AutismKB 2.0

Annotation Details for NCK2


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Basic Information Top
Gene Symbol:NCK2 ( GRB4,NCKbeta )
Gene Full Name: NCK adaptor protein 2
Band: 2q12.2
Quick LinksEntrez ID:8440; OMIM: 604930; Uniprot ID:NCK2_HUMAN; ENSEMBL ID: ENSG00000071051; HGNC ID: 7665
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm25468996
GO:0005737NAS-cytoplasm12110186
GO:0005783IDA-endoplasmic reticulum16835242
GO:0005829TAS-cytosol-
GO:0012506IEA-vesicle membrane-
GO:0014069IEA-postsynaptic density-
GO ID Evidence Qualifier GO_term References
GO:0001784IPI-phosphotyrosine residue binding20624904
GO:0005070NAS-SH3/SH2 adaptor activity16835242
GO:0005515IPI-protein binding10026169
GO:0008093NAS-cytoskeletal adaptor activity12110186
GO:0030159NAS-receptor signaling complex scaffold activity12110186
GO:0032403IEA-protein complex binding-
GO:0097110IEA-scaffold protein binding-
GO ID Evidence Qualifier GO_term References
GO:0001771IEA-immunological synapse formation-
GO:0007015IEA-actin filament organization-
GO:0007165TAS-signal transduction9737977
GO:0007172NAS-signal complex assembly12110186
GO:0007173TAS-epidermal growth factor receptor signaling pathway9737977
GO:0007176TAS-regulation of epidermal growth factor-activated receptor activity9737977
GO:0008285TAS-negative regulation of cell proliferation9737977
GO:0016477IEA-cell migration-
GO:0030032IEA-lamellipodium assembly-
GO:0030838IMP-positive regulation of actin filament polymerization12110186
GO:0033137IDA-negative regulation of peptidyl-serine phosphorylation16835242
GO:0036493IEA-positive regulation of translation in response to endoplasmic reticulum stress-
GO:0042102IMP-positive regulation of T cell proliferation12110186
GO:0042110NAS-T cell activation12110186
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter10026169
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0060996IEA-dendritic spine development-
GO:1902237IEA-positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-
GO:1903898IEA-negative regulation of PERK-mediated unfolded protein response-
GO:1903912IDA-negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation16835242
GO:1990441IEA-negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NCK2CBLB11402016189514 Two-hybrid
NCK2CBLB10731616189514 Two-hybrid
NCK2CD3E11402012110186 Reconstituted Complex; Two-hybrid
NCK2CD3E10735412110186 Reconstituted Complex; Two-hybrid
NCK2DOCK111402011240126 Reconstituted Complex
NCK2DOCK110812811240126 Reconstituted Complex
NCK2DOK11140209737977 Reconstituted Complex
NCK2DOK11081319737977 Reconstituted Complex
NCK2EEF1G11402016169070 Two-hybrid
NCK2EEF1G10825716169070 Two-hybrid
NCK2EGFR1082769737977 9843575 10026169 Affinity Capture-Western; Reconstituted Complex
NCK2EGFR1140209737977 9843575 10026169 Affinity Capture-Western; Reconstituted Complex
NCK2HNRNPK11402016189514 Two-hybrid
NCK2HNRNPK10943116189514 Two-hybrid
NCK2ILK10982410022929 Reconstituted Complex
NCK2ILK11402010022929 Reconstituted Complex
NCK2IRS11140209843575 Reconstituted Complex
NCK2IRS11098749843575 Reconstituted Complex
NCK2LIMS11140209843575 10022929 Reconstituted Complex; Two-hybrid
NCK2LIMS11101759843575 10022929 Reconstituted Complex; Two-hybrid
NCK2NTRK211402012074588 Reconstituted Complex; Two-hybrid
NCK2NTRK211097012074588 Reconstituted Complex; Two-hybrid
NCK2PAK111109510026169 Affinity Capture-Western
NCK2PAK111402010026169 Affinity Capture-Western
NCK2PDGFRB1111859737977 10026169 11027258 Affinity Capture-Western; Reconstituted Complex
NCK2PDGFRB1140209737977 10026169 11027258 Affinity Capture-Western; Reconstituted Complex
NCK2PKN211402010026169 Affinity Capture-Western
NCK2PKN211157210026169 Affinity Capture-Western
NCK2PTK211402011950595 Affinity Capture-Western; Reconstituted Complex
NCK2PTK211171911950595 Affinity Capture-Western; Reconstituted Complex
NCK2SOS111253710026169 Affinity Capture-Western
NCK2SOS111402010026169 Affinity Capture-Western
NCK2TRIP611402016189514 Two-hybrid
NCK2TRIP611305616189514 Two-hybrid
WIPF2NCK211402012213210 Affinity Capture-Western
WIPF2NCK212704312213210 Affinity Capture-Western
ABI2NCK211402016189514 Two-hybrid
ABI2NCK211545416189514 Two-hybrid
SF3B4NCK211402016189514 Two-hybrid
SF3B4NCK211555416189514 Two-hybrid
CPSF6NCK211402016189514 Two-hybrid
CPSF6NCK211623816189514 Two-hybrid
NCKIPSDNCK211402016189514 Two-hybrid
NCKIPSDNCK211958316189514 Two-hybrid
WBP11NCK211402016189514 Two-hybrid
WBP11NCK211970216189514 Two-hybrid
KIAA1217NCK211402016189514 Two-hybrid
KIAA1217NCK212111116189514 Two-hybrid
CPSF7NCK211402016189514 Two-hybrid
CPSF7NCK212295716189514 Two-hybrid
FXR2NCK211489016189514 Two-hybrid
FXR2NCK211402016189514 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
NCK2FGFR125964815117958 An unspecified isoform of FGFR1 interacts with NCK2. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human NCK2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1306821
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-686'