AutismKB 2.0

Annotation Details for IRS4


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Basic Information Top
Gene Symbol:IRS4 ( IRS-4,PY160 )
Gene Full Name: insulin receptor substrate 4
Band: Xq22.3
Quick LinksEntrez ID:8471; OMIM: 603510; Uniprot ID:IRS4_HUMAN; ENSEMBL ID: ENSG00000133124; HGNC ID: 6128
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829IBA-cytosol-
GO:0005886IBA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0004871IBA-signal transducer activity-
GO:0005070TAS-SH3/SH2 adaptor activity9261155
GO:0005158IBA-insulin receptor binding-
GO:0005515IPI-protein binding11316748
GO:0043548IBA-phosphatidylinositol 3-kinase binding-
GO ID Evidence Qualifier GO_term References
GO:0007165TAS-signal transduction9261155
GO:0008286IBA-insulin receptor signaling pathway-
GO:0009967IEA-positive regulation of signal transduction-
GO:0019216IBA-regulation of lipid metabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
IRS4ALK10673914968112 Affinity Capture-MS
IRS4ALK11404814968112 Affinity Capture-MS
IRS4CRK1077889614078 11316748 Affinity Capture-Western; Reconstituted Complex
IRS4CRK1140489614078 11316748 Affinity Capture-Western; Reconstituted Complex
IRS4CRKL1077899614078 Reconstituted Complex
IRS4CRKL1140489614078 Reconstituted Complex
IRS4GRB21091429553137 Affinity Capture-Western
IRS4GRB21140489553137 Affinity Capture-Western
IRS4HSPA411404811912194 Affinity Capture-MS
IRS4HSPA410954011912194 Affinity Capture-MS
IRS4HSP90AA111404811912194 Affinity Capture-MS
IRS4HSP90AA110955211912194 Affinity Capture-MS
IRS4PIK3CA11130811912194 Affinity Capture-MS
IRS4PIK3CA11404811912194 Affinity Capture-MS
NISCHIRS411635811912194 Affinity Capture-MS; Affinity Capture-Western
NISCHIRS411404811912194 Affinity Capture-MS; Affinity Capture-Western
SOCS6IRS411471912052866 Affinity Capture-MS
SOCS6IRS411404812052866 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1338009
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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