AutismKB 2.0

Annotation Details for FBXO18


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Basic Information Top
Gene Symbol:FBXO18 ( FBH1,FLJ14590,Fbx18,MGC131916,MGC141935,MGC141937 )
Gene Full Name: F-box protein, helicase, 18
Band: 10p15.1
Quick LinksEntrez ID:84893; OMIM: 607222; Uniprot ID:FBX18_HUMAN; ENSEMBL ID: ENSG00000134452; HGNC ID: 13620
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000785IDA-chromatin23319600
GO:0005634IDA-nucleus19736316
GO:0019005IDA-SCF ubiquitin ligase complex11956208
GO ID Evidence Qualifier GO_term References
GO:0003678IDA-DNA helicase activity19736316
GO:0003678IMP-DNA helicase activity23361013
GO:0003690IDA-double-stranded DNA binding23393192
GO:0003697IDA-single-stranded DNA binding19736316
GO:0004003IEA-ATP-dependent DNA helicase activity-
GO:0005515IPI-protein binding23393192
GO:0005524IEA-ATP binding-
GO:0015616IDA-DNA translocase activity24108124
GO:0043138IDA-3'-5' DNA helicase activity11956208
GO ID Evidence Qualifier GO_term References
GO:0000724ISS-double-strand break repair via homologous recombination-
GO:0000737IMP-DNA catabolic process, endonucleolytic23361013
GO:0001934IMP-positive regulation of protein phosphorylation23361013
GO:0006974IDA-cellular response to DNA damage stimulus19736316
GO:0008219IDA-cell death23319600
GO:0008219IMP-cell death23361013
GO:0016567IDA-protein ubiquitination25585578
GO:0016567IEA-protein ubiquitination-
GO:0031297IDA-replication fork processing25585578
GO:0032508IEA-DNA duplex unwinding-
GO:0035562IEA-negative regulation of chromatin binding-
GO:0048478ISS-replication fork protection-
GO:0072429IMP-response to intra-S DNA damage checkpoint signaling23361013
GO:1902231IMP-positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage23361013
GO:2000042IDA-negative regulation of double-strand break repair via homologous recombination19736316
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FBXO18SKP112433311956208 15118074 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXO18SKP111239111956208 15118074 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXO18CUL111403211956208 15118074 Affinity Capture-Western; Reconstituted Complex
FBXO18CUL112433311956208 15118074 Affinity Capture-Western; Reconstituted Complex
FBXO18RBX111530111956208 15118074 Affinity Capture-Western; Reconstituted Complex
FBXO18RBX112433311956208 15118074 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1354699
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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