AutismKB 2.0

Annotation Details for NCOA1


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Basic Information Top
Gene Symbol:NCOA1 ( F-SRC-1,KAT13A,MGC129719,MGC129720,RIP160,SRC1,bHLHe42,bHLHe74 )
Gene Full Name: nuclear receptor coactivator 1
Band: 2p23.3
Quick LinksEntrez ID:8648; OMIM: 602691; Uniprot ID:NCOA1_HUMAN; ENSEMBL ID: ENSG00000084676; HGNC ID: 7668
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin15831516
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005886IDA-plasma membrane-
GO:0043005IEA-neuron projection-
GO:0043234IMP-protein complex15641800
GO ID Evidence Qualifier GO_term References
GO:0001012IEA-RNA polymerase II regulatory region DNA binding-
GO:0001105NAS-RNA polymerase II transcription coactivator activity15774904
GO:0003682IEA-chromatin binding-
GO:0003713IDA-transcription coactivator activity10207113
GO:0003713NAS-transcription coactivator activity15572661
GO:0004402IEA-histone acetyltransferase activity-
GO:0005515IPI-protein binding9556555
GO:0016922IPI-ligand-dependent nuclear receptor binding17363140
GO:0017162IPI-aryl hydrocarbon receptor binding15641800
GO:0019899IPI-enzyme binding12039952
GO:0030331IPI-estrogen receptor binding18563714
GO:0030374IDA-ligand-dependent nuclear receptor transcription coactivator activity15919756
GO:0032403IEA-protein complex binding-
GO:0033142IEA-progesterone receptor binding-
GO:0035257IDA-nuclear hormone receptor binding10207113
GO:0046965IEA-retinoid X receptor binding-
GO:0046983IEA-protein dimerization activity-
GO:0047485IPI-protein N-terminus binding12917342
GO:0050681NAS-androgen receptor binding15572661
GO ID Evidence Qualifier GO_term References
GO:0000435IDA-positive regulation of transcription from RNA polymerase II promoter by galactose10207113
GO:0002155IEA-regulation of thyroid hormone mediated signaling pathway-
GO:0006351IDA-transcription, DNA-templated9223431
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0007595IEA-lactation-
GO:0008584IEA-male gonad development-
GO:0015721TAS-bile acid and bile salt transport-
GO:0019216TAS-regulation of lipid metabolic process-
GO:0021549IEA-cerebellum development-
GO:0021766IEA-hippocampus development-
GO:0021854IEA-hypothalamus development-
GO:0021987IEA-cerebral cortex development-
GO:0030521NAS-androgen receptor signaling pathway15572661
GO:0030522IBA-intracellular receptor signaling pathway-
GO:0032355IEA-response to estradiol-
GO:0032526IEA-response to retinoic acid-
GO:0032570IEA-response to progesterone-
GO:0032870IBA-cellular response to hormone stimulus-
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043967IEA-histone H4 acetylation-
GO:0044849IEA-estrous cycle-
GO:0045666IEA-positive regulation of neuron differentiation-
GO:0045893IDA-positive regulation of transcription, DNA-templated11891224
GO:0045893NAS-positive regulation of transcription, DNA-templated15572661
GO:0045925IEA-positive regulation of female receptivity-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter15919756
GO:0045944NAS-positive regulation of transcription from RNA polymerase II promoter15774904
GO:0060179IEA-male mating behavior-
GO:0060713IEA-labyrinthine layer morphogenesis-
GO:1904017IEA-cellular response to Thyroglobulin triiodothyronine-
GO:2001038IEA-regulation of cellular response to drug-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NCOA1AR10686210567563 12163482 15256534 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1AR11420010567563 12163482 15256534 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1CCND11070679832502 Affinity Capture-Western; Reconstituted Complex
NCOA1CCND11142009832502 Affinity Capture-Western; Reconstituted Complex
