AutismKB 2.0

Annotation Details for RUNX1


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Basic Information Top
Gene Symbol:RUNX1 ( AML1,AML1-EVI-1,AMLCR1,CBFA2,EVI-1,PEBP2aB )
Gene Full Name: runt-related transcription factor 1
Band: 21q22.12
Quick LinksEntrez ID:861; OMIM: 151385; Uniprot ID:RUNX1_HUMAN; ENSEMBL ID: ENSG00000159216; HGNC ID: 10471
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus7862156
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO ID Evidence Qualifier GO_term References
GO:0000975IDA-regulatory region DNA binding21873977
GO:0000977IDA-RNA polymerase II regulatory region sequence-specific DNA binding9199349
GO:0000977IMP-RNA polymerase II regulatory region sequence-specific DNA binding9199349
GO:0001047IDA-core promoter binding17377532
GO:0001228IDA-transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding9199349
GO:0001228IMP-transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding9199349
GO:0005515IPI-protein binding2845103
GO:0005524IEA-ATP binding-
GO ID Evidence Qualifier GO_term References
GO:0001503IBA-ossification-
GO:0002062IBA-chondrocyte differentiation-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0030097IDA-hemopoiesis21873977
GO:0030854IMP-positive regulation of granulocyte differentiation9199349
GO:0032743IMP-positive regulation of interleukin-2 production17377532
GO:0045766ISS-positive regulation of angiogenesis-
GO:0045893IDA-positive regulation of transcription, DNA-templated10207087
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter9199349
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter9199349
GO:0048935TAS-peripheral nervous system neuron development20096094
GO:0071425TAS-hematopoietic stem cell proliferation21873977
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RUNX1AES10667510825294 Two-hybrid
RUNX1AES10730910825294 Two-hybrid
CEBPBRUNX11074808622667 Reconstituted Complex
CEBPBRUNX11073098622667 Reconstituted Complex
CBFA2T2RUNX11073099447981 Affinity Capture-Western
CBFA2T2RUNX11145869447981 Affinity Capture-Western
TLE1RUNX11129439751710 Far Western; Two-hybrid
TLE1RUNX11073099751710 Far Western; Two-hybrid
ELF4RUNX110730910207087 Affinity Capture-Western; Reconstituted Complex
ELF4RUNX110831510207087 Affinity Capture-Western; Reconstituted Complex
EFNA2RUNX110730910207087 Reconstituted Complex
EFNA2RUNX110826310207087 Reconstituted Complex
ELF2RUNX110730910207087 Reconstituted Complex
ELF2RUNX110831310207087 Reconstituted Complex
ETS1RUNX110730910207087 Reconstituted Complex
ETS1RUNX110841410207087 Reconstituted Complex
YAP1RUNX110730910228168 Two-hybrid
YAP1RUNX111568410228168 Two-hybrid
PAX5RUNX111111310455134 Reconstituted Complex
PAX5RUNX110730910455134 Reconstituted Complex
SMAD1RUNX111026110531362 Affinity Capture-Western
SMAD1RUNX110730910531362 Affinity Capture-Western
SMAD2RUNX111026210531362 Affinity Capture-Western
SMAD2RUNX110730910531362 Affinity Capture-Western
SMAD3RUNX111026310531362 Affinity Capture-Western
SMAD3RUNX110730910531362 Affinity Capture-Western
SMAD5RUNX111026510531362 Affinity Capture-Western
SMAD5RUNX110730910531362 Affinity Capture-Western
CBFBRUNX110730910856244 11742995 14729951 20195544 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure
CBFBRUNX110731310856244 11742995 14729951 20195544 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure
RUNX1T1RUNX110731010882117 Co-purification
RUNX1T1RUNX110730910882117 Co-purification
NCOR1RUNX111497310882117 Reconstituted Complex
NCOR1RUNX110730910882117 Reconstituted Complex
FOSRUNX110863611274169 11641401 Affinity Capture-Western; Reconstituted Complex
FOSRUNX110730911274169 11641401 Affinity Capture-Western; Reconstituted Complex
JUNRUNX110992811274169 11641401 Affinity Capture-Western; Reconstituted Complex
JUNRUNX110730911274169 11641401 Affinity Capture-Western; Reconstituted Complex
MYST3RUNX110730911742995 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
MYST3RUNX111370311742995 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
MYST4RUNX111706911965546 Affinity Capture-Western
MYST4RUNX110730911965546 Affinity Capture-Western
VDRRUNX111326412460926 Affinity Capture-Western; Reconstituted Complex
VDRRUNX110730912460926 Affinity Capture-Western; Reconstituted Complex
SUV39H1RUNX111270612917624 16652147 Affinity Capture-Western; Co-purification; Reconstituted Complex
SUV39H1RUNX110730912917624 16652147 Affinity Capture-Western; Co-purification; Reconstituted Complex
SIN3ARUNX110730914729951 Affinity Capture-Western
SIN3ARUNX111743914729951 Affinity Capture-Western
TCF3RUNX111279115333839 Affinity Capture-Western
TCF3RUNX110730915333839 Affinity Capture-Western
TCF12RUNX111279815333839 Affinity Capture-Western
TCF12RUNX110730915333839 Affinity Capture-Western
UBCRUNX111316416046550 Affinity Capture-Western
UBCRUNX110730916046550 Affinity Capture-Western
HDAC1RUNX110931516652147 Affinity Capture-Western
HDAC1RUNX110730916652147 Affinity Capture-Western
HDAC3RUNX111436816652147 Affinity Capture-Western
HDAC3RUNX110730916652147 Affinity Capture-Western
EP300RUNX110834716917507 Affinity Capture-Western
EP300RUNX110730916917507 Affinity Capture-Western
HIPK2RUNX111881516917507 Affinity Capture-Western; Biochemical Activity
HIPK2RUNX110730916917507 Affinity Capture-Western; Biochemical Activity
HDAC2RUNX110931618073335 Affinity Capture-Western
HDAC2RUNX110730918073335 Affinity Capture-Western
PMLRUNX111138418073335 Affinity Capture-Western
PMLRUNX110730918073335 Affinity Capture-Western
RARARUNX111184918073335 Affinity Capture-Western
RARARUNX110730918073335 Affinity Capture-Western
SIAH1RUNX111237218073335 Affinity Capture-Western
SIAH1RUNX110730918073335 Affinity Capture-Western
RUNX1RUNX110730918073335 Affinity Capture-Western
UBE2L6RUNX111467218073335 Reconstituted Complex
UBE2L6RUNX110730918073335 Reconstituted Complex
FHL2RUNX110856518768464 Affinity Capture-Western
FHL2RUNX110730918768464 Affinity Capture-Western
TRAF6RUNX111304118768464 Affinity Capture-Western
TRAF6RUNX110730918768464 Affinity Capture-Western
MYOD1RUNX111073720195544 Affinity Capture-Western; Reconstituted Complex
MYOD1RUNX110730920195544 Affinity Capture-Western; Reconstituted Complex
NR4A2RUNX111098321468021 Affinity Capture-Western
NR4A2RUNX110730921468021 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
RUNX1rs4816501 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
RUNX1rs2268277 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:99852
  • Data Attributes: MGI curated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000605-1'