AutismKB 2.0

Annotation Details for NUMB


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Basic Information Top
Gene Symbol:NUMB ( S171 )
Gene Full Name: numb homolog (Drosophila)
Band: 14q24.3
Quick LinksEntrez ID:8650; OMIM: 603728; Uniprot ID:NUMB_HUMAN; ENSEMBL ID: ENSG00000133961; HGNC ID: 8060
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005769IEA-early endosome-
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0016323IEA-basolateral plasma membrane-
GO:0019897IEA-extrinsic component of plasma membrane-
GO:0030136IDA-clathrin-coated vesicle19581412
GO:0045177IEA-apical part of cell-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding23211419
GO:0008013IEA-beta-catenin binding-
GO:0045294IEA-alpha-catenin binding-
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0007409IEA-axonogenesis-
GO:0021670ISS-lateral ventricle development-
GO:0021849ISS-neuroblast division in subventricular zone-
GO:0030335IGI-positive regulation of cell migration19581412
GO:0030335IMP-positive regulation of cell migration19581412
GO:0030862IEA-positive regulation of polarized epithelial cell differentiation-
GO:0034332IEA-adherens junction organization-
GO:0045746IEA-negative regulation of Notch signaling pathway-
GO:0050769ISS-positive regulation of neurogenesis-
GO:0060487IEA-lung epithelial cell differentiation-
GO:1903077IMP-negative regulation of protein localization to plasma membrane19581412
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NUMBAP2A110666912942088 Affinity Capture-Western; Reconstituted Complex
NUMBAP2A111420212942088 Affinity Capture-Western; Reconstituted Complex
NUMBDPYSL211420212942088 Affinity Capture-Western; Reconstituted Complex
NUMBDPYSL210814212942088 Affinity Capture-Western; Reconstituted Complex
NUMBL1CAM11420212942088 Affinity Capture-Western
NUMBL1CAM11009412942088 Affinity Capture-Western
NUMBMDM211420212646252 18172499 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
NUMBMDM211035812646252 18172499 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
NUMBNOTCH11109138755477 Reconstituted Complex
NUMBNOTCH11142028755477 Reconstituted Complex
NUMBSIAH111237211752454 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NUMBSIAH111420211752454 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NUMBTP5311420218172499 Affinity Capture-Western
NUMBTP5311301018172499 Affinity Capture-Western
LNX1NUMB11420211782429 14990566 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
LNX1NUMB12421911782429 14990566 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
ITCHNUMB11420212682059 18628966 Affinity Capture-Western; Reconstituted Complex
ITCHNUMB12374712682059 18628966 Affinity Capture-Western; Reconstituted Complex
RALBP1NUMB11420212775724 Affinity Capture-Western
RALBP1NUMB11613112775724 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
NUMBrs10141031, rs1047849, rs177378, rs177380, rs2108552, rs2293797, rs4899468, rs6574115 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:107423
  • Data Attributes: MGI curated and HomoloGene calculated
No data