AutismKB 2.0

Annotation Details for TNFSF11


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Basic Information Top
Gene Symbol:TNFSF11 ( CD254,ODF,OPGL,OPTB2,RANKL,TRANCE,hRANKL2,sOdf )
Gene Full Name: tumor necrosis factor (ligand) superfamily, member 11
Band: 13q14
Quick LinksEntrez ID:8600; OMIM: 602642; Uniprot ID:TNF11_HUMAN; ENSEMBL ID: ENSG00000120659; HGNC ID: 11926
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region9568710
GO:0005576TAS-extracellular region-
GO:0005615IEA-extracellular space-
GO:0005737IEA-cytoplasm-
GO:0005886TAS-plasma membrane-
GO:0005887NAS-integral component of plasma membrane9312132
GO ID Evidence Qualifier GO_term References
GO:0005125IDA-cytokine activity9367155
GO:0005125NAS-cytokine activity9568710
GO:0005164NAS-tumor necrosis factor receptor binding9312132
GO:0032813IC-tumor necrosis factor receptor superfamily binding19940926
GO ID Evidence Qualifier GO_term References
GO:0001503IEA-ossification-
GO:0002158IEA-osteoclast proliferation-
GO:0002548IDA-monocyte chemotaxis15248232
GO:0006955NAS-immune response9312132
GO:0007257IEA-activation of JUN kinase activity-
GO:0009887IEA-animal organ morphogenesis-
GO:0019221IDA-cytokine-mediated signaling pathway15248232
GO:0019722ISS-calcium-mediated signaling-
GO:0030316IDA-osteoclast differentiation18606301
GO:0030316ISS-osteoclast differentiation-
GO:0030316NAS-osteoclast differentiation9568710
GO:0033209ISS-tumor necrosis factor-mediated signaling pathway19940926
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0033598IEA-mammary gland epithelial cell proliferation-
GO:0034112IDA-positive regulation of homotypic cell-cell adhesion9367155
GO:0038001IEA-paracrine signaling-
GO:0043123IEA-positive regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0043406IDA-positive regulation of MAP kinase activity15304486
GO:0045453IEA-bone resorption-
GO:0045672IDA-positive regulation of osteoclast differentiation15304486
GO:0045780IDA-positive regulation of bone resorption17241109
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter15304486
GO:0050870IDA-positive regulation of T cell activation9367155
GO:0051091ISS-positive regulation of sequence-specific DNA binding transcription factor activity19940926
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity9367155
GO:0051260IEA-protein homooligomerization-
GO:0051466ISS-positive regulation of corticotropin-releasing hormone secretion19940926
GO:0051897IEA-positive regulation of protein kinase B signaling-
GO:0055074IEA-calcium ion homeostasis-
GO:0060749IEA-mammary gland alveolus development-
GO:0070371IEA-ERK1 and ERK2 cascade-
GO:0071812ISS-positive regulation of fever generation by positive regulation of prostaglandin secretion19940926
GO:0071847IDA-TNFSF11-mediated signaling pathway18606301
GO:0071848IDA-positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling18606301
GO:1902533IDA-positive regulation of intracellular signal transduction15248232
GO:2001206IEA-positive regulation of osteoclast development-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TNFSF11TNFRSF11B1110289520411 Reconstituted Complex
TNFSF11TNFRSF11B1141609520411 Reconstituted Complex
TNFSF11SRC11259210635328 Affinity Capture-Western
TNFSF11SRC11416010635328 Affinity Capture-Western
KHDRBS1TNFSF1111416010635328 Biochemical Activity
KHDRBS1TNFSF1111590010635328 Biochemical Activity
ZNF675TNFSF1112811611751921 Phenotypic Suppression
ZNF675TNFSF1111416011751921 Phenotypic Suppression
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1100089
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090805-2'