AutismKB 2.0

Annotation Details for TNFSF10


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Basic Information Top
Gene Symbol:TNFSF10 ( APO2L,Apo-2L,CD253,TL2,TRAIL )
Gene Full Name: tumor necrosis factor (ligand) superfamily, member 10
Band: 3q26
Quick LinksEntrez ID:8743; OMIM: 603598; Uniprot ID:TNF10_HUMAN; ENSEMBL ID: ENSG00000121858; HGNC ID: 11925
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IEA-extracellular space-
GO:0005887TAS-integral component of plasma membrane8663110
GO:0070062IDA-extracellular exosome19199708
GO ID Evidence Qualifier GO_term References
GO:0005102TAS-receptor binding8663110
GO:0005125IEA-cytokine activity-
GO:0005164IEA-tumor necrosis factor receptor binding-
GO:0005515IPI-protein binding10549288
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006915IEA-apoptotic process-
GO:0006919TAS-activation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0006955IEA-immune response-
GO:0007165TAS-signal transduction8663110
GO:0007166TAS-cell surface receptor signaling pathway-
GO:0007267TAS-cell-cell signaling8777713
GO:0008584IEA-male gonad development-
GO:0032868IEA-response to insulin-
GO:0043065IDA-positive regulation of apoptotic process21525171
GO:0043123IEP-positive regulation of I-kappaB kinase/NF-kappaB signaling12761501
GO:0043280IDA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process21459798
GO:0090200IDA-positive regulation of release of cytochrome c from mitochondria22266862
GO:0097296TAS-activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway-
GO:1902041TAS-regulation of extrinsic apoptotic signaling pathway via death domain receptors-
GO:1902042TAS-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-
GO:2001238IDA-positive regulation of extrinsic apoptotic signaling pathway20097879
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TNFSF10ACP511428016169070 Two-hybrid
TNFSF10ACP510657016169070 Two-hybrid
TNFRSF10ATNFSF101142809082980 Affinity Capture-Western
TNFRSF10ATNFSF101143259082980 Affinity Capture-Western
TNFRSF10BTNFSF101142809311998 10549288 11094155 Affinity Capture-MS; Co-crystal Structure; Reconstituted Complex
TNFRSF10BTNFSF101143239311998 10549288 11094155 Affinity Capture-MS; Co-crystal Structure; Reconstituted Complex
TNFRSF10DTNFSF101142809430226 Reconstituted Complex
TNFRSF10DTNFSF101143219430226 Reconstituted Complex
TNFSF10TNFSF1011428010651627 Co-crystal Structure
C7orf64TNFSF1011428016169070 Two-hybrid
C7orf64TNFSF1012385516169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107414
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010801-1'