AutismKB 2.0

Annotation Details for TP63


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Basic Information Top
Gene Symbol:TP63 ( AIS,B(p51A),B(p51B),EEC3,KET,LMS,NBP,OFC8,RHS,SHFM4,TP53CP,TP53L,TP73L,p40,p51,p53CP,p63,p73H,p73L )
Gene Full Name: tumor protein p63
Band: 3q28
Quick LinksEntrez ID:8626; OMIM: 603273; Uniprot ID:P63_HUMAN; ENSEMBL ID: ENSG00000073282; HGNC ID: 15979
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin22521434
GO:0005634IDA-nucleus10657951
GO:0005634NAS-nucleus9774969
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005667IBA-transcription factor complex-
GO:0005737IDA-cytoplasm10657951
GO:0005739IEA-mitochondrion-
GO:0005791IEA-rough endoplasmic reticulum-
GO:0005794IDA-Golgi apparatus-
GO:0005829IBA-cytosol-
GO:0005829IDA-cytosol-
GO:0030425IBA-dendrite-
GO ID Evidence Qualifier GO_term References
GO:0000989IEA-transcription factor activity, transcription factor binding-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0002039IBA-p53 binding-
GO:0002039IPI-p53 binding25417702
GO:0003677NAS-DNA binding9662346
GO:0003682IBA-chromatin binding-
GO:0003684IBA-damaged DNA binding-
GO:0003690IBA-double-stranded DNA binding-
GO:0003700IBA-transcription factor activity, sequence-specific DNA binding-
GO:0003700IMP-transcription factor activity, sequence-specific DNA binding25417702
GO:0005515IPI-protein binding14729977
GO:0042802IPI-identical protein binding12446779
GO:0043565IBA-sequence-specific DNA binding-
GO:0044212IEA-transcription regulatory region DNA binding-
GO:0046872IEA-metal ion binding-
GO:0050699IPI-WW domain binding19451233
GO:0097371IPI-MDM2/MDM4 family protein binding25417702
GO ID Evidence Qualifier GO_term References
GO:0000122IBA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001302IEA-replicative cell aging-
GO:0001501IEA-skeletal system development-
GO:0001736IEA-establishment of planar polarity-
GO:0002053IEA-positive regulation of mesenchymal cell proliferation-
GO:0002064IEA-epithelial cell development-
GO:0006338IEA-chromatin remodeling-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006915TAS-apoptotic process9662378
GO:0006978IBA-DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator-
GO:0007219IEA-Notch signaling pathway-
GO:0007283IEA-spermatogenesis-
GO:0007499IEA-ectoderm and mesoderm interaction-
GO:0009954IEA-proximal/distal pattern formation-
GO:0010165IBA-response to X-ray-
GO:0010259IEA-multicellular organism aging-
GO:0010332IBA-response to gamma radiation-
GO:0010481IEA-epidermal cell division-
GO:0010482ISS-regulation of epidermal cell division-
GO:0010838IEA-positive regulation of keratinocyte proliferation-
GO:0030216IEA-keratinocyte differentiation-
GO:0030326IEA-embryonic limb morphogenesis-
GO:0030859IEA-polarized epithelial cell differentiation-
GO:0031069IEA-hair follicle morphogenesis-
GO:0031571IBA-mitotic G1 DNA damage checkpoint-
GO:0033147IEA-negative regulation of intracellular estrogen receptor signaling pathway-
GO:0034644IBA-cellular response to UV-
GO:0036342IEA-post-anal tail morphogenesis-
GO:0042475IEA-odontogenesis of dentin-containing tooth-
GO:0042771IBA-intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-
GO:0042981TAS-regulation of apoptotic process-
GO:0043066IBA-negative regulation of apoptotic process-
GO:0043281IEA-regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0043523IBA-regulation of neuron apoptotic process-
GO:0043589IEA-skin morphogenesis-
GO:0043616IEA-keratinocyte proliferation-
GO:0045617IEA-negative regulation of keratinocyte differentiation-
GO:0045669IMP-positive regulation of osteoblast differentiation22521434
GO:0045747IDA-positive regulation of Notch signaling pathway11641404
GO:0045892IDA-negative regulation of transcription, DNA-templated12446784
GO:0045893IDA-positive regulation of transcription, DNA-templated12446784
GO:0045893IMP-positive regulation of transcription, DNA-templated25417702
GO:0045893NAS-positive regulation of transcription, DNA-templated9774969
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter22521434
