AutismKB 2.0

Annotation Details for RNF135


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Basic Information Top
Gene Symbol:RNF135 ( MGC13061,REUL,Riplet )
Gene Full Name: ring finger protein 135
Band: 17q11.2
Quick LinksEntrez ID:84282; OMIM: 611358; Uniprot ID:RN135_HUMAN; ENSEMBL ID: ENSG00000181481; HGNC ID: 21158
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm19484123
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0004842EXP-ubiquitin-protein transferase activity17392790
GO:0004842IDA-ubiquitin-protein transferase activity19484123
GO:0005515IPI-protein binding19017631
GO:0042802IPI-identical protein binding25416956
GO:0043021IPI-ribonucleoprotein complex binding19881509
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0016567IDA-protein ubiquitination19017631
GO:0016567IEA-protein ubiquitination-
GO:0016579TAS-protein deubiquitination-
GO:0032480TAS-negative regulation of type I interferon production-
GO:0032728IMP-positive regulation of interferon-beta production19017631
GO:0045087TAS-innate immune response-
GO:0045088IMP-regulation of innate immune response19017631
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RNF135RARRES312400919017631 Affinity Capture-Western; Biochemical Activity; Two-hybrid
RNF135RARRES311185519017631 Affinity Capture-Western; Biochemical Activity; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1919206
  • Data Attributes: HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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