AutismKB 2.0

Annotation Details for ITGA8


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Basic Information Top
Gene Symbol:ITGA8 ( - )
Gene Full Name: integrin, alpha 8
Band: 10p13
Quick LinksEntrez ID:8516; OMIM: 604063; Uniprot ID:ITA8_HUMAN; ENSEMBL ID: ENSG00000077943; HGNC ID: 6144
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005783IDA-endoplasmic reticulum24439109
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0008305TAS-integrin complex7768999
GO:0009986IDA-cell surface24439109
GO:0014069IEA-postsynaptic density-
GO:0032591IEA-dendritic spine membrane-
GO:0034678TAS-integrin alpha8-beta1 complex21335239
GO:0043204IEA-perikaryon-
GO:0045177IEA-apical part of cell-
GO ID Evidence Qualifier GO_term References
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001656IEA-metanephros development-
GO:0001822IMP-kidney development24439109
GO:0007160IMP-cell-matrix adhesion24439109
GO:0007160NAS-cell-matrix adhesion7768999
GO:0007229IEA-integrin-mediated signaling pathway-
GO:0007420IEA-brain development-
GO:0007613IEA-memory-
GO:0016337NAS-single organismal cell-cell adhesion7768999
GO:0030030IEA-cell projection organization-
GO:0030198TAS-extracellular matrix organization-
GO:0030511IEA-positive regulation of transforming growth factor beta receptor signaling pathway-
GO:0034446IMP-substrate adhesion-dependent cell spreading24439109
GO:0042472IEA-inner ear morphogenesis-
GO:0045184IEA-establishment of protein localization-
GO:0048333IEP-mesodermal cell differentiation23154389
GO:0048745IEA-smooth muscle tissue development-
GO:2000721IEA-positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGA8ITGB11140887768999 Affinity Capture-Western
ITGA8ITGB11098947768999 Affinity Capture-Western
NPNTITGA812911711470831 Affinity Capture-Western; Reconstituted Complex
NPNTITGA811408811470831 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109442
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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