AutismKB 2.0

Annotation Details for BECN1


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Basic Information Top
Gene Symbol:BECN1 ( ATG6,VPS30,beclin1 )
Gene Full Name: beclin 1, autophagy related
Band: 17q21.31
Quick LinksEntrez ID:8678; OMIM: 604378; Uniprot ID:BECN1_HUMAN; ENSEMBL ID: ENSG00000126581; HGNC ID: 1034
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000407IBA-pre-autophagosomal structure-
GO:0005634IEA-nucleus-
GO:0005739IMPcolocalizes_withmitochondrion23878393
GO:0005768IDA-endosome23878393
GO:0005776IEA-autophagosome-
GO:0005783IDA-endoplasmic reticulum23878393
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005802IEA-trans-Golgi network-
GO:0005829TAS-cytosol-
GO:0010008IEA-endosome membrane-
GO:0019898IDA-extrinsic component of membrane23878393
GO:0030425IEA-dendrite-
GO:0031966IEA-mitochondrial membrane-
GO:0034271IBA-phosphatidylinositol 3-kinase complex, class III, type I-
GO:0034272IBA-phosphatidylinositol 3-kinase complex, class III, type II-
GO:0035032ISS-phosphatidylinositol 3-kinase complex, class III-
GO:0043234IEA-protein complex-
GO:0045335IEA-phagocytic vesicle-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding16417406
GO:0031625IPI-ubiquitin protein ligase binding25127057
GO:0043548IPI-phosphatidylinositol 3-kinase binding23878393
GO:0051020IPI-GTPase binding25891078
GO ID Evidence Qualifier GO_term References
GO:0000045IBA-autophagosome assembly-
GO:0000045ISS-autophagosome assembly-
GO:0000422IMP-mitophagy25215947
GO:0000423IMP-macromitophagy23878393
GO:0000910IMP-cytokinesis20208530
GO:0001666IEA-response to hypoxia-
GO:0006914IDA-autophagy23629966
GO:0006914IMP-autophagy23184933
GO:0006915IEA-apoptotic process-
GO:0006968TAS-cellular defense response9765397
GO:0006995IBA-cellular response to nitrogen starvation-
GO:0007040IEA-lysosome organization-
GO:0007080IMP-mitotic metaphase plate congression23478334
GO:0007568IEA-aging-
GO:0008285IEA-negative regulation of cell proliferation-
GO:0010040IEA-response to iron(II) ion-
GO:0010288IEA-response to lead ion-
GO:0014068NAS-positive regulation of phosphatidylinositol 3-kinase signaling25215947
GO:0016236ISS-macroautophagy-
GO:0016236TAS-macroautophagy-
GO:0016579TAS-protein deubiquitination-
GO:0032258IBANOTCVT pathway-
GO:0032465IMP-regulation of cytokinesis20643123
GO:0032801IMP-receptor catabolic process20643123
GO:0033197IEA-response to vitamin E-
GO:0034198IEA-cellular response to amino acid starvation-
GO:0042149ISS-cellular response to glucose starvation-
GO:0042493IEA-response to drug-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043652IEA-engulfment of apoptotic cell-
GO:0044804IBA-nucleophagy-
GO:0045324IBA-late endosome to vacuole transport-
GO:0048666IEA-neuron development-
GO:0050435IEA-amyloid-beta metabolic process-
GO:0050790IEA-regulation of catalytic activity-
GO:0051607IEA-defense response to virus-
GO:0060548IMP-negative regulation of cell death19273585
GO:0070301IEA-cellular response to hydrogen peroxide-
GO:0071275IEA-cellular response to aluminum ion-
GO:0071280IEA-cellular response to copper ion-
GO:0071364IEA-cellular response to epidermal growth factor stimulus-
GO:0098780IMP-response to mitochondrial depolarisation23878393
GO:1902425IMP-positive regulation of attachment of mitotic spindle microtubules to kinetochore23478334
GO:1905672IEA-negative regulation of lysosome organization-
GO:2000378IEA-negative regulation of reactive oxygen species metabolic process-
GO:2000786IEA-positive regulation of autophagosome assembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BECN1BCL21142269765397 FRET; Two-hybrid
BECN1BCL21070689765397 FRET; Two-hybrid
BECN1BCL2L11142269765397 Two-hybrid
BECN1BCL2L11070709765397 Two-hybrid
BECN1GSPT110919020562859 Affinity Capture-MS
BECN1GSPT111422620562859 Affinity Capture-MS
BECN1PIK3C311422620562859 Affinity Capture-MS
BECN1PIK3C311130720562859 Affinity Capture-MS
BECN1PRKDC11157720562859 Affinity Capture-MS
BECN1PRKDC11422620562859 Affinity Capture-MS
BECN1TP53BP211301220562859 Affinity Capture-MS
BECN1TP53BP211422620562859 Affinity Capture-MS
BECN1TSC111422620562859 Affinity Capture-MS
BECN1TSC111309920562859 Affinity Capture-MS
BECN1UVRAG11422620562859 Affinity Capture-MS
BECN1UVRAG11324820562859 Affinity Capture-MS
BECN1SMC1A11422620562859 Affinity Capture-MS
BECN1SMC1A11387120562859 Affinity Capture-MS
GOPCBECN112138412372286 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GOPCBECN111422612372286 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AFG3L2BECN111422620562859 Affinity Capture-MS
AFG3L2BECN111613920562859 Affinity Capture-MS
SLC27A4BECN111422620562859 Affinity Capture-MS
SLC27A4BECN111619220562859 Affinity Capture-MS
ZWINTBECN111422620562859 Affinity Capture-MS
ZWINTBECN111630320562859 Affinity Capture-MS
ATG14BECN111422620562859 Affinity Capture-MS
ATG14BECN111653120562859 Affinity Capture-MS
NRBF2BECN111900920562859 Affinity Capture-MS
NRBF2BECN111422620562859 Affinity Capture-MS
PIK3R4BECN111422620562859 Affinity Capture-MS
PIK3R4BECN111905920562859 Affinity Capture-MS
TBC1D7BECN111422620562859 Affinity Capture-MS
TBC1D7BECN111941220562859 Affinity Capture-MS
PTOV1BECN111422620562859 Affinity Capture-MS
PTOV1BECN111979220562859 Affinity Capture-MS
AMBRA1BECN111422620562859 Affinity Capture-MS
AMBRA1BECN112076520562859 Affinity Capture-MS
C13orf18BECN111422620562859 Affinity Capture-MS
C13orf18BECN112316220562859 Affinity Capture-MS
TRABDBECN111422620562859 Affinity Capture-MS
TRABDBECN112321820562859 Affinity Capture-MS
SEH1LBECN111422620562859 Affinity Capture-MS
SEH1LBECN112362920562859 Affinity Capture-MS
SMC3BECN111457420562859 Affinity Capture-MS
SMC3BECN111422620562859 Affinity Capture-MS
DZIP3BECN111422620562859 Affinity Capture-MS
DZIP3BECN111502120562859 Affinity Capture-MS
KIAA0226BECN111422620562859 Affinity Capture-MS
KIAA0226BECN111506220562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1891828
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1666'