AutismKB 2.0

Annotation Details for TNKS


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Basic Information Top
Gene Symbol:TNKS ( PARP-5a,PARP5A,PARPL,TIN1,TINF1,TNKS1,pART5 )
Gene Full Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Band: 8p23.1
Quick LinksEntrez ID:8658; OMIM: 603303; Uniprot ID:TNKS1_HUMAN; ENSEMBL ID: ENSG00000173273; HGNC ID: 11941
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0000242TAS-pericentriolar material11454873
GO:0000775IEA-chromosome, centromeric region-
GO:0000781IDA-chromosome, telomeric region9822378
GO:0000784IDA-nuclear chromosome, telomeric region9822378
GO:0005643TAS-nuclear pore11454873
GO:0005654IDA-nucleoplasm-
GO:0005794IDA-Golgi apparatus22864114
GO:0005829TAS-cytosol-
GO:0016604IDA-nuclear body-
GO:0031965IDA-nuclear membrane-
GO:0031965TAS-nuclear membrane11454873
GO:0097431IDA-mitotic spindle pole16076287
GO ID Evidence Qualifier GO_term References
GO:0003950IDA-NAD+ ADP-ribosyltransferase activity9822378
GO:0003950TAS-NAD+ ADP-ribosyltransferase activity-
GO:0005515IPI-protein binding9822378
GO:0008270IDA-zinc ion binding18436240
GO:0042393IPI-histone binding26373281
GO ID Evidence Qualifier GO_term References
GO:0000209IDA-protein polyubiquitination19759537
GO:0006471IDA-protein ADP-ribosylation9822378
GO:0007052TAS-mitotic spindle organization17026964
GO:0015031IEA-protein transport-
GO:0016055TAS-Wnt signaling pathway-
GO:0016579TAS-protein deubiquitination-
GO:0018105IDA-peptidyl-serine phosphorylation17026964
GO:0018107IDA-peptidyl-threonine phosphorylation17026964
GO:0032210IC-regulation of telomere maintenance via telomerase9822378
GO:0032212IDA-positive regulation of telomere maintenance via telomerase12782650
GO:0032212IMP-positive regulation of telomere maintenance via telomerase11739745
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter19245366
GO:0051028IEA-mRNA transport-
GO:0051225TAS-spindle assembly17026964
GO:0051301IEA-cell division-
GO:0051973IDA-positive regulation of telomerase activity12782650
GO:0070198IMP-protein localization to chromosome, telomeric region15133513
GO:0070212IDA-protein poly-ADP-ribosylation9822378
GO:0070212IMP-protein poly-ADP-ribosylation25939383
GO:0070213IDA-protein auto-ADP-ribosylation9822378
GO:0090263IMP-positive regulation of canonical Wnt signaling pathway19759537
GO:0090263TAS-positive regulation of canonical Wnt signaling pathway-
GO:1904355IDA-positive regulation of telomere capping21531765
GO:1904355IMP-positive regulation of telomere capping25939383
GO:1904357IMP-negative regulation of telomere maintenance via telomere lengthening25939383
GO:1904743IDA-negative regulation of telomeric DNA binding9822378
GO:1904743IMP-negative regulation of telomeric DNA binding25939383
GO:1904908IMP-negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric26373281
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TNKSFANCD211420721314979 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TNKSFANCD210847421314979 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TNKSLNPEP11420711802774 Reconstituted Complex
TNKSLNPEP11019611802774 Reconstituted Complex
TNKSMCL111420712475993 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TNKSMCL111033812475993 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TNKSNUMA111420712080061 Reconstituted Complex
TNKSNUMA111098012080061 Reconstituted Complex
TNKSTERF11142079822378 11739745 11802774 11854288 12080061 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
TNKSTERF11128729822378 11739745 11802774 11854288 12080061 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
TNKSTNKS1142079822378 Biochemical Activity
TNKS1BP1TNKS11420711854288 12080061 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TNKS1BP1TNKS12454011854288 12080061 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
POT1TNKS11420712768206 Affinity Capture-Western
POT1TNKS11741712768206 Affinity Capture-Western
FNBP1TNKS11668614596906 Affinity Capture-Western; Two-hybrid
FNBP1TNKS11420714596906 Affinity Capture-Western; Two-hybrid
C19orf62TNKS11885519615732 Affinity Capture-MS
C19orf62TNKS11420719615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1341087
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-7450'