AutismKB 2.0

Annotation Details for ACTN1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACTN1 ( FLJ40884,FLJ54432 )
Gene Full Name: actinin, alpha 1
Band: 14q24.1
Quick LinksEntrez ID:87; OMIM: 102575; Uniprot ID:ACTN1_HUMAN; ENSEMBL ID: ENSG00000072110; HGNC ID: 163
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001725IDA-stress fiber11223950
GO:0001726IDA-ruffle11223950
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space16502470
GO:0005622IDA-intracellular21784188
GO:0005737IDA-cytoplasm16464232
GO:0005829TAS-cytosol-
GO:0005884IDAcolocalizes_withactin filament23434115
GO:0005886IEA-plasma membrane-
GO:0005903IEA-brush border-
GO:0005911IDA-cell-cell junction11223950
GO:0005916IEA-fascia adherens-
GO:0005925IDA-focal adhesion11223950
GO:0005925IMP-focal adhesion16807302
GO:0030018IEA-Z disc-
GO:0031093TAS-platelet alpha granule lumen-
GO:0031143TAS-pseudopodium1629252
GO:0042995IDA-cell projection16464232
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0003725IDA-double-stranded RNA binding21266579
GO:0005178IDA-integrin binding7983147
GO:0005178IPI-integrin binding11223950
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding10793131
GO:0017166IDA-vinculin binding11223950
GO:0017166IPI-vinculin binding15988023
GO:0030374IDA-ligand-dependent nuclear receptor transcription coactivator activity22351778
GO:0042803IDA-protein homodimerization activity11223950
GO:0044325IPI-ion channel binding17944866
GO:0051015IDA-actin filament binding11223950
GO ID Evidence Qualifier GO_term References
GO:0002576TAS-platelet degranulation-
GO:0007015IMP-actin filament organization23434115
GO:0030168IMPNOTplatelet activation24069336
GO:0030220IMP-platelet formation23434115
GO:0036344IMP-platelet morphogenesis23434115
GO:0042981NAS-regulation of apoptotic process16807302
GO:0048041IMP-focal adhesion assembly16807302
GO:0051017IEA-actin filament bundle assembly-
GO:0051271IMP-negative regulation of cellular component movement7983147
GO:0051639IMP-actin filament network formation24069336
GO:0051764IEA-actin crosslink formation-
GO:0070527IMPNOTplatelet aggregation23434115
GO:1903506IEA-regulation of nucleic acid-templated transcription-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGB1ACTN11098942116421 Reconstituted Complex
ITGB1ACTN11066022116421 Reconstituted Complex
CTNNA1ACTN11078767790378 Affinity Capture-Western
CTNNA1ACTN11066027790378 Affinity Capture-Western
CDH1ACTN11066029535896 Affinity Capture-Western
CDH1ACTN11074349535896 Affinity Capture-Western
GIPC1ACTN111597810198040 Affinity Capture-Western; Reconstituted Complex
GIPC1ACTN110660210198040 Affinity Capture-Western; Reconstituted Complex
ZYXACTN111356910224105 11423549 Reconstituted Complex; Two-hybrid
ZYXACTN110660210224105 11423549 Reconstituted Complex; Two-hybrid
PDLIM1ACTN111457210753915 11110697 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PDLIM1ACTN110660210753915 11110697 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TTNACTN111312411305911 Reconstituted Complex
TTNACTN110660211305911 Reconstituted Complex
ACTN1ACTN110660211470434 Co-crystal Structure
COL17A1ACTN110770411739652 Affinity Capture-Western; Two-hybrid
COL17A1ACTN110660211739652 Affinity Capture-Western; Two-hybrid
PKN1ACTN111157111802708 Affinity Capture-Western
PKN1ACTN110660211802708 Affinity Capture-Western
PYGBACTN111179212211109 Reconstituted Complex
PYGBACTN110660212211109 Reconstituted Complex
CDK5R1ACTN111437612223541 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDK5R1ACTN110660212223541 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDK5R2ACTN111445312223541 Reconstituted Complex; Two-hybrid
CDK5R2ACTN110660212223541 Reconstituted Complex; Two-hybrid
SSX2IPACTN112556712446711 Affinity Capture-Western; Reconstituted Complex
SSX2IPACTN110660212446711 Affinity Capture-Western; Reconstituted Complex
MYOTACTN111487812499399 Affinity Capture-Western
MYOTACTN110660212499399 Affinity Capture-Western
PHBACTN111126412628297 Affinity Capture-Western
PHBACTN110660212628297 Affinity Capture-Western
MAGEA11ACTN110660216189514 Two-hybrid
MAGEA11ACTN111028416189514 Two-hybrid
MYOZ1ACTN112184916189514 Two-hybrid
MYOZ1ACTN110660216189514 Two-hybrid
XRCC4ACTN111335216189514 Two-hybrid
XRCC4ACTN110660216189514 Two-hybrid
CEBPAACTN110660217082780 Affinity Capture-MS
CEBPAACTN110747917082780 Affinity Capture-MS
APCACTN110660220936779 Two-hybrid
APCACTN110682120936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2137706
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-081113-4'