AutismKB 2.0

Annotation Details for CASK


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Basic Information Top
Gene Symbol:CASK ( CAGH39,CAMGUK,CMG,FGS4,FLJ22219,FLJ31914,LIN2,MICPCH,TNRC8 )
Gene Full Name: calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Band: Xp11.4
Quick LinksEntrez ID:8573; OMIM: 300172; Uniprot ID:CSKP_HUMAN; ENSEMBL ID: ENSG00000147044; HGNC ID: 1497
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005604IDA-basement membrane18664494
GO:0005604IDAcolocalizes_withbasement membrane18664494
GO:0005652IDA-nuclear lamina18664494
GO:0005730IDA-nucleolus18664494
GO:0005737IDA-cytoplasm18664494
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane9660868
GO:0005911IDA-cell-cell junction18664494
GO:0005925IDA-focal adhesion21423176
GO:0015629TAS-actin cytoskeleton9660868
GO:0016323IEA-basolateral plasma membrane-
GO:0016363IDA-nuclear matrix18664494
GO:0031982IEA-vesicle-
GO:0042734ISS-presynaptic membrane-
GO:0060170ISS-ciliary membrane-
GO ID Evidence Qualifier GO_term References
GO:0004385TAS-guanylate kinase activity9660868
GO:0004674IEA-protein serine/threonine kinase activity-
GO:0005515IPI-protein binding9660868
GO:0005516IEA-calmodulin binding-
GO:0005524IEA-ATP binding-
GO:0042043IEA-neurexin family protein binding-
GO ID Evidence Qualifier GO_term References
GO:0001953IMP-negative regulation of cell-matrix adhesion18664494
GO:0006468IEA-protein phosphorylation-
GO:0007155TAS-cell adhesion9660868
GO:0007269TAS-neurotransmitter secretion-
GO:0010839IDA-negative regulation of keratinocyte proliferation18664494
GO:0010839IMP-negative regulation of keratinocyte proliferation18664494
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0046037IEA-GMP metabolic process-
GO:0046710IEA-GDP metabolic process-
GO:0061045IMP-negative regulation of wound healing18664494
GO:0070509IEA-calcium ion import-
GO:0090280IEA-positive regulation of calcium ion import-
GO:0090288IMP-negative regulation of cellular response to growth factor stimulus18664494
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CASKAPBA11068179822620 9952408 Affinity Capture-Western; Reconstituted Complex
CASKAPBA11141419822620 9952408 Affinity Capture-Western; Reconstituted Complex
CASKATP2B410698312511555 Co-fractionation; Reconstituted Complex
CASKATP2B411414112511555 Co-fractionation; Reconstituted Complex
CASKDLG110808310993877 12151521 14960569 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CASKDLG111414110993877 12151521 14960569 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CASKDLG411414112151521 Affinity Capture-Western; Two-hybrid
CASKDLG410808612151521 Affinity Capture-Western; Two-hybrid
CASKEPB411083499660868 Reconstituted Complex
CASKEPB411141419660868 Reconstituted Complex
CASKID111414115694377 Reconstituted Complex; Two-hybrid
CASKID110962315694377 Reconstituted Complex; Two-hybrid
CASKKCNJ410996314960569 15024025 Affinity Capture-Western
CASKKCNJ411414114960569 15024025 Affinity Capture-Western
CASKKCNJ1210997014960569 15024025 Affinity Capture-MS; Affinity Capture-Western
CASKKCNJ1211414114960569 15024025 Affinity Capture-MS; Affinity Capture-Western
CASKNPHS111092815331416 Affinity Capture-MS; Reconstituted Complex
CASKNPHS111414115331416 Affinity Capture-MS; Reconstituted Complex
CASKPARK211110511679592 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
CASKPARK211414111679592 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
CASKSDC11122849660868 Reconstituted Complex
CASKSDC11141419660868 Reconstituted Complex
CASKSDC21122859660868 12676536 Affinity Capture-Western; Reconstituted Complex
CASKSDC21141419660868 12676536 Affinity Capture-Western; Reconstituted Complex
LIN7ACASK1143529822620 14960569 Affinity Capture-Western; Reconstituted Complex
LIN7ACASK1141419822620 14960569 Affinity Capture-Western; Reconstituted Complex
C16orf70CASK1141419822620 Reconstituted Complex
C16orf70CASK1232049822620 Reconstituted Complex
TBR1CASK11594210749215 15066269 Affinity Capture-Western; Two-hybrid
TBR1CASK11414110749215 15066269 Affinity Capture-Western; Two-hybrid
F11RCASK11915310856295 11120739 Affinity Capture-Western; Reconstituted Complex
F11RCASK11414110856295 11120739 Affinity Capture-Western; Reconstituted Complex
RPH3ACASK11656011377421 Affinity Capture-Western; Reconstituted Complex
RPH3ACASK11414111377421 Affinity Capture-Western; Reconstituted Complex
CNTNAP2CASK11751012093160 Reconstituted Complex
CNTNAP2CASK11414112093160 Reconstituted Complex
CNTNAP4CASK11414112093160 Reconstituted Complex
CNTNAP4CASK12453212093160 Reconstituted Complex
FCHSD2CASK11414114627983 Reconstituted Complex
FCHSD2CASK11520514627983 Reconstituted Complex
LIN7CCASK12060814960569 Affinity Capture-Western
LIN7CCASK11414114960569 Affinity Capture-Western
LIN7BCASK12207914960569 Affinity Capture-Western
LIN7BCASK11414114960569 Affinity Capture-Western
TSPYL2CASK12203415066269 Affinity Capture-Western; Two-hybrid
TSPYL2CASK11414115066269 Affinity Capture-Western; Two-hybrid
CD2APCASK11714015331416 Reconstituted Complex
CD2APCASK11414115331416 Reconstituted Complex
HGSCASK11459319019082 Reconstituted Complex
HGSCASK11414119019082 Reconstituted Complex
UIMC1CASK11969719615732 Affinity Capture-MS
UIMC1CASK11414119615732 Affinity Capture-MS
SPATA2CASK11414119615732 Affinity Capture-MS
SPATA2CASK11516319615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1309489
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-020802-4'