AutismKB 2.0

Annotation Details for CUL2


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Basic Information Top
Gene Symbol:CUL2 ( MGC131970 )
Gene Full Name: cullin 2
Band: 10p11.21
Quick LinksEntrez ID:8453; OMIM: 603135; Uniprot ID:CUL2_HUMAN; ENSEMBL ID: ENSG00000108094; HGNC ID: 2552
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005730IEA-nucleolus-
GO:0005829TAS-cytosol-
GO:0030891IEA-VCB complex-
GO:0031462IDA-Cul2-RING ubiquitin ligase complex17636018
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding12504026
GO:0031625IDA-ubiquitin protein ligase binding17636018
GO:0032403IEA-protein complex binding-
GO:0061630IBAcontributes_toubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0000082TAS-G1/S transition of mitotic cell cycle8681378
GO:0007050TAS-cell cycle arrest8681378
GO:0008285TAS-negative regulation of cell proliferation8681378
GO:0016032IEA-viral process-
GO:0016567TAS-protein ubiquitination-
GO:0042787IBA-protein ubiquitination involved in ubiquitin-dependent protein catabolic process-
GO:0043687TAS-post-translational protein modification-
GO:0061418TAS-regulation of transcription from RNA polymerase II promoter in response to hypoxia-
GO:0097193TAS-intrinsic apoptotic signaling pathway8681378
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CUL2DLG310808517353931 Affinity Capture-MS
CUL2DLG311403117353931 Affinity Capture-MS
CUL2STOM10835417353931 Affinity Capture-MS
CUL2STOM11403117353931 Affinity Capture-MS
CUL2HIF1A10933817439941 Affinity Capture-Western
CUL2HIF1A11403117439941 Affinity Capture-Western
CUL2NEDD811081516620772 18173839 Affinity Capture-MS; Reconstituted Complex
CUL2NEDD811403116620772 18173839 Affinity Capture-MS; Reconstituted Complex
CUL2P4HB11107317353931 Affinity Capture-MS
CUL2P4HB11403117353931 Affinity Capture-MS
CUL2PFKFB311123017353931 Affinity Capture-MS
CUL2PFKFB311403117353931 Affinity Capture-MS
CUL2TCEB111278311384984 15966899 17183367 Affinity Capture-Western; Reconstituted Complex
CUL2TCEB111403111384984 15966899 17183367 Affinity Capture-Western; Reconstituted Complex
CUL2TCEB211403111384984 12048197 15966899 18173839 Affinity Capture-Western; Reconstituted Complex
CUL2TCEB211278511384984 12048197 15966899 18173839 Affinity Capture-Western; Reconstituted Complex
CUL2TFE311288817353931 Affinity Capture-MS
CUL2TFE311403117353931 Affinity Capture-MS
CUL2VHL11403110587522 11384984 11865071 12048197 12604794 15966899 16611863 17353931 17439941 18173839 19030229 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CUL2VHL11326910587522 11384984 11865071 12048197 12604794 15966899 16611863 17353931 17439941 18173839 19030229 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CUL2ARID1A11403120086098 Affinity Capture-Western
CUL2ARID1A11389420086098 Affinity Capture-Western
RBX1CUL211530110230407 11861641 12481031 15448697 17183367 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RBX1CUL211403110230407 11861641 12481031 15448697 17183367 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RNF7CUL211497710230407 Two-hybrid
RNF7CUL211403110230407 Two-hybrid
COPS2CUL211403111967155 Affinity Capture-Western
COPS2CUL211472911967155 Affinity Capture-Western
CAND1CUL211403112609982 18173839 Affinity Capture-MS; Affinity Capture-Western
CAND1CUL212093712609982 18173839 Affinity Capture-MS; Affinity Capture-Western
KEAP1CUL211403115572695 Affinity Capture-Western
KEAP1CUL211515615572695 Affinity Capture-Western
COPS3CUL211403116036220 Affinity Capture-MS
COPS3CUL211410316036220 Affinity Capture-MS
COMMD1CUL211403117183367 Affinity Capture-Western; Reconstituted Complex
COMMD1CUL212731717183367 Affinity Capture-Western; Reconstituted Complex
CMBLCUL211403117353931 Affinity Capture-MS
CMBLCUL212638717353931 Affinity Capture-MS
TIMM13CUL211403117353931 Affinity Capture-MS
TIMM13CUL211772217353931 Affinity Capture-MS
RPL35P5CUL213729717353931 Affinity Capture-MS
RPL35P5CUL211403117353931 Affinity Capture-MS
CAB39CUL211969617353931 Affinity Capture-MS
CAB39CUL211403117353931 Affinity Capture-MS
KCTD5CUL211403117353931 Affinity Capture-MS
KCTD5CUL211995817353931 Affinity Capture-MS
RNMTL1CUL211403117353931 Affinity Capture-MS
RNMTL1CUL212047717353931 Affinity Capture-MS
ASB4CUL211403117636018 Affinity Capture-Western
ASB4CUL211966917636018 Affinity Capture-Western
SAP130CUL211403118173839 Affinity Capture-Western; Reconstituted Complex
SAP130CUL212273518173839 Affinity Capture-Western; Reconstituted Complex
DCUN1D1CUL211403118826954 Affinity Capture-Western; Reconstituted Complex
DCUN1D1CUL211992018826954 Affinity Capture-Western; Reconstituted Complex
COPS6CUL211403119615732 Affinity Capture-MS
COPS6CUL211617619615732 Affinity Capture-MS
COPS5CUL211403119615732 Affinity Capture-MS
COPS5CUL211618319615732 Affinity Capture-MS
TCEAL1CUL211474519615732 Affinity Capture-MS
TCEAL1CUL211403119615732 Affinity Capture-MS
ARID1BCUL211403120086098 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
ARID1BCUL212155920086098 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
KLHDC10CUL211403120562859 Affinity Capture-MS
KLHDC10CUL211665220562859 Affinity Capture-MS
SH3GLB1CUL211403120562859 Affinity Capture-MS
SH3GLB1CUL211928920562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1918995
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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