AutismKB 2.0

Annotation Details for CUL1


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Basic Information Top
Gene Symbol:CUL1 ( MGC149834,MGC149835 )
Gene Full Name: cullin 1
Band: 7q36.1
Quick LinksEntrez ID:8454; OMIM: 603134; Uniprot ID:CUL1_HUMAN; ENSEMBL ID: ENSG00000055130; HGNC ID: 2551
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654TAS-nucleoplasm-
GO:0005829TAS-cytosol-
GO:0019005IDA-SCF ubiquitin ligase complex11956208
GO:0019005ISS-SCF ubiquitin ligase complex-
GO:0031461IDA-cullin-RING ubiquitin ligase complex22405651
GO:1990452IPI-Parkin-FBXW7-Cul1 ubiquitin ligase complex12628165
GO ID Evidence Qualifier GO_term References
GO:0004842EXP-ubiquitin-protein transferase activity11158290
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding11961546
GO:0031625IBA-ubiquitin protein ligase binding-
GO:0061630IBAcontributes_toubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0000082TAS-G1/S transition of mitotic cell cycle8681378
GO:0000086TAS-G2/M transition of mitotic cell cycle-
GO:0000209TAS-protein polyubiquitination-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0006513IEA-protein monoubiquitination-
GO:0006879TAS-cellular iron ion homeostasis-
GO:0007050TAS-cell cycle arrest8681378
GO:0008283IEA-cell proliferation-
GO:0008285TAS-negative regulation of cell proliferation8681378
GO:0009887IEA-animal organ morphogenesis-
GO:0010265TAS-SCF complex assembly-
GO:0010972TAS-negative regulation of G2/M transition of mitotic cell cycle-
GO:0016032IEA-viral process-
GO:0016055TAS-Wnt signaling pathway-
GO:0016567IDA-protein ubiquitination15103331
GO:0031146IDA-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process15103331
GO:0031146ISS-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-
GO:0031146TAS-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-
GO:0038061TAS-NIK/NF-kappaB signaling-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0042787IBA-protein ubiquitination involved in ubiquitin-dependent protein catabolic process-
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0043687TAS-post-translational protein modification-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051403TAS-stress-activated MAPK cascade-
GO:0051437TAS-positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition-
GO:0097193TAS-intrinsic apoptotic signaling pathway8681378
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CUL1CDC25A11403214681206 Affinity Capture-Western
CUL1CDC25A10742814681206 Affinity Capture-Western
CUL1CDC3411403216123592 Reconstituted Complex
CUL1CDC3410743216123592 Reconstituted Complex
CUL1CDK911403211689688 Affinity Capture-Western
CUL1CDK910745911689688 Affinity Capture-Western
CUL1CDKN1C11403212925736 Biochemical Activity
CUL1CDKN1C10746212925736 Biochemical Activity
CUL1CHUK11403217914462 Affinity Capture-Western
CUL1CHUK10756917914462 Affinity Capture-Western
CUL1E2F110820110559858 Affinity Capture-Western; Reconstituted Complex
CUL1E2F111403210559858 Affinity Capture-Western; Reconstituted Complex
CUL1GPS111403216036220 Affinity Capture-Western
CUL1GPS110913116036220 Affinity Capture-Western
CUL1SMAD311403215798217 Affinity Capture-Western
CUL1SMAD311026315798217 Affinity Capture-Western
CUL1MYC11403212769844 Affinity Capture-Western
CUL1MYC11069412769844 Affinity Capture-Western
CUL1NEDD811403216177058 16620772 18627766 Affinity Capture-MS; Affinity Capture-Western
CUL1NEDD811081516177058 16620772 18627766 Affinity Capture-MS; Affinity Capture-Western
CUL1NFKBIA11403211483504 Affinity Capture-Western
CUL1NFKBIA11085911483504 Affinity Capture-Western
CUL1PARK211110512628165 Affinity Capture-Western; Reconstituted Complex
CUL1PARK211403212628165 Affinity Capture-Western; Reconstituted Complex
CUL1PMS111403217148452 Affinity Capture-Western
CUL1PMS111139117148452 Affinity Capture-Western
CUL1PSMA211165616759355 Affinity Capture-Western
CUL1PSMA211403216759355 Affinity Capture-Western
CUL1PSMA411165816759355 Affinity Capture-Western
CUL1PSMA411403216759355 Affinity Capture-Western
CUL1PSMA611166016759355 Affinity Capture-Western; Reconstituted Complex
CUL1PSMA611403216759355 Affinity Capture-Western; Reconstituted Complex
CUL1PSMA711166116759355 Reconstituted Complex
CUL1PSMA711403216759355 Reconstituted Complex
CUL1PSMD411403216759355 Reconstituted Complex
CUL1PSMD411168316759355 Reconstituted Complex
CUL1PTGS211403217429597 Affinity Capture-Western
CUL1PTGS211171517429597 Affinity Capture-Western
CUL1RAC211403211445862 Two-hybrid
CUL1RAC211181811445862 Two-hybrid
CUL1RBL211403212717421 Affinity Capture-Western
CUL1RBL211186912717421 Affinity Capture-Western
CUL1SKP11140329430629 10230407 11961546 12609982 12628165 15452136 15966899 16357137 16759355 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
CUL1SKP11123919430629 10230407 11961546 12609982 12628165 15452136 15966899 16357137 16759355 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
CUL1SKP21140329430629 10559858 11961546 12609982 12840033 16774918 16880511 17439941 18173839 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
CUL1SKP21123939430629 10559858 11961546 12609982 12840033 16774918 16880511 17439941 18173839 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
