AutismKB 2.0

Annotation Details for RIPK2


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Basic Information Top
Gene Symbol:RIPK2 ( CARD3,CARDIAK,CCK,GIG30,RICK,RIP2 )
Gene Full Name: receptor-interacting serine-threonine kinase 2
Band: 8q21.3
Quick LinksEntrez ID:8767; OMIM: 603455; Uniprot ID:RIPK2_HUMAN; ENSEMBL ID: ENSG00000104312; HGNC ID: 10020
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm21887730
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005856IDA-cytoskeleton21887730
GO:0031982IDA-vesicle21887730
GO:0043234IDA-protein complex21887730
GO ID Evidence Qualifier GO_term References
GO:0004674IBA-protein serine/threonine kinase activity-
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004715IEA-non-membrane spanning protein tyrosine kinase activity-
GO:0004871TAS-signal transducer activity9642260
GO:0005102IPI-receptor binding24790089
GO:0005515IPI-protein binding19337385
GO:0005524IEA-ATP binding-
GO:0030274IPI-LIM domain binding15657077
GO:0042802IPI-identical protein binding25416956
GO:0042803IDA-protein homodimerization activity19337385
GO:0050700IDA-CARD domain binding10329646
GO:0050700IPI-CARD domain binding11087742
GO ID Evidence Qualifier GO_term References
GO:0000165IBA-MAPK cascade-
GO:0000187TAS-activation of MAPK activity-
GO:0001961IEA-positive regulation of cytokine-mediated signaling pathway-
GO:0002250IBA-adaptive immune response-
GO:0002250ISS-adaptive immune response-
GO:0006915IEA-apoptotic process-
GO:0006954TAS-inflammatory response9705938
GO:0007165TAS-signal transduction9642260
GO:0007249ISS-I-kappaB kinase/NF-kappaB signaling-
GO:0007254TAS-JNK cascade-
GO:0010800IDA-positive regulation of peptidyl-threonine phosphorylation21887730
GO:0016579TAS-protein deubiquitination-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0031398IMP-positive regulation of protein ubiquitination15620648
GO:0031398NAS-positive regulation of protein ubiquitination22412986
GO:0031663IEA-lipopolysaccharide-mediated signaling pathway-
GO:0032722IEA-positive regulation of chemokine production-
GO:0032727NAS-positive regulation of interferon-alpha production22412986
GO:0032728NAS-positive regulation of interferon-beta production22412986
GO:0032729IEA-positive regulation of interferon-gamma production-
GO:0032735NAS-positive regulation of interleukin-12 production22412986
GO:0032743IEA-positive regulation of interleukin-2 production-
GO:0032755IEA-positive regulation of interleukin-6 production-
GO:0032760IEA-positive regulation of tumor necrosis factor production-
GO:0033091IEA-positive regulation of immature T cell proliferation-
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation21887730
GO:0034134IDA-toll-like receptor 2 signaling pathway11894098
GO:0034142IEA-toll-like receptor 4 signaling pathway-
GO:0042098IEA-T cell proliferation-
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043066TAS-negative regulation of apoptotic process-
GO:0043123IDA-positive regulation of I-kappaB kinase/NF-kappaB signaling10329646
GO:0043330IEA-response to exogenous dsRNA-
GO:0045087IDA-innate immune response23806334
GO:0045087ISS-innate immune response-
GO:0045627IEA-positive regulation of T-helper 1 cell differentiation-
GO:0045944NAS-positive regulation of transcription from RNA polymerase II promoter22412986
GO:0046330IEA-positive regulation of JNK cascade-
GO:0046641IEA-positive regulation of alpha-beta T cell proliferation-
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation21887730
GO:0050830IEA-defense response to Gram-positive bacterium-
GO:0050852ISS-T cell receptor signaling pathway-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity21887730
GO:0051092TAS-positive regulation of NF-kappaB transcription factor activity-
GO:0070374IEA-positive regulation of ERK1 and ERK2 cascade-
GO:0070423TAS-nucleotide-binding oligomerization domain containing signaling pathway-
GO:0070427IEA-nucleotide-binding oligomerization domain containing 1 signaling pathway-
GO:0070431IDA-nucleotide-binding oligomerization domain containing 2 signaling pathway23806334
GO:0070555IEA-response to interleukin-1-
GO:0070671IEA-response to interleukin-12-
GO:0070673IEA-response to interleukin-18-
GO:0071223IEA-cellular response to lipoteichoic acid-
GO:0071224IEA-cellular response to peptidoglycan-
GO:0071225IDA-cellular response to muramyl dipeptide21887730
GO:1904417IEA-positive regulation of xenophagy-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RIPK2BIRC21143009642260 9705938 Affinity Capture-Western
RIPK2BIRC21068269642260 9705938 Affinity Capture-Western
RIPK2BIRC31143009705938 Affinity Capture-Western
RIPK2BIRC31068279705938 Affinity Capture-Western
RIPK2CASP11072849705938 Affinity Capture-Western
RIPK2CASP11143009705938 Affinity Capture-Western
RIPK2CD401143009642260 Affinity Capture-Western
RIPK2CD401073969642260 Affinity Capture-Western
RIPK2COP10770811432859 Affinity Capture-Western
RIPK2COP11430011432859 Affinity Capture-Western
RIPK2RPL3811430017353931 Affinity Capture-MS
RIPK2RPL3811208817353931 Affinity Capture-MS
RIPK2RPS1411212217353931 Affinity Capture-MS
RIPK2RPS1411430017353931 Affinity Capture-MS
RIPK2TNFRSF1A1129869642260 Affinity Capture-Western
RIPK2TNFRSF1A1143009642260 Affinity Capture-Western
RIPK2TRAF11130379705938 Affinity Capture-Western
RIPK2TRAF11143009705938 Affinity Capture-Western
RIPK2TRAF21130389705938 Affinity Capture-Western
RIPK2TRAF21143009705938 Affinity Capture-Western
RIPK2TRAF51130409642260 Affinity Capture-Western
RIPK2TRAF51143009642260 Affinity Capture-Western
RIPK2TRAF61130419642260 Affinity Capture-Western
RIPK2TRAF61143009642260 Affinity Capture-Western
RIPK2UBC11316418342009 Affinity Capture-Western
RIPK2UBC11430018342009 Affinity Capture-Western
RIPK2UBE2I11317716189514 Two-hybrid
RIPK2UBE2I11430016189514 Two-hybrid
RIPK2IKBKG11408910880512 Affinity Capture-Western
RIPK2IKBKG11430010880512 Affinity Capture-Western
CFLARRIPK21143649575181 Affinity Capture-Western
CFLARRIPK21143009575181 Affinity Capture-Western
NOD1RIPK211566410329646 Affinity Capture-Western
NOD1RIPK211430010329646 Affinity Capture-Western
NOD2RIPK212207711087742 Affinity Capture-Western
NOD2RIPK211430011087742 Affinity Capture-Western
CARD6RIPK212419312775719 Affinity Capture-Western
CARD6RIPK211430012775719 Affinity Capture-Western
PHB2RIPK211430017353931 Affinity Capture-MS
PHB2RIPK211645917353931 Affinity Capture-MS
KCTD12RIPK211430017353931 Affinity Capture-MS
KCTD12RIPK212541917353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1891456
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030902-3'