Gene Symbol:	AKR1C3 ( DD3,DDX,HA1753,HAKRB,HAKRe,HSD17B5,KIAA0119,PGFS,hluPGFS )
Gene Full Name:	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
Band:	10p15.1
Quick Links	Entrez ID:8644; OMIM: 603966; Uniprot ID:AK1C3_HUMAN; ENSEMBL ID: ENSG00000196139; HGNC ID: 386
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005622	IDA	-	intracellular	-
GO:0005634	IDA	-	nucleus	18574251
GO:0005737	IDA	-	cytoplasm	18574251
GO:0005829	TAS	-	cytosol	-
GO:0070062	IDA	-	extracellular exosome	23376485

GO ID	Evidence	Qualifier	GO_term	References
GO:0001758	IDA	-	retinal dehydrogenase activity	21851338
GO:0004032	IDA	-	alditol:NADP+ 1-oxidoreductase activity	21232532
GO:0004033	TAS	-	aldo-keto reductase (NADP) activity	9792917
GO:0004745	IDA	-	retinol dehydrogenase activity	21851338
GO:0016655	IDA	-	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	19442656
GO:0018636	IDA	-	phenanthrene 9,10-monooxygenase activity	21851338
GO:0035410	IDA	-	dihydrotestosterone 17-beta-dehydrogenase activity	16983398
GO:0036130	TAS	-	prostaglandin H2 endoperoxidase reductase activity	-
GO:0036131	TAS	-	prostaglandin D2 11-ketoreductase activity	-
GO:0045550	IDA	-	geranylgeranyl reductase activity	21187079
GO:0045703	IDA	-	ketoreductase activity	19487289
GO:0047017	IEA	-	prostaglandin-F synthase activity	-
GO:0047020	IDA	-	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	22170488
GO:0047023	IDA	-	androsterone dehydrogenase activity	16983398
GO:0047035	IEA	-	testosterone dehydrogenase (NAD+) activity	-
GO:0047045	IEA	-	testosterone 17-beta-dehydrogenase (NADP+) activity	-
GO:0047086	IDA	-	ketosteroid monooxygenase activity	21232532
GO:0047115	IEA	-	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	-
GO:0047718	IEA	-	indanol dehydrogenase activity	-
GO:0047787	IDA	-	delta4-3-oxosteroid 5beta-reductase activity	16983398
GO:0052650	TAS	-	NADP-retinol dehydrogenase activity	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000060	IDA	-	protein import into nucleus, translocation	21787718
GO:0001523	TAS	-	retinoid metabolic process	-
GO:0006693	IEP	-	prostaglandin metabolic process	20036328
GO:0006693	TAS	-	prostaglandin metabolic process	9792917
GO:0007186	IDA	-	G-protein coupled receptor signaling pathway	18508192
GO:0007584	IEP	-	response to nutrient	19007764
GO:0008202	IEP	-	steroid metabolic process	20036328
GO:0008284	IDA	-	positive regulation of cell proliferation	18508192
GO:0008284	IMP	-	positive regulation of cell proliferation	21851338
GO:0008584	IEP	-	male gonad development	19942269
GO:0009267	IEP	-	cellular response to starvation	18641923
GO:0010942	IDA	-	positive regulation of cell death	21787718
GO:0016488	IDA	-	farnesol catabolic process	21187079
GO:0019371	TAS	-	cyclooxygenase pathway	-
GO:0030216	IEP	-	keratinocyte differentiation	22170488
GO:0034614	IDA	-	cellular response to reactive oxygen species	21787718
GO:0042448	IDA	-	progesterone metabolic process	21232532
GO:0042572	IEA	-	retinol metabolic process	-
GO:0042574	IDA	-	retinal metabolic process	21851338
GO:0044259	IEP	-	multicellular organismal macromolecule metabolic process	18641923
GO:0044597	IMP	-	daunorubicin metabolic process	20837989
GO:0044598	IMP	-	doxorubicin metabolic process	20837989
GO:0048385	IDA	-	regulation of retinoic acid receptor signaling pathway	21851338
GO:0051897	IDA	-	positive regulation of protein kinase B signaling	18508192
GO:0055114	IDA	-	oxidation-reduction process	16983398
GO:0055114	TAS	-	oxidation-reduction process	9792917
GO:0061370	IMP	-	testosterone biosynthetic process	16983398
GO:0070293	NAS	-	renal absorption	16157291
GO:0071276	IDA	-	cellular response to cadmium ion	21787718
GO:0071277	IDA	-	cellular response to calcium ion	22170488
GO:0071379	IDA	-	cellular response to prostaglandin stimulus	22170488
GO:0071384	IDA	-	cellular response to corticosteroid stimulus	19336506
GO:0071395	IDA	-	cellular response to jasmonic acid stimulus	19487289
GO:0071799	IDA	-	cellular response to prostaglandin D stimulus	18508192
GO:1900053	IDA	-	negative regulation of retinoic acid biosynthetic process	21851338
GO:2000224	IMP	-	regulation of testosterone biosynthetic process	19336506
GO:2000353	IDA	-	positive regulation of endothelial cell apoptotic process	19442656
GO:2000379	IDA	-	positive regulation of reactive oxygen species metabolic process	19442656

Gene Symbol	Interactant	Interaction ID	References	Description
AKR1C3	MAGEA11	110284	16189514	Two-hybrid
AKR1C3	MAGEA11	114196	16189514	Two-hybrid
ZHX1	AKR1C3	116406	16169070	Two-hybrid
ZHX1	AKR1C3	114196	16169070	Two-hybrid
UBE2W	AKR1C3	120572	16169070	Two-hybrid
UBE2W	AKR1C3	114196	16169070	Two-hybrid
C1orf103	AKR1C3	120905	16169070	Two-hybrid
C1orf103	AKR1C3	114196	16169070	Two-hybrid

AutismKB 2.0

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