AutismKB 2.0

Annotation Details for CBL


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Basic Information Top
Gene Symbol:CBL ( C-CBL,CBL2,RNF55 )
Gene Full Name: Cas-Br-M (murine) ecotropic retroviral transforming sequence
Band: 11q23.3
Quick LinksEntrez ID:867; OMIM: 165360; Uniprot ID:CBL_HUMAN; ENSEMBL ID: ENSG00000110395; HGNC ID: 1541
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane15465819
GO:0005886TAS-plasma membrane-
GO:0005925IEA-focal adhesion-
GO:0016600ISScolocalizes_withflotillin complex-
GO:0030424IEA-axon-
GO:0030426IEA-growth cone-
GO:0042629IEA-mast cell granule-
GO:0045121IBA-membrane raft-
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0001784IEA-phosphotyrosine residue binding-
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding2030914
GO:0004842TAS-ubiquitin-protein transferase activity15465819
GO:0004871IEA-signal transducer activity-
GO:0005154IEA-epidermal growth factor receptor binding-
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding5668240
GO:0017124IPI-SH3 domain binding9447983
GO:0030971IBA-receptor tyrosine kinase binding-
GO:0036312IEA-phosphatidylinositol 3-kinase regulatory subunit binding-
GO:0045296IDA-cadherin binding25468996
GO:0046875IPI-ephrin receptor binding18034775
GO:0061630IBA-ubiquitin protein ligase activity-
GO:0061630TAS-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0000209IEA-protein polyubiquitination-
GO:0006355IEA-regulation of transcription, DNA-templated-
GO:0006513IEA-protein monoubiquitination-
GO:0006974IEA-cellular response to DNA damage stimulus-
GO:0007166TAS-cell surface receptor signaling pathway15465819
GO:0007173TAS-epidermal growth factor receptor signaling pathway15465819
GO:0007175IBA-negative regulation of epidermal growth factor-activated receptor activity-
GO:0007179TAS-transforming growth factor beta receptor signaling pathway-
GO:0008543TAS-fibroblast growth factor receptor signaling pathway-
GO:0008584IEA-male gonad development-
GO:0010332IEA-response to gamma radiation-
GO:0014068IMP-positive regulation of phosphatidylinositol 3-kinase signaling17003487
GO:0014823IEA-response to activity-
GO:0016567TAS-protein ubiquitination15465819
GO:0033574IEA-response to testosterone-
GO:0035635TAS-entry of bacterium into host cell-
GO:0036120IEA-cellular response to platelet-derived growth factor stimulus-
GO:0042059IMP-negative regulation of epidermal growth factor receptor signaling pathway25178484
GO:0042059TAS-negative regulation of epidermal growth factor receptor signaling pathway-
GO:0042594IEA-response to starvation-
GO:0042787IMP-protein ubiquitination involved in ubiquitin-dependent protein catabolic process25178484
GO:0043066IMP-negative regulation of apoptotic process18070883
GO:0043303IEA-mast cell degranulation-
GO:0045471IEA-response to ethanol-
GO:0045742TAS-positive regulation of epidermal growth factor receptor signaling pathway-
GO:0046677IEA-response to antibiotic-
GO:0048260IMP-positive regulation of receptor-mediated endocytosis25178484
GO:0048260TAS-positive regulation of receptor-mediated endocytosis15465819
GO:0061024TAS-membrane organization-
GO:0070997IEA-neuron death-
GO:0071364IEA-cellular response to epidermal growth factor stimulus-
GO:0090650IEA-cellular response to oxygen-glucose deprivation-
GO:1901215IEA-negative regulation of neuron death-
GO:1990090IEA-cellular response to nerve growth factor stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CBLABL110654311494134 12475393 Affinity Capture-Western; Biochemical Activity; Far Western
CBLABL110731511494134 12475393 Affinity Capture-Western; Biochemical Activity; Far Western
