AutismKB 2.0

Annotation Details for TRIM5


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Basic Information Top
Gene Symbol:TRIM5 ( RNF88,TRIM5alpha )
Gene Full Name: tripartite motif-containing 5
Band: 11p15.4
Quick LinksEntrez ID:85363; OMIM: 608487; Uniprot ID:TRIM5_HUMAN; ENSEMBL ID: ENSG00000132256; HGNC ID: 16276
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000932IDA-P-body20357094
GO:0005634IEA-nucleus-
GO:0005737IDA-cytoplasm18248090
GO:0005829TAS-cytosol-
GO:1990462IDAcolocalizes_withomegasome25127057
GO ID Evidence Qualifier GO_term References
GO:0004842IDA-ubiquitin-protein transferase activity21512573
GO:0005515IPI-protein binding20357094
GO:0008270IEA-zinc ion binding-
GO:0008329IDA-signaling pattern recognition receptor activity21512573
GO:0019901IPI-protein kinase binding25127057
GO:0030674IPI-protein binding, bridging25127057
GO:0042802IPI-identical protein binding22493164
GO:0042803IPI-protein homodimerization activity11331580
GO ID Evidence Qualifier GO_term References
GO:0002218IDA-activation of innate immune response21512573
GO:0002221IEA-pattern recognition receptor signaling pathway-
GO:0006914IDA-autophagy25127057
GO:0031664IMP-regulation of lipopolysaccharide-mediated signaling pathway21512573
GO:0032880IMP-regulation of protein localization25127057
GO:0043123IDA-positive regulation of I-kappaB kinase/NF-kappaB signaling23077300
GO:0043123IMP-positive regulation of I-kappaB kinase/NF-kappaB signaling21512573
GO:0043410IMP-positive regulation of MAPK cascade21512573
GO:0045087IDA-innate immune response18248090
GO:0046597IDA-negative regulation of viral entry into host cell18248090
GO:0051091IMP-positive regulation of sequence-specific DNA binding transcription factor activity23077300
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity21512573
GO:0051607TAS-defense response to virus21512573
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:0070534IDA-protein K63-linked ubiquitination21512573
GO:1902187IDA-negative regulation of viral release from host cell18248090
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:3646853
  • Data Attributes: HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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