of female receptivity-
GO:0008542IEA-visual learning-
GO:0032515IDA-negative regulation of phosphoprotein phosphatase activity10807923
GO:0035556IBA-intracellular signal transduction-
GO:0071901IEA-negative regulation of protein serine/threonine kinase activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PPP1R1BDLGAP412391516169070 Two-hybrid
PPP1R1BDLGAP411651316169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
PPP1R1BIVS2+31G/A, IVS6+32A/G, PPP1R1B_1238delG, PPP1R1B_2036C/G, PPP1R1B_E135del, PPP1R1B_M01, PPP1R1B_M02, PPP1R1B_M05, PPP1R1B_M06, PPP1R1B_M07, PPP1R1B_M09, PPP1R1B_M10, PPP1R1B_M16, rs11651497, rs12601930, rs1495099, rs2271309, rs3764352, rs3764353, rs3794712, rs3817160, rs4795390, rs734645, rs879606, rs907094 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:94860
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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