CUL1SNRNP7011403211850407 Affinity Capture-Western
CUL1SNRNP7011250911850407 Affinity Capture-Western
CUL1TRIM2111403216880511 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
CUL1TRIM2111261516880511 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
CUL1UBC11316416759355 Affinity Capture-Western
CUL1UBC11403216759355 Affinity Capture-Western
RBX1CUL111403210230407 11483504 11861641 11956208 11961546 12481031 12609982 12706828 15448697 16123592 16759355 18826954 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Two-hybrid
RBX1CUL111530110230407 11483504 11861641 11956208 11961546 12481031 12609982 12706828 15448697 16123592 16759355 18826954 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Two-hybrid
RNF7CUL111403210230407 11483504 Affinity Capture-Western; Two-hybrid
RNF7CUL111497710230407 11483504 Affinity Capture-Western; Two-hybrid
FBXO4CUL111403210531035 17353931 Affinity Capture-MS; Affinity Capture-Western
FBXO4CUL111765610531035 17353931 Affinity Capture-MS; Affinity Capture-Western
BTRCCUL111403210531035 10644755 11483504 11850407 12609982 15966899 19615732 Affinity Capture-MS; Affinity Capture-Western
BTRCCUL111445710531035 10644755 11483504 11850407 12609982 15966899 19615732 Affinity Capture-MS; Affinity Capture-Western
FBXO7CUL111403210531035 15145941 18495667 Affinity Capture-Western
FBXO7CUL111732610531035 15145941 18495667 Affinity Capture-Western
FBXW2CUL111403210531035 Affinity Capture-Western
FBXW2CUL111760310531035 Affinity Capture-Western
FBXL3CUL111403210531035 Affinity Capture-Western
FBXL3CUL111761510531035 Affinity Capture-Western
FBXW11CUL111403210644755 19615732 Affinity Capture-MS; Affinity Capture-Western
FBXW11CUL111688710644755 19615732 Affinity Capture-MS; Affinity Capture-Western
FBXW7CUL111403211585921 Reconstituted Complex
FBXW7CUL112058111585921 Reconstituted Complex
FBXO18CUL111403211956208 15118074 Affinity Capture-Western; Reconstituted Complex
FBXO18CUL112433311956208 15118074 Affinity Capture-Western; Reconstituted Complex
COPS2CUL111403211967155 16036220 Affinity Capture-Western
COPS2CUL111472911967155 16036220 Affinity Capture-Western
CAND1CUL111403212609982 12706828 16036220 17439941 18173839 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CAND1CUL112093712609982 12706828 16036220 17439941 18173839 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CDCA3CUL111403212679038 Affinity Capture-Western
CDCA3CUL112365712679038 Affinity Capture-Western
CDT1CUL111403212840033 Affinity Capture-Western
CDT1CUL112355512840033 Affinity Capture-Western
TBK1CUL111403214743216 Affinity Capture-MS
TBK1CUL111887814743216 Affinity Capture-MS
KEAP1CUL111403215572695 Affinity Capture-Western
KEAP1CUL111515615572695 Affinity Capture-Western
GCM1CUL111409315640526 Affinity Capture-Western
GCM1CUL111403215640526 Affinity Capture-Western
ZC3HC1CUL111403216009132 17389604 Affinity Capture-Western; Reconstituted Complex
ZC3HC1CUL111959216009132 17389604 Affinity Capture-Western; Reconstituted Complex
COPS3CUL111403216036220 Affinity Capture-MS
COPS3CUL111410316036220 Affinity Capture-MS
COPS5CUL111403216036220 19615732 Affinity Capture-MS; Affinity Capture-Western
COPS5CUL111618316036220 19615732 Affinity Capture-MS; Affinity Capture-Western
COPS4CUL111403216036220 Affinity Capture-Western
COPS4CUL111932416036220 Affinity Capture-Western
FBXO31CUL111403216357137 Affinity Capture-Western
FBXO31CUL112289016357137 Affinity Capture-Western
FBXO11CUL111403217098746 Affinity Capture-Western
FBXO11CUL112317317098746 Affinity Capture-Western
RPRMCUL111403217353931 Affinity Capture-MS
RPRMCUL112114517353931 Affinity Capture-MS
COPS8CUL111403218173839 Affinity Capture-Western
COPS8CUL111612418173839 Affinity Capture-Western
SAP130CUL111403218173839 Affinity Capture-Western
SAP130CUL112273518173839 Affinity Capture-Western
C13orf34CUL111403218378770 Affinity Capture-Western
C13orf34CUL112295418378770 Affinity Capture-Western
HIPK2CUL111403218765672 Affinity Capture-Western
HIPK2CUL111881518765672 Affinity Capture-Western
NLKCUL111403218765672 Affinity Capture-Western
NLKCUL111968518765672 Affinity Capture-Western
DCUN1D1CUL111403218826954 Affinity Capture-Western; Reconstituted Complex
DCUN1D1CUL111992018826954 Affinity Capture-Western; Reconstituted Complex
C20orf94CUL111403219596235 Affinity Capture-MS
C20orf94CUL112614719596235 Affinity Capture-MS
SLX1BCUL111403219596235 Affinity Capture-MS
SLX1BCUL112247919596235 Affinity Capture-MS
COPS6CUL111403219615732 Affinity Capture-MS
COPS6CUL111617619615732 Affinity Capture-MS
OSBPL10CUL111403219615732 Affinity Capture-MS
OSBPL10CUL112538519615732 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
CUL1CUL15434011961546 Cul1 [15-410] interacts with Cul1 [411-776] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex.
RBX1CUL15027111956208 CUL1 interacts with ROC1.
RBX1CUL15434111961546 Rbx1 interacts with Cul1 [411-776] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex.
COMMD1CUL15497314685242 Murr1 interacts with Cul1 a component of the Cul1-Rbx1-Skp1-F Box Scf Ubiquitin Ligase complex.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1349658
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-2603'