CBLAXL10731515958209 Affinity Capture-Western
CBLAXL10703615958209 Affinity Capture-Western
CBLBCR1070838641358 Co-purification
CBLBCR1073158641358 Co-purification
CBLBTK1071607629518 Reconstituted Complex
CBLBTK1073157629518 Reconstituted Complex
PIK3R2CBL1073157629144 11133830 15107835 Affinity Capture-MS; Affinity Capture-Western
PIK3R2CBL1113147629144 11133830 15107835 Affinity Capture-MS; Affinity Capture-Western
GRB2CBL1073158083187 9108392 9174058 9178909 9367879 9461587 9872323 10086340 10204582 10570290 11823423 11964172 11997436 12839496 17971399 18273061 20936779 Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid
GRB2CBL1091428083187 9108392 9174058 9178909 9367879 9461587 9872323 10086340 10204582 10570290 11823423 11964172 11997436 12839496 17971399 18273061 20936779 Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid
PIK3CACBL1073158641358 Co-purification
PIK3CACBL1113088641358 Co-purification
PXNCBL1073158641358 Co-purification
PXNCBL1117878641358 Co-purification
TLN1CBL1129498641358 Co-purification
TLN1CBL1073158641358 Co-purification
YWHAQCBL1161688663231 11024037 Affinity Capture-Western; Reconstituted Complex
YWHAQCBL1073158663231 11024037 Affinity Capture-Western; Reconstituted Complex
TYK2CBL1073158780698 Affinity Capture-Western
TYK2CBL1131488780698 Affinity Capture-Western
ZAP70CBL1133678798643 10078535 Affinity Capture-Western; Co-crystal Structure
ZAP70CBL1073158798643 10078535 Affinity Capture-Western; Co-crystal Structure
ITKCBL1073158810341 Reconstituted Complex
ITKCBL1099078810341 Reconstituted Complex
CRKLCBL1073159092574 9162067 9344843 9461587 9590251 9820532 10204582 10907644 11133830 12244174 15107835 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CRKLCBL1077899092574 9162067 9344843 9461587 9590251 9820532 10204582 10907644 11133830 12244174 15107835 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CRKCBL1073159178909 9461587 Affinity Capture-Western
CRKCBL1077889178909 9461587 Affinity Capture-Western
VAV1CBL1132529200440 11331248 Affinity Capture-Western; Far Western; Reconstituted Complex
VAV1CBL1073159200440 11331248 Affinity Capture-Western; Far Western; Reconstituted Complex
LTKCBL1073159223670 Biochemical Activity
LTKCBL1102369223670 Biochemical Activity
PDGFRACBL1073159234717 Affinity Capture-Western; Reconstituted Complex
PDGFRACBL1111829234717 Affinity Capture-Western; Reconstituted Complex
YWHABCBL1073159367879 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABCBL1133619367879 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KRT18CBL1073159367879 Two-hybrid
KRT18CBL1100739367879 Two-hybrid
MYO1CCBL1073159367879 Two-hybrid
YWHAZCBL1133669367879 Two-hybrid
YWHAZCBL1073159367879 Two-hybrid
PIK3R1CBL1073159461587 9918857 11994282 15107835 18374639 Affinity Capture-MS; Affinity Capture-Western
PIK3R1CBL1113139461587 9918857 11994282 15107835 18374639 Affinity Capture-MS; Affinity Capture-Western
SHC1CBL1073159461587 10570290 Affinity Capture-Western
SHC1CBL1123619461587 10570290 Affinity Capture-Western
FYNCBL1073159535867 12244174 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FYNCBL1088109535867 12244174 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CD5CBL1073599603468 Affinity Capture-Western
CD5CBL1073159603468 Affinity Capture-Western
PLCG1CBL1073159712732 12061819 17372230 Affinity Capture-Western; Far Western; Reconstituted Complex
PLCG1CBL1113519712732 12061819 17372230 Affinity Capture-Western; Far Western; Reconstituted Complex
SH3BP2CBL1073159846481 Reconstituted Complex
SH3BP2CBL1123509846481 Reconstituted Complex