GO:0048485IEA-sympathetic nervous system development-
GO:0048745IEA-smooth muscle tissue development-
GO:0048807IEA-female genitalia morphogenesis-
GO:0051289IPI-protein homotetramerization10373484
GO:0051402IEA-neuron apoptotic process-
GO:0060157IEA-urinary bladder development-
GO:0060197IEA-cloacal septation-
GO:0060513IEA-prostatic bud formation-
GO:0060529IEA-squamous basal epithelial stem cell differentiation involved in prostate gland acinus development-
GO:0061436ISS-establishment of skin barrier-
GO:1900740TAS-positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
GO:1904674IEA-positive regulation of somatic stem cell population maintenance-
GO:2000271IDA-positive regulation of fibroblast apoptotic process9774969
GO:2000381IEA-negative regulation of mesoderm development-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TP63ADH510664020308539 Affinity Capture-Western
TP63ADH511418120308539 Affinity Capture-Western
TP63DPH111418120308539 Affinity Capture-Western
TP63DPH110813520308539 Affinity Capture-Western
TP63EMX110833120211142 Two-hybrid
TP63EMX111418120211142 Two-hybrid
TP63GAS810889220308539 Affinity Capture-Western
TP63GAS811418120308539 Affinity Capture-Western
TP63HNRNPAB11418112692135 Reconstituted Complex; Two-hybrid
TP63HNRNPAB10942312692135 Reconstituted Complex; Two-hybrid
TP63SMARCD211248720308539 Affinity Capture-Western
TP63SMARCD211418120308539 Affinity Capture-Western
TP63UBC11316415846104 17965458 Affinity Capture-Western
TP63UBC11418115846104 17965458 Affinity Capture-Western
TP63NPRL311379620308539 Affinity Capture-Western
TP63NPRL311418120308539 Affinity Capture-Western
YAP1TP6311418111278685 Reconstituted Complex
YAP1TP6311568411278685 Reconstituted Complex
HIPK2TP6311881511925430 Two-hybrid
HIPK2TP6311418111925430 Two-hybrid
GNB2L1TP6311567112692135 Two-hybrid
GNB2L1TP6311418112692135 Two-hybrid
SFRS15TP6312153612692135 Two-hybrid
SFRS15TP6311418112692135 Two-hybrid
BTRCTP6311445717965458 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BTRCTP6311418117965458 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DNAJB6TP6311536020308539 Affinity Capture-Western
DNAJB6TP6311418120308539 Affinity Capture-Western
MYL9TP6311567020308539 Affinity Capture-Western
MYL9TP6311418120308539 Affinity Capture-Western
IGF2BP1TP6311418120308539 Affinity Capture-Western
IGF2BP1TP6311588620308539 Affinity Capture-Western
BRD8TP6311418120308539 Affinity Capture-Western
BRD8TP6311610820308539 Affinity Capture-Western
RNF38TP6312741620308539 Affinity Capture-Western
RNF38TP6311418120308539 Affinity Capture-Western
DAB2IPTP6312747820308539 Affinity Capture-Western
DAB2IPTP6311418120308539 Affinity Capture-Western
ASPMTP6311418120308539 Affinity Capture-Western
ASPMTP6312923620308539 Affinity Capture-Western
EIF2C1TP6311772620308539 Affinity Capture-Western
EIF2C1TP6311418120308539 Affinity Capture-Western
EIF2C2TP6311804120308539 Affinity Capture-Western
EIF2C2TP6311418120308539 Affinity Capture-Western
N4BP2TP6312084820308539 Affinity Capture-Western
N4BP2TP6311418120308539 Affinity Capture-Western
JPH1TP6311418120308539 Affinity Capture-Western
JPH1TP6312119120308539 Affinity Capture-Western
TRMT11TP6312191820308539 Affinity Capture-Western
TRMT11TP6311418120308539 Affinity Capture-Western
C4orf41TP6312195720308539 Affinity Capture-Western
C4orf41TP6311418120308539 Affinity Capture-Western
LOC613037TP6353478320308539 Affinity Capture-Western
LOC613037TP6311418120308539 Affinity Capture-Western
MTHFSDTP6312228920308539 Affinity Capture-Western
MTHFSDTP6311418120308539 Affinity Capture-Western
AGBL2TP6312293220308539 Affinity Capture-Western
AGBL2TP6311418120308539 Affinity Capture-Western
CDT1TP6311418120308539 Affinity Capture-Western
CDT1TP6312355520308539 Affinity Capture-Western
PIWIL1TP6311469020308539 Affinity Capture-Western
PIWIL1TP6311418120308539 Affinity Capture-Western
DDX23TP6311481120308539 Affinity Capture-Western
DDX23TP6311418120308539 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1330810
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030819-1'