AutismKB 2.0

Annotation Details for RUNX2


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Basic Information Top
Gene Symbol:RUNX2 ( AML3,CBFA1,CCD,CCD1,MGC120022,MGC120023,OSF-2,OSF2,PEA2aA,PEBP2A1,PEBP2A2,PEBP2aA,PEBP2aA1 )
Gene Full Name: runt-related transcription factor 2
Band: 6p21.1
Quick LinksEntrez ID:860; OMIM: 600211; Uniprot ID:RUNX2_HUMAN; ENSEMBL ID: ENSG00000124813; HGNC ID: 10472
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790ISS-nuclear chromatin-
GO:0005634IBA-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0005667IEA-transcription factor complex-
GO:0005737IEA-cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0000978IEA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0000979IEA-RNA polymerase II core promoter sequence-specific DNA binding-
GO:0000981IBA-RNA polymerase II transcription factor activity, sequence-specific DNA binding-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003682IEA-chromatin binding-
GO:0003700NAS-transcription factor activity, sequence-specific DNA binding9182765
GO:0005515IPI-protein binding11965546
GO:0005524IEA-ATP binding-
GO:0019904IEA-protein domain specific binding-
GO:0043425IEA-bHLH transcription factor binding-
GO:0070491IEA-repressing transcription factor binding-
GO ID Evidence Qualifier GO_term References
GO:0001503TAS-ossification12217689
GO:0001649IEP-osteoblast differentiation20128911
GO:0001649TAS-osteoblast differentiation12217689
GO:0001958IEA-endochondral ossification-
GO:0002051IEA-osteoblast fate commitment-
GO:0002062IBA-chondrocyte differentiation-
GO:0002063IEA-chondrocyte development-
GO:0002076IEA-osteoblast development-
GO:0006357IBA-regulation of transcription from RNA polymerase II promoter-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0008284IEA-positive regulation of cell proliferation-
GO:0030097IBA-hemopoiesis-
GO:0030182IBA-neuron differentiation-
GO:0030217IEA-T cell differentiation-
GO:0030509ISS-BMP signaling pathway-
GO:0032332IEA-positive regulation of chondrocyte differentiation-
GO:0035115IEA-embryonic forelimb morphogenesis-
GO:0040036IEA-regulation of fibroblast growth factor receptor signaling pathway-
GO:0042475IEA-odontogenesis of dentin-containing tooth-
GO:0042487IEA-regulation of odontogenesis of dentin-containing tooth-
GO:0045595IBA-regulation of cell differentiation-
GO:0045669IEA-positive regulation of osteoblast differentiation-
GO:0045879IEA-negative regulation of smoothened signaling pathway-
GO:0045892IDA-negative regulation of transcription, DNA-templated11965546
GO:0045893IDA-positive regulation of transcription, DNA-templated11965546
GO:0048469IEA-cell maturation-
GO:0048701IEA-embryonic cranial skeleton morphogenesis-
GO:0048863IEA-stem cell differentiation-
GO:0071773ISS-cellular response to BMP stimulus-
GO:1901522ISS-positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RUNX2BMPR1A10712516613856 Affinity Capture-Western
RUNX2BMPR1A10730816613856 Affinity Capture-Western
THOC4RUNX21154869119228 Reconstituted Complex
THOC4RUNX21073089119228 Reconstituted Complex
ETS1RUNX21073089794229 Reconstituted Complex
ETS1RUNX21084149794229 Reconstituted Complex
YAP1RUNX210730810228168 Reconstituted Complex
YAP1RUNX211568410228168 Reconstituted Complex
SMAD1RUNX211026110531362 10962029 Affinity Capture-Western
SMAD1RUNX210730810531362 10962029 Affinity Capture-Western
SMAD2RUNX210730810531362 Affinity Capture-Western
SMAD2RUNX211026210531362 Affinity Capture-Western
SMAD5RUNX211026510531362 Affinity Capture-Western
SMAD5RUNX210730810531362 Affinity Capture-Western
SMAD3RUNX210730810531362 10962029 Affinity Capture-Western; Reconstituted Complex
SMAD3RUNX211026310531362 10962029 Affinity Capture-Western; Reconstituted Complex
FOSRUNX210863611274169 11641401 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FOSRUNX210730811274169 11641401 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUNRUNX210992811274169 11641401 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUNRUNX210730811274169 11641401 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MSX2RUNX210730811683913 Affinity Capture-Western
MSX2RUNX211059411683913 Affinity Capture-Western
MYST4RUNX211706911965546 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MYST4RUNX210730811965546 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
XRCC6RUNX210730812145306 Affinity Capture-Western
XRCC6RUNX210882212145306 Affinity Capture-Western
XRCC5RUNX211335312145306 Affinity Capture-Western
XRCC5RUNX210730812145306 Affinity Capture-Western
HDAC6RUNX210730812391164 Affinity Capture-Western
HDAC6RUNX211533012391164 Affinity Capture-Western
HDAC3RUNX211436815292260 18321663 Affinity Capture-Western; Reconstituted Complex
HDAC3RUNX210730815292260 18321663 Affinity Capture-Western; Reconstituted Complex
HDAC4RUNX210730815537544 16613856 20097749 Affinity Capture-Western
HDAC4RUNX211510615537544 16613856 20097749 Affinity Capture-Western
HDAC5RUNX210730815990875 16613856 Affinity Capture-Western
HDAC5RUNX211533115990875 16613856 Affinity Capture-Western
HES1RUNX210730816195230 Affinity Capture-Western; Co-localization
HES1RUNX210951416195230 Affinity Capture-Western; Co-localization
EP300RUNX210834716613856 16728531 Affinity Capture-Western
EP300RUNX210730816613856 16728531 Affinity Capture-Western
KAT2BRUNX211437516613856 Affinity Capture-Western
KAT2BRUNX210730816613856 Affinity Capture-Western
HDAC1RUNX210730816728531 Affinity Capture-Western
HDAC1RUNX210931516728531 Affinity Capture-Western
HDAC7RUNX211961317997710 Affinity Capture-Western; Co-localization; Reconstituted Complex
HDAC7RUNX210730817997710 Affinity Capture-Western; Co-localization; Reconstituted Complex
CREBBPRUNX210730818321663 Affinity Capture-Western
CREBBPRUNX210777718321663 Affinity Capture-Western
STUB1RUNX210730818541707 Affinity Capture-Western; Two-hybrid
STUB1RUNX211556318541707 Affinity Capture-Western; Two-hybrid
TLE1RUNX211294320160071 Affinity Capture-Western; Co-localization
TLE1RUNX210730820160071 Affinity Capture-Western; Co-localization
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99829
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040629-3'