NCOA1BCL310707410497212 Two-hybrid
NCOA1BCL311420010497212 Two-hybrid
NCOA1CREBBP1142009192892 11113179 11971985 14722092 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1CREBBP1077779192892 11113179 11971985 14722092 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1DDX510802111250900 Phenotypic Enhancement; Reconstituted Complex
NCOA1DDX511420011250900 Phenotypic Enhancement; Reconstituted Complex
NCOA1EP30011420014722092 Affinity Capture-Western
NCOA1EP30010834714722092 Affinity Capture-Western
NCOA1NR2F610837510713182 Reconstituted Complex
NCOA1NR2F611420010713182 Reconstituted Complex
NCOA1ESR11084039192892 9192902 9259327 9427757 9773983 10598586 10760302 11003650 11113179 11250900 11358671 11867769 12574227 12714702 14715875 Affinity Capture-Western; FRET; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
NCOA1ESR11142009192892 9192902 9259327 9427757 9773983 10598586 10760302 11003650 11113179 11250900 11358671 11867769 12574227 12714702 14715875 Affinity Capture-Western; FRET; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
NCOA1ESR211420010809226 11500849 14715875 Affinity Capture-Western; FRET; Two-hybrid
NCOA1ESR210840410809226 11500849 14715875 Affinity Capture-Western; FRET; Two-hybrid
NCOA1ESRRG11420011864604 Reconstituted Complex
NCOA1ESRRG10840711864604 Reconstituted Complex
NCOA1FOS1086369642216 10847592 18511550 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1FOS1142009642216 10847592 18511550 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1NR5A11087929328345 Two-hybrid
NCOA1NR5A11142009328345 Two-hybrid
NCOA1NR3C11091659590696 10659697 11266503 12118039 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1NR3C11142009590696 10659697 11266503 12118039 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1GTF2B1092148754792 Reconstituted Complex
NCOA1GTF2B1142008754792 Reconstituted Complex
NCOA1HIF1A10933810594042 Reconstituted Complex
NCOA1HIF1A11420010594042 Reconstituted Complex
NCOA1NR4A110940712082103 Reconstituted Complex
NCOA1NR4A111420012082103 Reconstituted Complex
NCOA1FOXA210941211069927 Two-hybrid
NCOA1FOXA211420011069927 Two-hybrid
NCOA1HNF4A1094149812974 Two-hybrid
NCOA1HNF4A1142009812974 Two-hybrid
NCOA1PRMT110951211050077 Reconstituted Complex
NCOA1PRMT111420011050077 Reconstituted Complex
NCOA1JUN1099289642216 10567404 10847592 Reconstituted Complex; Two-hybrid
NCOA1JUN1142009642216 10567404 10847592 Reconstituted Complex; Two-hybrid
NCOA1CIITA11041612933903 Affinity Capture-Western; Reconstituted Complex
NCOA1CIITA11420012933903 Affinity Capture-Western; Reconstituted Complex
NCOA1NFKB11108579556555 10847592 Reconstituted Complex
NCOA1NFKB11142009556555 10847592 Reconstituted Complex
NCOA1PGR11126012529333 Two-hybrid
NCOA1PGR11420012529333 Two-hybrid
NCOA1PPARA1142009407140 9626662 Reconstituted Complex; Two-hybrid
NCOA1PPARA1114619407140 9626662 Reconstituted Complex; Two-hybrid
NCOA1PPARG11146411027271 11500849 FRET; Reconstituted Complex
NCOA1PPARG11420011027271 11500849 FRET; Reconstituted Complex
NCOA1RARA1142009192892 10082574 10760302 17475621 Affinity Capture-Western; FRET; Reconstituted Complex
NCOA1RARA1118499192892 10082574 10760302 17475621 Affinity Capture-Western; FRET; Reconstituted Complex
NCOA1RARB1142008754792 Reconstituted Complex
NCOA1RARB1118508754792 Reconstituted Complex
NCOA1RXRA1142009171239 10082574 10935544 11027271 Far Western; Reconstituted Complex; Two-hybrid
NCOA1RXRA1121689171239 10082574 10935544 11027271 Far Western; Reconstituted Complex; Two-hybrid
NCOA1SMARCA411420011003650 Phenotypic Enhancement
NCOA1SMARCA411248111003650 Phenotypic Enhancement
NCOA1SMARCE111420012145209 16538531 Reconstituted Complex
