AutismKB 2.0

Annotation Details for EIF3A


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Basic Information Top
Gene Symbol:EIF3A ( EIF3,EIF3S10,KIAA0139,P167,TIF32,eIF3-p170,eIF3-theta,p180,p185 )
Gene Full Name: eukaryotic translation initiation factor 3, subunit A
Band: 10q26.11
Quick LinksEntrez ID:8661; OMIM: 602039; Uniprot ID:EIF3A_HUMAN; ENSEMBL ID: ENSG00000107581; HGNC ID: 3271
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus-
GO:0005730IDA-nucleolus-
GO:0005737NAS-cytoplasm9150439
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005852IDA-eukaryotic translation initiation factor 3 complex17322308
GO:0005874IEA-microtubule-
GO:0016020IDA-membrane19946888
GO:0043614IBA-multi-eIF complex-
GO:0071540IBA-eukaryotic translation initiation factor 3 complex, eIF3e-
GO:0071541IBA-eukaryotic translation initiation factor 3 complex, eIF3m-
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0003729IBA-mRNA binding-
GO:0003743ICcontributes_totranslation initiation factor activity17322308
GO:0003743IDAcontributes_totranslation initiation factor activity17581632
GO:0005198NAS-structural molecule activity9150439
GO:0005515IPI-protein binding11169732
GO:0030971IEA-receptor tyrosine kinase binding-
GO ID Evidence Qualifier GO_term References
GO:0001732IDA-formation of cytoplasmic translation initiation complex17581632
GO:0002188IBA-translation reinitiation-
GO:0006413IC-translational initiation17322308
GO:0006413TAS-translational initiation-
GO:0070373IEA-negative regulation of ERK1 and ERK2 cascade-
GO:0075522IDA-IRES-dependent viral translational initiation9573242
GO:0075525IDA-viral translational termination-reinitiation21347434
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EIF3AEIF4A111421017353931 Affinity Capture-MS
EIF3AEIF4A110828917353931 Affinity Capture-MS
EIF3AEIF4A211421017353931 Affinity Capture-MS
EIF3AEIF4A210829017353931 Affinity Capture-MS
EIF3AEIF4B1142108816444 Affinity Capture-Western; Far Western
EIF3AEIF4B1082918816444 Affinity Capture-Western; Far Western
EIF3AEIF4G111421016541103 Affinity Capture-Western
EIF3AEIF4G110829616541103 Affinity Capture-Western
EIF3AEIF4G21082979418880 10611228 Affinity Capture-Western
EIF3AEIF4G21142109418880 10611228 Affinity Capture-Western
EIF3AEIF3E11421011590142 14519125 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-purification
EIF3AEIF3E10985711590142 14519125 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-purification
EIF3AMCC11421017353931 Affinity Capture-MS
EIF3AMCC11033317353931 Affinity Capture-MS
EIF3APIK3C2A11421020562859 Affinity Capture-MS
EIF3APIK3C2A11130420562859 Affinity Capture-MS
EIF3ATFE311421017353931 Affinity Capture-MS
EIF3ATFE311288817353931 Affinity Capture-MS
EIF3AUBC11421018354498 Affinity Capture-Western
EIF3AUBC11316418354498 Affinity Capture-Western
EIF3AYWHAZ11336620936779 Two-hybrid
EIF3AYWHAZ11421020936779 Two-hybrid
EIF3IEIF3A1142108995409 14519125 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-purification
EIF3IEIF3A1142178995409 14519125 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-purification
EIF3BEIF3A1142118995410 9822659 14519125 16541103 Affinity Capture-Western; Co-purification; Far Western
EIF3BEIF3A1142108995410 9822659 14519125 16541103 Affinity Capture-Western; Co-purification; Far Western
EIF3DEIF3A1142139822659 14519125 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-purification
EIF3DEIF3A1142109822659 14519125 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-purification
EIF3FEIF3A1142109822659 14519125 17353931 19615732 Affinity Capture-MS; Affinity Capture-Western; Co-purification
EIF3FEIF3A1142149822659 14519125 17353931 19615732 Affinity Capture-MS; Affinity Capture-Western; Co-purification
EIF3HEIF3A1142109822659 14519125 17353931 19615732 Affinity Capture-MS; Affinity Capture-Western; Co-purification
EIF3HEIF3A1142169822659 14519125 17353931 19615732 Affinity Capture-MS; Affinity Capture-Western; Co-purification
EIF3CEIF3A1142129822659 14519125 Affinity Capture-Western; Co-purification
EIF3CEIF3A1142109822659 14519125 Affinity Capture-Western; Co-purification
EIF3JEIF3A1142109822659 14519125 Affinity Capture-Western; Co-purification
EIF3JEIF3A1142189822659 14519125 Affinity Capture-Western; Co-purification
EIF3GEIF3A1142109822659 14519125 Affinity Capture-Western; Co-purification; Far Western
EIF3GEIF3A1142159822659 14519125 Affinity Capture-Western; Co-purification; Far Western
EIF3LEIF3A11421011590142 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
EIF3LEIF3A11951611590142 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
DISC1EIF3A11421012812986 Affinity Capture-Western; Two-hybrid
DISC1EIF3A11806112812986 Affinity Capture-Western; Two-hybrid
EIF3KEIF3A11421014519125 17353931 Affinity Capture-MS; Co-purification
EIF3KEIF3A11814814519125 17353931 Affinity Capture-MS; Co-purification
EIF1BEIF3A11557817353931 Affinity Capture-MS
EIF1BEIF3A11421017353931 Affinity Capture-MS
EIF3MEIF3A11574317353931 Affinity Capture-MS
EIF3MEIF3A11421017353931 Affinity Capture-MS
FBXO32EIF3A11421018354498 Affinity Capture-Western; Reconstituted Complex
FBXO32EIF3A12539518354498 Affinity Capture-Western; Reconstituted Complex
WDR48EIF3A11421019615732 Affinity Capture-MS
WDR48EIF3A12164919615732 Affinity Capture-MS
USP3EIF3A11421019615732 Affinity Capture-MS
USP3EIF3A11528519615732 Affinity Capture-MS
PRKAG2EIF3A11421020562859 Affinity Capture-MS
PRKAG2EIF3A11953120562859 Affinity Capture-MS
UBA5EIF3A11421020562859 Affinity Capture-MS
UBA5EIF3A12296420562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95301
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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