AutismKB 2.0

Annotation Details for AKR1C3


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Basic Information Top
Gene Symbol:AKR1C3 ( DD3,DDX,HA1753,HAKRB,HAKRe,HSD17B5,KIAA0119,PGFS,hluPGFS )
Gene Full Name: aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
Band: 10p15.1
Quick LinksEntrez ID:8644; OMIM: 603966; Uniprot ID:AK1C3_HUMAN; ENSEMBL ID: ENSG00000196139; HGNC ID: 386
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IDA-intracellular-
GO:0005634IDA-nucleus18574251
GO:0005737IDA-cytoplasm18574251
GO:0005829TAS-cytosol-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0001758IDA-retinal dehydrogenase activity21851338
GO:0004032IDA-alditol:NADP+ 1-oxidoreductase activity21232532
GO:0004033TAS-aldo-keto reductase (NADP) activity9792917
GO:0004745IDA-retinol dehydrogenase activity21851338
GO:0016655IDA-oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor19442656
GO:0018636IDA-phenanthrene 9,10-monooxygenase activity21851338
GO:0035410IDA-dihydrotestosterone 17-beta-dehydrogenase activity16983398
GO:0036130TAS-prostaglandin H2 endoperoxidase reductase activity-
GO:0036131TAS-prostaglandin D2 11-ketoreductase activity-
GO:0045550IDA-geranylgeranyl reductase activity21187079
GO:0045703IDA-ketoreductase activity19487289
GO:0047017IEA-prostaglandin-F synthase activity-
GO:0047020IDA-15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity22170488
GO:0047023IDA-androsterone dehydrogenase activity16983398
GO:0047035IEA-testosterone dehydrogenase (NAD+) activity-
GO:0047045IEA-testosterone 17-beta-dehydrogenase (NADP+) activity-
GO:0047086IDA-ketosteroid monooxygenase activity21232532
GO:0047115IEA-trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity-
GO:0047718IEA-indanol dehydrogenase activity-
GO:0047787IDA-delta4-3-oxosteroid 5beta-reductase activity16983398
GO:0052650TAS-NADP-retinol dehydrogenase activity-
GO ID Evidence Qualifier GO_term References
GO:0000060IDA-protein import into nucleus, translocation21787718
GO:0001523TAS-retinoid metabolic process-
GO:0006693IEP-prostaglandin metabolic process20036328
GO:0006693TAS-prostaglandin metabolic process9792917
GO:0007186IDA-G-protein coupled receptor signaling pathway18508192
GO:0007584IEP-response to nutrient19007764
GO:0008202IEP-steroid metabolic process20036328
GO:0008284IDA-positive regulation of cell proliferation18508192
GO:0008284IMP-positive regulation of cell proliferation21851338
GO:0008584IEP-male gonad development19942269
GO:0009267IEP-cellular response to starvation18641923
GO:0010942IDA-positive regulation of cell death21787718
GO:0016488IDA-farnesol catabolic process21187079
GO:0019371TAS-cyclooxygenase pathway-
GO:0030216IEP-keratinocyte differentiation22170488
GO:0034614IDA-cellular response to reactive oxygen species21787718
GO:0042448IDA-progesterone metabolic process21232532
GO:0042572IEA-retinol metabolic process-
GO:0042574IDA-retinal metabolic process21851338
GO:0044259IEP-multicellular organismal macromolecule metabolic process18641923
GO:0044597IMP-daunorubicin metabolic process20837989
GO:0044598IMP-doxorubicin metabolic process20837989
GO:0048385IDA-regulation of retinoic acid receptor signaling pathway21851338
GO:0051897IDA-positive regulation of protein kinase B signaling18508192
GO:0055114IDA-oxidation-reduction process16983398
GO:0055114TAS-oxidation-reduction process9792917
GO:0061370IMP-testosterone biosynthetic process16983398
GO:0070293NAS-renal absorption16157291
GO:0071276IDA-cellular response to cadmium ion21787718
GO:0071277IDA-cellular response to calcium ion22170488
GO:0071379IDA-cellular response to prostaglandin stimulus22170488
GO:0071384IDA-cellular response to corticosteroid stimulus19336506
GO:0071395IDA-cellular response to jasmonic acid stimulus19487289
GO:0071799IDA-cellular response to prostaglandin D stimulus18508192
GO:1900053IDA-negative regulation of retinoic acid biosynthetic process21851338
GO:2000224IMP-regulation of testosterone biosynthetic process19336506
GO:2000353IDA-positive regulation of endothelial cell apoptotic process19442656
GO:2000379IDA-positive regulation of reactive oxygen species metabolic process19442656
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2145420
  • Data Attributes: HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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