NCOA1SMARCE111248912145209 16538531 Reconstituted Complex
NCOA1TRIM2111420011971985 Affinity Capture-MS
NCOA1TRIM2111261511971985 Affinity Capture-MS
NCOA1STAT311420011773079 17471507 Affinity Capture-Western; Reconstituted Complex
NCOA1STAT311265111773079 17471507 Affinity Capture-Western; Reconstituted Complex
NCOA1STAT5A11420012954634 Affinity Capture-Western
NCOA1STAT5A11265312954634 Affinity Capture-Western
NCOA1STAT611265511574547 12138096 14757047 14993689 15695802 18267973 Affinity Capture-Western; Co-crystal Structure; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
NCOA1STAT611420011574547 12138096 14757047 14993689 15695802 18267973 Affinity Capture-Western; Co-crystal Structure; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
NCOA1TBP1142008754792 Reconstituted Complex
NCOA1TBP1127718754792 Reconstituted Complex
NCOA1TEAD111420010934189 Reconstituted Complex
NCOA1TEAD111286210934189 Reconstituted Complex
NCOA1THRA1142009804773 9849963 10379889 11117530 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1THRA1129239804773 9849963 10379889 11117530 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1THRB1142009171239 9751500 Phenotypic Enhancement; Protein-peptide; Reconstituted Complex
NCOA1THRB1129249171239 9751500 Phenotypic Enhancement; Protein-peptide; Reconstituted Complex
NCOA1NKX2-111420011713256 Reconstituted Complex
NCOA1NKX2-111293611713256 Reconstituted Complex
NCOA1VDR11420010224118 11075811 11149488 17786964 Reconstituted Complex
NCOA1VDR11326410224118 11075811 11149488 17786964 Reconstituted Complex
NCOA1NCOA311420018267973 Affinity Capture-Western
NCOA1NCOA311384118267973 Affinity Capture-Western
NCOA1TEAD211404110934189 Reconstituted Complex; Two-hybrid
NCOA1TEAD211420010934189 Reconstituted Complex; Two-hybrid
KAT2BNCOA11142009296499 9445475 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KAT2BNCOA11143759296499 9445475 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA2NCOA11142009751728 11971985 18267973 Affinity Capture-MS; Affinity Capture-Western; Co-purification
NCOA2NCOA11157619751728 11971985 18267973 Affinity Capture-MS; Affinity Capture-Western; Co-purification
TRIP4NCOA111473510454579 Reconstituted Complex; Two-hybrid
TRIP4NCOA111420010454579 Reconstituted Complex; Two-hybrid
PPARGC1ANCOA111420010558993 Affinity Capture-Western; Reconstituted Complex
PPARGC1ANCOA111609710558993 Affinity Capture-Western; Reconstituted Complex
NR1H4NCOA111420011136553 Two-hybrid
NR1H4NCOA111529611136553 Two-hybrid
DDX17NCOA111420011250900 Co-fractionation; Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
DDX17NCOA111577611250900 Co-fractionation; Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
SRA1NCOA111420011250900 Phenotypic Enhancement
SRA1NCOA111532911250900 Phenotypic Enhancement
YWHAQNCOA111616811266503 Reconstituted Complex
YWHAQNCOA111420011266503 Reconstituted Complex
SNW1NCOA111420011514567 Phenotypic Enhancement; Phenotypic Suppression
SNW1NCOA111659711514567 Phenotypic Enhancement; Phenotypic Suppression
NCOR1NCOA111420012569182 Reconstituted Complex
NCOR1NCOA111497312569182 Reconstituted Complex
NR1I2NCOA111420012909012 Co-crystal Structure
NR1I2NCOA111438012909012 Co-crystal Structure
CARM1NCOA111420018511550 Reconstituted Complex
CARM1NCOA111576018511550 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
ANKRD11NCOA118348315184363 ANCO-1 interacts with SRC-1. This interaction was modeled on a demonstrated interaction between human ANCO-1 and SRC-1 from an unspecified species.
NR1I3NCOA121538815572376 CAR interacts with an unspecified isoform of SRC-1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1276523
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041001-175'