AutismKB 2.0

Annotation Details for SOCS1


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Basic Information Top
Gene Symbol:SOCS1 ( CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP3 )
Gene Full Name: suppressor of cytokine signaling 1
Band: 16p13.13
Quick LinksEntrez ID:8651; OMIM: 603597; Uniprot ID:SOCS1_HUMAN; ENSEMBL ID: ENSG00000185338; HGNC ID: 19383
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000932IDA-P-body-
GO:0005654IDA-nucleoplasm-
GO:0005737TAS-cytoplasm9202126
GO:0005829TAS-cytosol-
GO:0031410IEA-cytoplasmic vesicle-
GO ID Evidence Qualifier GO_term References
GO:0004860TAS-protein kinase inhibitor activity9202125
GO:0005159IPI-insulin-like growth factor receptor binding9727029
GO:0005515IPI-protein binding16273093
GO:0019210ISS-kinase inhibitor activity-
GO:0019901IPI-protein kinase binding9727029
GO ID Evidence Qualifier GO_term References
GO:0001932ISS-regulation of protein phosphorylation-
GO:0006469IEA-negative regulation of protein kinase activity-
GO:0007259IEA-JAK-STAT cascade-
GO:0010533IEA-regulation of activation of Janus kinase activity-
GO:0016567IEA-protein ubiquitination-
GO:0019221IBA-cytokine-mediated signaling pathway-
GO:0019221ISS-cytokine-mediated signaling pathway-
GO:0040008IEA-regulation of growth-
GO:0042532IMP-negative regulation of tyrosine phosphorylation of STAT protein25019494
GO:0042532ISS-negative regulation of tyrosine phosphorylation of STAT protein-
GO:0045444IEA-fat cell differentiation-
GO:0045591IMP-positive regulation of regulatory T cell differentiation22387553
GO:0046426IMP-negative regulation of JAK-STAT cascade25019494
GO:0046426ISS-negative regulation of JAK-STAT cascade-
GO:0046426NAS-negative regulation of JAK-STAT cascade9727029
GO:0046627IBA-negative regulation of insulin receptor signaling pathway-
GO:0046627ISS-negative regulation of insulin receptor signaling pathway-
GO:0050707IEA-regulation of cytokine secretion-
GO:0060334TAS-regulation of interferon-gamma-mediated signaling pathway-
GO:0071230IEA-cellular response to amino acid stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SOCS1ALK10673914968112 Affinity Capture-MS
SOCS1ALK11420314968112 Affinity Capture-MS
SOCS1CRK11420310022833 Reconstituted Complex
SOCS1CRK10778810022833 Reconstituted Complex
SOCS1CSF1R10782311297560 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SOCS1CSF1R11420311297560 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SOCS1EGFR10827612070153 Affinity Capture-Western
SOCS1EGFR11420312070153 Affinity Capture-Western
SOCS1FLT311420310022833 Affinity Capture-Western
SOCS1FLT310861010022833 Affinity Capture-Western
SOCS1FYN11420310022833 Reconstituted Complex
SOCS1FYN10881010022833 Reconstituted Complex
SOCS1GHR11420310585430 Affinity Capture-Western; Reconstituted Complex
SOCS1GHR10895710585430 Affinity Capture-Western; Reconstituted Complex
SOCS1GRB210914210022833 Reconstituted Complex
SOCS1GRB211420310022833 Reconstituted Complex
SOCS1IGF1R1142039727029 Two-hybrid
SOCS1IGF1R1097019727029 Two-hybrid
SOCS1IL2RB11420311133764 Affinity Capture-Western
SOCS1IL2RB10977511133764 Affinity Capture-Western
SOCS1IRS111420312228220 Affinity Capture-Western
SOCS1IRS110987412228220 Affinity Capture-Western
SOCS1ITK11420310022833 Reconstituted Complex
SOCS1ITK10990710022833 Reconstituted Complex
SOCS1JAK21142039202126 9344848 10064597 10455112 11713228 11971965 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SOCS1JAK21099209202126 9344848 10064597 10455112 11713228 11971965 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SOCS1KIT11420310022833 Affinity Capture-Western; Two-hybrid
SOCS1KIT11001510022833 Affinity Capture-Western; Two-hybrid
SOCS1MAP3K511420316407264 Affinity Capture-Western; Reconstituted Complex
SOCS1MAP3K511038116407264 Affinity Capture-Western; Reconstituted Complex
SOCS1MPL11420310517496 Affinity Capture-Western
SOCS1MPL11049210517496 Affinity Capture-Western
SOCS1NCK111077010022833 Reconstituted Complex
SOCS1NCK111420310022833 Reconstituted Complex
SOCS1RELA11420317183367 Reconstituted Complex
SOCS1RELA11190217183367 Reconstituted Complex
SOCS1TCEB111420310051596 Affinity Capture-Western
SOCS1TCEB111278310051596 Affinity Capture-Western
SOCS1TCEB311420310051596 Affinity Capture-Western
SOCS1TCEB311278610051596 Affinity Capture-Western
SOCS1TEC1142039341160 Reconstituted Complex; Two-hybrid
SOCS1TEC1128659341160 Reconstituted Complex; Two-hybrid
SOCS1UBC11420317898043 Affinity Capture-Western
SOCS1UBC11316417898043 Affinity Capture-Western
SOCS1VAV111420310022833 Affinity Capture-Western
SOCS1VAV111325210022833 Affinity Capture-Western
SOCS1VAV211420310022833 Affinity Capture-Western
SOCS1VAV211325310022833 Affinity Capture-Western
IRS2SOCS111420312228220 Affinity Capture-Western
IRS2SOCS111420912228220 Affinity Capture-Western
COMMD1SOCS111420317183367 Affinity Capture-Western; Reconstituted Complex
COMMD1SOCS112731717183367 Affinity Capture-Western; Reconstituted Complex
SOCS2SOCS111420317898043 Affinity Capture-Western
SOCS2SOCS111436217898043 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1354910
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040801-205'