SYKCBL1073159857068 11331248 11742985 12435267 15577829 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SYKCBL1127179857068 11331248 11742985 12435267 15577829 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
EGFRCBL10731510086340 12061819 12593795 12604776 12734385 14505571 15107835 15159412 15282549 15668240 16105874 16246327 16969069 17486068 17545148 17971399 17995934 18273061 18316398 18508924 Affinity Capture-Western; Co-crystal Structure
EGFRCBL10827610086340 12061819 12593795 12604776 12734385 14505571 15107835 15159412 15282549 15668240 16105874 16246327 16969069 17486068 17545148 17971399 17995934 18273061 18316398 18508924 Affinity Capture-Western; Co-crystal Structure
HCKCBL10731510092522 11896602 Affinity Capture-Western; Biochemical Activity; Far Western; Reconstituted Complex
HCKCBL10930510092522 11896602 Affinity Capture-Western; Biochemical Activity; Far Western; Reconstituted Complex
LCP2CBL10731510204582 10477741 Affinity Capture-Western
LCP2CBL11012910204582 10477741 Affinity Capture-Western
NCK1CBL11077010204582 11494134 Affinity Capture-Western
NCK1CBL10731510204582 11494134 Affinity Capture-Western
SH2B2CBL11585010374881 15737992 18273061 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
SH2B2CBL10731510374881 15737992 18273061 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
SLACBL10731510449770 16327786 Affinity Capture-Western; Reconstituted Complex
SLACBL11239410449770 16327786 Affinity Capture-Western; Reconstituted Complex
UBE2D2CBL10731510514377 Reconstituted Complex
UBE2D2CBL11317010514377 Reconstituted Complex
UBE2L3CBL11318010531381 10966114 12234920 16735510 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
UBE2L3CBL10731510531381 10966114 12234920 16735510 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
FLOT1CBL11550611001060 Reconstituted Complex
FLOT1CBL10731511001060 Reconstituted Complex
SPRY2CBL11554711053437 11983899 12234920 12593795 12593796 16246327 17974561 18273061 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
SPRY2CBL10731511053437 11983899 12234920 12593795 12593796 16246327 17974561 18273061 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
CD2APCBL11714011067845 12559036 15128873 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CD2APCBL10731511067845 12559036 15128873 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SH3KBP1CBL11902911071869 11152963 11894095 11894096 12135478 12177062 15107835 15456872 16407834 Affinity Capture-MS; Affinity Capture-Western
SH3KBP1CBL10731511071869 11152963 11894095 11894096 12135478 12177062 15107835 15456872 16407834 Affinity Capture-MS; Affinity Capture-Western
CSKCBL10783211149930 Affinity Capture-Western
CSKCBL10731511149930 Affinity Capture-Western
PTK2BCBL10731511149930 15128873 Affinity Capture-Western
PTK2BCBL10848011149930 15128873 Affinity Capture-Western
NOTCH1CBL10731511777909 Affinity Capture-Western
NOTCH1CBL11091311777909 Affinity Capture-Western
CSF1RCBL10782311847211 11850825 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CSF1RCBL10731511847211 11850825 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SLA2CBL10731511891219 17353186 Affinity Capture-Western; Reconstituted Complex
SLA2CBL12392811891219 17353186 Affinity Capture-Western; Reconstituted Complex
SH3GL2CBL11235311894095 Affinity Capture-Western
SH3GL2CBL10731511894095 Affinity Capture-Western
SH3GL3CBL11235411894096 Affinity Capture-Western
SH3GL3CBL10731511894096 Affinity Capture-Western
METCBL10731511894096 15123609 16397241 18273061 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex
METCBL11039111894096 15123609 16397241 18273061 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex
