AutismKB 2.0

Annotation Details for MAPKSP1


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Basic Information Top
Gene Symbol:MAPKSP1 ( MAP2K1IP1,MAPBP,MP1 )
Gene Full Name: MAPK scaffold protein 1
Band: 4q23
Quick LinksEntrez ID:8649; OMIM: 603296; Uniprot ID:MPKS1_HUMAN; ENSEMBL ID: ENSG00000109270; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005765TAS-lysosomal membrane-
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0010008TAS-endosome membrane-
GO:0035579TAS-specific granule membrane-
GO:0070062IDA-extracellular exosome19056867
GO:0070821TAS-tertiary granule membrane-
GO:0071986IDA-Ragulator complex20381137
GO ID Evidence Qualifier GO_term References
GO:0005085IDAcontributes_toguanyl-nucleotide exchange factor activity22980980
GO:0005515IPI-protein binding20381137
GO:0019209IEA-kinase activator activity-
GO:0032947IDAcontributes_toprotein complex scaffold22980980
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000186IEA-activation of MAPKK activity-
GO:0007050TAS-cell cycle arrest-
GO:0016241TAS-regulation of macroautophagy-
GO:0032008IMP-positive regulation of TOR signaling20381137
GO:0034613IMP-cellular protein localization20381137
GO:0043312TAS-neutrophil degranulation-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0071230IMP-cellular response to amino acid stimulus20381137
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAPKSP1CDKN2A11420120655927 Co-crystal Structure
MAPKSP1CDKN2A10746320655927 Co-crystal Structure
MAPKSP1MAPK111158011266467 Reconstituted Complex
MAPKSP1MAPK111420111266467 Reconstituted Complex
MAPKSP1MAPK31142019733512 Affinity Capture-Western
MAPKSP1MAPK31115819733512 Affinity Capture-Western
MAPKSP1MAP2K11142019733512 11266467 Affinity Capture-Western; Two-hybrid
MAPKSP1MAP2K11115909733512 11266467 Affinity Capture-Western; Two-hybrid
ROBLD3MAPKSP111420111266467 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ROBLD3MAPKSP111878311266467 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050522-345'