AutismKB 2.0

Annotation Details for RIPK1


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Basic Information Top
Gene Symbol:RIPK1 ( FLJ39204,RIP,RIP1 )
Gene Full Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Band: 6p25.2
Quick LinksEntrez ID:8737; OMIM: 603453; Uniprot ID:RIPK1_HUMAN; ENSEMBL ID: ENSG00000137275; HGNC ID: 10019
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005739IDA-mitochondrion16507998
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0031264IDA-death-inducing signaling complex11101870
GO:0043235IDA-receptor complex8612133
GO:0045121IEA-membrane raft-
GO:0097342IDA-ripoptosome21737330
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity15001576
GO:0004672IMP-protein kinase activity22817896
GO:0004674IDA-protein serine/threonine kinase activity8612133
GO:0004871IBA-signal transducer activity-
GO:0005123IPI-death receptor binding7538908
GO:0005515IPI-protein binding10356400
GO:0005524IEA-ATP binding-
GO:0031625IPI-ubiquitin protein ligase binding18450452
GO:0032403IDA-protein complex binding22265414
GO:0042802IPI-identical protein binding22817896
GO:0070513IPI-death domain binding8612133
GO ID Evidence Qualifier GO_term References
GO:0001934IMP-positive regulation of protein phosphorylation17389591
GO:0006915IMP-apoptotic process21737330
GO:0006919TAS-activation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0007249TAS-I-kappaB kinase/NF-kappaB signaling-
GO:0007257TAS-activation of JUN kinase activity17979836
GO:0010803TAS-regulation of tumor necrosis factor-mediated signaling pathway-
GO:0010940IMP-positive regulation of necrotic cell death20550618
GO:0016579TAS-protein deubiquitination-
GO:0032757IDA-positive regulation of interleukin-8 production16127453
GO:0032760IDA-positive regulation of tumor necrosis factor production16127453
GO:0033209IC-tumor necrosis factor-mediated signaling pathway8612133
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0034612IMP-response to tumor necrosis factor10521396
GO:0035666TAS-TRIF-dependent toll-like receptor signaling pathway-
GO:0036289IDA-peptidyl-serine autophosphorylation23473668
GO:0043065IDA-positive regulation of apoptotic process8612133
GO:0043065IMP-positive regulation of apoptotic process22173242
GO:0043068IMP-positive regulation of programmed cell death16611992
GO:0043123IDA-positive regulation of I-kappaB kinase/NF-kappaB signaling17389591
GO:0043123IEP-positive regulation of I-kappaB kinase/NF-kappaB signaling12761501
GO:0043124IMP-negative regulation of I-kappaB kinase/NF-kappaB signaling17047155
GO:0044257IDA-cellular protein catabolic process17389591
GO:0045651IMP-positive regulation of macrophage differentiation17047155
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter16127453
GO:0046330IDA-positive regulation of JNK cascade17389591
GO:0046777IDA-protein autophosphorylation8612133
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity8612133
GO:0051260IDA-protein homooligomerization22817896
GO:0051291IMP-protein heterooligomerization22817896
GO:0060544TAS-regulation of necroptotic process-
GO:0060545IMP-positive regulation of necroptotic process22028622
GO:0070231ISS-T cell apoptotic process-
GO:0070266IMP-necroptotic process21737330
GO:0070266TAS-necroptotic process-
GO:0070926IMP-regulation of ATP:ADP antiporter activity16507998
GO:0071356IDA-cellular response to tumor necrosis factor17389591
GO:0071363IEA-cellular response to growth factor stimulus-
GO:0071550TAS-death-inducing signaling complex assembly-
GO:0097190TAS-apoptotic signaling pathway-
GO:0097191IDA-extrinsic apoptotic signaling pathway7538908
GO:0097191IMP-extrinsic apoptotic signaling pathway8612133
GO:0097296TAS-activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway-
GO:0097343IMP-ripoptosome assembly21737330
GO:0097527IMP-necroptotic signaling pathway11101870
GO:0097527ISS-necroptotic signaling pathway-
GO:1901026IBA-ripoptosome assembly involved in necroptotic process-
GO:1902041TAS-regulation of extrinsic apoptotic signaling pathway via death domain receptors-
GO:1902042TAS-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-
GO:1905206IMP-positive regulation of hydrogen peroxide-induced cell death20550618
GO:1990000IMP-amyloid fibril formation22817896
GO:2000379TAS-positive regulation of reactive oxygen species metabolic process17979836
GO:2001237IMP-negative regulation of extrinsic apoptotic signaling pathway21525013
GO:2001238IMP-positive regulation of extrinsic apoptotic signaling pathway21525013