UBCCBL11316411896602 15107835 15456872 17679095 18508924 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
UBCCBL10731511896602 15107835 15456872 17679095 18508924 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
LCKCBL10731511904433 Affinity Capture-Western
LCKCBL11012411904433 Affinity Capture-Western
SRCCBL11259211994282 Affinity Capture-Western
SRCCBL10731511994282 Affinity Capture-Western
FRS2CBL11603111997436 Affinity Capture-Western; Reconstituted Complex
FRS2CBL10731511997436 Affinity Capture-Western; Reconstituted Complex
PTPN6CBL10731512176909 Affinity Capture-Western
PTPN6CBL11174212176909 Affinity Capture-Western
LYNCBL10731512244174 Affinity Capture-Western
LYNCBL11024512244174 Affinity Capture-Western
FGRCBL10731512435267 Affinity Capture-Western
FGRCBL10855912435267 Affinity Capture-Western
SORBS2CBL11404712475393 15128873 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SORBS2CBL10731512475393 15128873 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SORBS1CBL10731512504111 15128873 Affinity Capture-Western
SORBS1CBL11583112504111 15128873 Affinity Capture-Western
INPPL1CBL10731512504111 15668240 Affinity Capture-Western
INPPL1CBL10984812504111 15668240 Affinity Capture-Western
MST1RCBL10731512802274 16740632 Affinity Capture-Western
MST1RCBL11059212802274 16740632 Affinity Capture-Western
ARHGEF7CBL11439312935897 14505571 16407834 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARHGEF7CBL10731512935897 14505571 16407834 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDC42CBL10731514505571 Affinity Capture-Western; Reconstituted Complex
CDC42CBL10743314505571 Affinity Capture-Western; Reconstituted Complex
EEF1A1CBL10731515107835 Affinity Capture-MS
EEF1A1CBL10823715107835 Affinity Capture-MS
GAPDHCBL10731515107835 Affinity Capture-MS
GAPDHCBL10886815107835 Affinity Capture-MS
UBASH3ACBL11974815107835 15159412 17709377 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
UBASH3ACBL10731515107835 15159412 17709377 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
UBASH3BCBL10731515159412 Affinity Capture-Western; Reconstituted Complex
UBASH3BCBL12439015159412 Affinity Capture-Western; Reconstituted Complex
LRIG1CBL10731515282549 Reconstituted Complex
LRIG1CBL11748915282549 Reconstituted Complex
KITCBL10731515315962 Affinity Capture-Western
KITCBL11001515315962 Affinity Capture-Western
ITGA5CBL10731515728256 Affinity Capture-Western
ITGA5CBL10988415728256 Affinity Capture-Western
UBE2MCBL10731516735510 Affinity Capture-Western
UBE2MCBL11450416735510 Affinity Capture-Western
ITSN1CBL10731516914641 Far Western
ITSN1CBL11235116914641 Far Western
CSF1CBL10782217353186 Affinity Capture-Western
CSF1CBL10731517353186 Affinity Capture-Western
KDRCBL10731517372230 Reconstituted Complex
KDRCBL10999217372230 Reconstituted Complex
GAPVD1CBL11756817545148 Affinity Capture-Western
GAPVD1CBL10731517545148 Affinity Capture-Western
CBLCBL10731517635922 17679095 Affinity Capture-Western; Co-crystal Structure
SPRY4CBL10731518273061 Affinity Capture-Western
SPRY4CBL12359918273061 Affinity Capture-Western
UBA1CBL11316518508924 Reconstituted Complex
UBA1CBL10731518508924 Reconstituted Complex
UBE2D1CBL10731518508924 Reconstituted Complex
UBE2D1CBL11316918508924 Reconstituted Complex
PTPN11CBL11174518519587 Affinity Capture-Western
PTPN11CBL10731518519587 Affinity Capture-Western
IGF1RCBL10731518632619 Affinity Capture-Western; Biochemical Activity
IGF1RCBL10970118632619 Affinity Capture-Western; Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88279
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041114-207'