Gene Symbol:	HAVCR2 ( FLJ14428,KIM-3,TIM3,TIMD3,Tim-3 )
Gene Full Name:	hepatitis A virus cellular receptor 2
Band:	5q33.3
Quick Links	Entrez ID:84868; OMIM: 606652; Uniprot ID:TIMD3_HUMAN; ENSEMBL ID: ENSG00000135077; HGNC ID: 18437
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0001772	IEA	-	immunological synapse	-
GO:0005769	IEA	-	early endosome	-
GO:0009986	IDA	-	cell surface	25363763
GO:0016021	IEA	-	integral component of membrane	-
GO:0030054	IEA	-	cell junction	-
GO:0070062	IDA	-	extracellular exosome	23376485

GO ID	Evidence	Qualifier	GO_term	References
GO:0005515	IPI	-	protein binding	25363763
GO:0046872	IEA	-	metal ion binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0002250	IEA	-	adaptive immune response	-
GO:0002281	IEA	-	macrophage activation involved in immune response	-
GO:0002519	IMP	-	natural killer cell tolerance induction	25578313
GO:0002652	IEA	-	regulation of tolerance induction dependent upon immune response	-
GO:0002826	IEA	-	negative regulation of T-helper 1 type immune response	-
GO:0002859	IEA	-	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	-
GO:0006954	IEA	-	inflammatory response	-
GO:0010629	IMP	-	negative regulation of gene expression	25578313
GO:0030886	IMP	-	negative regulation of myeloid dendritic cell activation	22842346
GO:0032088	IMP	-	negative regulation of NF-kappaB transcription factor activity	22842346
GO:0032687	IDA	-	negative regulation of interferon-alpha production	26492563
GO:0032689	IDA	-	negative regulation of interferon-gamma production	26492563
GO:0032703	IDA	-	negative regulation of interleukin-2 production	26492563
GO:0032712	IDA	-	negative regulation of interleukin-3 production	26492563
GO:0032715	IEA	-	negative regulation of interleukin-6 production	-
GO:0032720	IMP	-	negative regulation of tumor necrosis factor production	25578313
GO:0032722	IEA	-	positive regulation of chemokine production	-
GO:0032729	IEA	-	positive regulation of interferon-gamma production	-
GO:0032732	IEA	-	positive regulation of interleukin-1 production	-
GO:0032753	IMP	-	positive regulation of interleukin-4 production	25578313
GO:0032815	IEA	-	negative regulation of natural killer cell activation	-
GO:0034138	IEA	-	toll-like receptor 3 signaling pathway	-
GO:0034154	IEA	-	toll-like receptor 7 signaling pathway	-
GO:0034162	IEA	-	toll-like receptor 9 signaling pathway	-
GO:0042102	IEA	-	positive regulation of T cell proliferation	-
GO:0042130	IEA	-	negative regulation of T cell proliferation	-
GO:0043032	IEA	-	positive regulation of macrophage activation	-
GO:0045087	IEA	-	innate immune response	-
GO:0050830	IEA	-	defense response to Gram-positive bacterium	-
GO:0060135	IDA	-	maternal process involved in female pregnancy	25578313
GO:0070374	IEA	-	positive regulation of ERK1 and ERK2 cascade	-
GO:0071222	IEA	-	cellular response to lipopolysaccharide	-
GO:0071656	IDA	-	negative regulation of granulocyte colony-stimulating factor production	26492563
GO:1900425	IEA	-	negative regulation of defense response to bacterium	-
GO:1900426	IEA	-	positive regulation of defense response to bacterium	-
GO:1901224	IEA	-	positive regulation of NIK/NF-kappaB signaling	-
GO:1904469	IMP	-	positive regulation of tumor necrosis factor secretion	18006747
GO:2000521	IEA	-	negative regulation of immunological synapse formation	-
GO:2001189	IDA	-	negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	26492563

AutismKB 2.0

Annotation Details for HAVCR2

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Syndromic Genes

Non-syndromic Genes

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