GO:2001240IEA-negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RIPK1BIRC210682618570872 19854138 Affinity Capture-Western; Biochemical Activity
RIPK1BIRC211427418570872 19854138 Affinity Capture-Western; Biochemical Activity
RIPK1BIRC310682718570872 Affinity Capture-Western; Biochemical Activity
RIPK1BIRC311427418570872 Affinity Capture-Western; Biochemical Activity
RIPK1FAS1068517538908 Two-hybrid
RIPK1FAS1142747538908 Two-hybrid
RIPK1CA1110722418450452 Affinity Capture-Western; Biochemical Activity
RIPK1CA1111427418450452 Affinity Capture-Western; Biochemical Activity
RIPK1CASP811427411002417 18570872 19060883 Affinity Capture-Western
RIPK1CASP810729111002417 18570872 19060883 Affinity Capture-Western
RIPK1CASP1011427411002417 Affinity Capture-Western
RIPK1CASP1010729311002417 Affinity Capture-Western
RIPK1CYLD11427417981138 Affinity Capture-Western
RIPK1CYLD10792017981138 Affinity Capture-Western
RIPK1EGFR10827611116146 Affinity Capture-Western
RIPK1EGFR11427411116146 Affinity Capture-Western
RIPK1HSP90AA111427416968706 Affinity Capture-Western
RIPK1HSP90AA110955216968706 Affinity Capture-Western
RIPK1MAP3K711274816543241 18570872 Affinity Capture-Western
RIPK1MAP3K711427416543241 18570872 Affinity Capture-Western
RIPK1TNF11427412753742 Affinity Capture-Western
RIPK1TNF11297912753742 Affinity Capture-Western
RIPK1TNFAIP311298315258597 19131965 Affinity Capture-Western; Biochemical Activity
RIPK1TNFAIP311427415258597 19131965 Affinity Capture-Western; Biochemical Activity
RIPK1TNFRSF1A1142748612133 8985253 11002422 16968706 18621737 18724939 18939944 Affinity Capture-Western
RIPK1TNFRSF1A1129868612133 8985253 11002422 16968706 18621737 18724939 18939944 Affinity Capture-Western
RIPK1TRAF11142748612133 Affinity Capture-Western
RIPK1TRAF11130378612133 Affinity Capture-Western
RIPK1TRAF21142748612133 8702708 9020361 11479302 Affinity Capture-Western; Two-hybrid
RIPK1TRAF21130388612133 8702708 9020361 11479302 Affinity Capture-Western; Two-hybrid
RIPK1TRAF31142748612133 Affinity Capture-Western
RIPK1TRAF31130398612133 Affinity Capture-Western
RIPK1TRAF511427411479302 Affinity Capture-Western
RIPK1TRAF511304011479302 Affinity Capture-Western
RIPK1UBC11427412753742 15258597 16543241 16968706 18299187 18450452 18570872 18621737 18724939 Affinity Capture-Western
RIPK1UBC11316412753742 15258597 16543241 16968706 18299187 18450452 18570872 18621737 18724939 Affinity Capture-Western
RIPK1IKBKG11427410880512 16543241 Affinity Capture-Western
RIPK1IKBKG11408910880512 16543241 Affinity Capture-Western
RIPK1TRADD1142748612133 Affinity Capture-Western; Two-hybrid
RIPK1TRADD1142578612133 Affinity Capture-Western; Two-hybrid
CRADDRIPK11142748985253 9044836 Reconstituted Complex
CRADDRIPK11142758985253 9044836 Reconstituted Complex
TNFRSF10BRIPK11142749430227 Affinity Capture-Western
TNFRSF10BRIPK11143239430227 Affinity Capture-Western
RIPK3RIPK111427410339433 Affinity Capture-Western; Two-hybrid
RIPK3RIPK111622410339433 Affinity Capture-Western; Two-hybrid
SQSTM1RIPK111439710356400 Affinity Capture-Western; Reconstituted Complex
SQSTM1RIPK111427410356400 Affinity Capture-Western; Reconstituted Complex
CFLARRIPK111427410837247 11002417 Affinity Capture-Western
CFLARRIPK111436410837247 11002417 Affinity Capture-Western
MAP3K14RIPK111427411116146 Affinity Capture-Western
MAP3K14RIPK111448711116146 Affinity Capture-Western
RNF216RIPK111427411854271 16968706 Affinity Capture-Western; Two-hybrid
RNF216RIPK111998111854271 16968706 Affinity Capture-Western; Two-hybrid
FADDRIPK111427411854271 Two-hybrid
FADDRIPK111430211854271 Two-hybrid
TRPC4APRIPK111427414585990 Affinity Capture-Western
TRPC4APRIPK111756914585990 Affinity Capture-Western
TICAM1RIPK111427415064760 Affinity Capture-Western
TICAM1RIPK112711415064760 Affinity Capture-Western
LRDDRIPK111427416360037 Affinity Capture-Western
LRDDRIPK112064516360037 Affinity Capture-Western
TAB2RIPK111427418299187 Affinity Capture-Western
TAB2RIPK111674018299187 Affinity Capture-Western
RNF11RIPK111427419131965 Affinity Capture-Western
RNF11RIPK111794119131965 Affinity Capture-Western
ITCHRIPK111427419131965 Affinity Capture-Western
ITCHRIPK112374719131965 Affinity Capture-Western
TAX1BP1RIPK111427419131965 Affinity Capture-Western
TAX1BP1RIPK111440519131965 Affinity Capture-Western
USP21RIPK111427419910467 Affinity Capture-Western
USP21RIPK111795019910467 Affinity Capture-Western
CDC42BPBRIPK111427420936779 Two-hybrid
CDC42BPBRIPK111494720936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:108212
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070705-132'