AutismKB 2.0

Annotation Details for MADD


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Basic Information Top
Gene Symbol:MADD ( DENN,FLJ35600,FLJ36300,IG20,KIAA0358,RAB3GEP )
Gene Full Name: MAP-kinase activating death domain
Band: 11p11.2
Quick LinksEntrez ID:8567; OMIM: 603584; Uniprot ID:MADD_HUMAN; ENSEMBL ID: ENSG00000110514; HGNC ID: 6766
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737TAS-cytoplasm8988362
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO:0016021IDA-integral component of membrane8988362
GO ID Evidence Qualifier GO_term References
GO:0005123TAS-death receptor binding9115275
GO:0005515IPI-protein binding9115275
GO:0017112IDA-Rab guanyl-nucleotide exchange factor activity20937701
GO:0017112IMP-Rab guanyl-nucleotide exchange factor activity9115275
GO:0017112TAS-Rab guanyl-nucleotide exchange factor activity-
GO:0030295TAS-protein kinase activator activity9115275
GO ID Evidence Qualifier GO_term References
GO:0000187IMP-activation of MAPK activity9115275
GO:0007166TAS-cell surface receptor signaling pathway9115275
GO:0010803TAS-regulation of tumor necrosis factor-mediated signaling pathway-
GO:0032483IDA-regulation of Rab protein signal transduction20937701
GO:0042981IMP-regulation of apoptotic process11577081
GO:0043547IEA-positive regulation of GTPase activity-
GO:0051726IMP-regulation of cell cycle14735464
GO:0061024TAS-membrane organization-
GO:0097194IMP-execution phase of apoptosis14735464
GO:1902041IMP-regulation of extrinsic apoptotic signaling pathway via death domain receptors9115275
GO:2001236IDA-regulation of extrinsic apoptotic signaling pathway11577081
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MADDTNFRSF1A1129869115275 Reconstituted Complex
MADDTNFRSF1A1141369115275 Reconstituted Complex
MADDYWHAZ11336620936779 Two-hybrid
MADDYWHAZ11413620936779 Two-hybrid
LRDDMADD12064510825539 Affinity Capture-Western
LRDDMADD11413610825539 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2444672
  • Data Attributes: MGI curated and HomoloGene calculated
No data