AutismKB 2.0

Annotation Details for CUL3


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Basic Information Top
Gene Symbol:CUL3 ( - )
Gene Full Name: cullin 3
Band: 2q36.2
Quick LinksEntrez ID:8452; OMIM: 603136; Uniprot ID:CUL3_HUMAN; ENSEMBL ID: ENSG00000036257; HGNC ID: 2553
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005654TAS-nucleoplasm-
GO:0005827IDA-polar microtubule19995937
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane19946888
GO:0031463IDA-Cul3-RING ubiquitin ligase complex15983046
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0004842IDAcontributes_toubiquitin-protein transferase activity15983046
GO:0005112IPI-Notch binding25401743
GO:0005515IPI-protein binding12609982
GO:0030332IEA-cyclin binding-
GO:0031208IDA-POZ domain binding19261606
GO:0031625IBA-ubiquitin protein ligase binding-
GO:0042803IEA-protein homodimerization activity-
GO:0046982IEA-protein heterodimerization activity-
GO:0061630IBAcontributes_toubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0000082TAS-G1/S transition of mitotic cell cycle8681378
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0000165TAS-MAPK cascade-
GO:0000209IDA-protein polyubiquitination19261606
GO:0001831IEA-trophectodermal cellular morphogenesis-
GO:0006511IDA-ubiquitin-dependent protein catabolic process25401743
GO:0006513IDA-protein monoubiquitination22358839
GO:0006888IDA-ER to Golgi vesicle-mediated transport22358839
GO:0007050TAS-cell cycle arrest8681378
GO:0007080IMP-mitotic metaphase plate congression17543862
GO:0007229ISS-integrin-mediated signaling pathway-
GO:0007369IEA-gastrulation-
GO:0008284TAS-positive regulation of cell proliferation9733711
GO:0016055IEA-Wnt signaling pathway-
GO:0016477IMP-cell migration19782033
GO:0016567IDA-protein ubiquitination17543862
GO:0017145ISS-stem cell division-
GO:0030030IEA-cell projection organization-
GO:0031145IDA-anaphase-promoting complex-dependent catabolic process10500095
GO:0032467IMP-positive regulation of cytokinesis19261606
GO:0035024IMP-negative regulation of Rho protein signal transduction19782033
GO:0040016ISS-embryonic cleavage-
GO:0042787IDA-protein ubiquitination involved in ubiquitin-dependent protein catabolic process27561354
GO:0043149IMP-stress fiber assembly19782033
GO:0043161IDA-proteasome-mediated ubiquitin-dependent protein catabolic process19261606
GO:0043687TAS-post-translational protein modification-
GO:0044346IEA-fibroblast apoptotic process-
GO:0045842IMP-positive regulation of mitotic metaphase/anaphase transition17543862
GO:0048208IMP-COPII vesicle coating22358839
GO:0071630IDA-ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome27561354
GO:0072576IEA-liver morphogenesis-
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway-
GO:0097193TAS-intrinsic apoptotic signaling pathway8681378
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CUL3ARHGDIB10689018303015 Affinity Capture-Western
CUL3ARHGDIB11403018303015 Affinity Capture-Western
CUL3BMI111403015897469 Affinity Capture-Western
CUL3BMI110711615897469 Affinity Capture-Western
CUL3CCNE111403010500095 17192413 Affinity Capture-Western; Two-hybrid
CUL3CCNE110733810500095 17192413 Affinity Capture-Western; Two-hybrid
CUL3DNTT10812718429817 Affinity Capture-Western
CUL3DNTT11403018429817 Affinity Capture-Western
CUL3NEDD811081516620772 17192413 Affinity Capture-MS; Affinity Capture-Western
CUL3NEDD811403016620772 17192413 Affinity Capture-MS; Affinity Capture-Western
CUL3NFE2L211403015367669 15601839 Affinity Capture-Western
CUL3NFE2L211085215367669 15601839 Affinity Capture-Western
CUL3PMS111403017148452 Affinity Capture-Western
CUL3PMS111139117148452 Affinity Capture-Western
CUL3SUMO311249616620772 Affinity Capture-MS
CUL3SUMO311403016620772 Affinity Capture-MS
CUL3SUMO211403016620772 Affinity Capture-MS
CUL3SUMO211249716620772 Affinity Capture-MS
CUL3GAN11380015983046 Affinity Capture-Western
CUL3GAN11403015983046 Affinity Capture-Western
RBX1CUL311530111861641 12481031 15448697 15601839 Affinity Capture-MS; Affinity Capture-Western
RBX1CUL311403011861641 12481031 15448697 15601839 Affinity Capture-MS; Affinity Capture-Western
CAND1CUL312093712609982 Affinity Capture-MS; Affinity Capture-Western
CAND1CUL311403012609982 Affinity Capture-MS; Affinity Capture-Western
KEAP1CUL311515615282312 15367669 15572695 15601839 15983046 17439941 17822677 18251510 18417180 Affinity Capture-Western; Reconstituted Complex
KEAP1CUL311403015282312 15367669 15572695 15601839 15983046 17439941 17822677 18251510 18417180 Affinity Capture-Western; Reconstituted Complex
H2AFYCUL311492715897469 Affinity Capture-Western
H2AFYCUL311403015897469 Affinity Capture-Western
KBTBD10CUL311560715983046 Affinity Capture-Western
KBTBD10CUL311403015983046 Affinity Capture-Western
ENC1CUL311407915983046 Affinity Capture-Western
ENC1CUL311403015983046 Affinity Capture-Western
COPS3CUL311410316036220 Affinity Capture-MS
COPS3CUL311403016036220 Affinity Capture-MS
KLHL12CUL312189016547521 18303015 Affinity Capture-Western
KLHL12CUL311403016547521 18303015 Affinity Capture-Western
PGAM5CUL312815417046835 Affinity Capture-Western
PGAM5CUL311403017046835 Affinity Capture-Western
CUL3CUL311403017192413 Affinity Capture-Western; FRET
ABTB2CUL311736718429817 Affinity Capture-Western; Reconstituted Complex
ABTB2CUL311403018429817 Affinity Capture-Western; Reconstituted Complex
KCTD5CUL311995818573101 Affinity Capture-Western; Reconstituted Complex
KCTD5CUL311403018573101 Affinity Capture-Western; Reconstituted Complex
DCUN1D1CUL311992018826954 Affinity Capture-Western; Reconstituted Complex
DCUN1D1CUL311403018826954 Affinity Capture-Western; Reconstituted Complex
COPS6CUL311617619615732 Affinity Capture-MS
COPS6CUL311403019615732 Affinity Capture-MS
COPS5CUL311618319615732 Affinity Capture-MS
COPS5CUL311403019615732 Affinity Capture-MS
KCTD11CUL311403020081843 Affinity Capture-Western; Biochemical Activity
KCTD11CUL312703120081843 Affinity Capture-Western; Biochemical Activity
GABARAPL2CUL311647320562859 Affinity Capture-MS
GABARAPL2CUL311403020562859 Affinity Capture-MS
GABARAPL1CUL311722320562859 Affinity Capture-MS
GABARAPL1CUL311403020562859 Affinity Capture-MS
KBTBD7CUL312387320562859 Affinity Capture-MS
KBTBD7CUL311403020562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1347360
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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